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Protein

Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial

Gene

GPX6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.By similarity

Catalytic activityi

2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105By similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: TAIR
  • phospholipid-hydroperoxide glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  • response to cadmium ion Source: TAIR
  • response to oxidative stress Source: InterPro
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processStress response

Enzyme and pathway databases

ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei2502 AtGPx06

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial (EC:1.11.1.12)
Short name:
AtGPX1
Short name:
PHGPx
Gene namesi
Name:GPX6
Synonyms:GPX1
Ordered Locus Names:At4g11600
ORF Names:T5C23.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G11600
TAIRilocus:2139712 AT4G11600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 54MitochondrionSequence analysisAdd BLAST54
ChainiPRO_000001308855 – 232Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrialAdd BLAST178

Proteomic databases

PaxDbiO48646
PRIDEiO48646

PTM databases

iPTMnetiO48646

Expressioni

Tissue specificityi

Expressed at a low but detectable level in leaves, stems, and flowers, but at a higher level in siliques and even higher in roots. Predominantly expressed in seeds.2 Publications

Inductioni

By salt stress, osmotic stress, cold treatment, and metals. Up-regulated by salicylic acid (SA), jasmonic acid (JA), abscisic acid (ABA) and auxin.3 Publications

Gene expression databases

ExpressionAtlasiO48646 baseline and differential
GenevisibleiO48646 AT

Interactioni

Protein-protein interaction databases

BioGridi12064, 1 interactor
IntActiO48646, 2 interactors
MINTiO48646
STRINGi3702.AT4G11600.1

Structurei

3D structure databases

ProteinModelPortaliO48646
SMRiO48646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
HOGENOMiHOG000277054
InParanoidiO48646
KOiK00432
OMAiVTFPIFH
OrthoDBiEOG09360NO2
PhylomeDBiO48646

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O48646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSSIRLLY IRRTSPLLRS LSSSSSSSSS KRFDSAKPLF NSHRIISLPI
60 70 80 90 100
STTGAKLSRS EHSMAASSEP KSLYDFTVKD AKGNDVDLSI YKGKVLLIVN
110 120 130 140 150
VASQCGLTNS NYTELAQLYE KYKGHGFEIL AFPCNQFGNQ EPGTNEEIVQ
160 170 180 190 200
FACTRFKAEY PIFDKVDVNG DKAAPVYKFL KSSKGGLFGD GIKWNFAKFL
210 220 230
VDKDGNVVDR FAPTTSPLSI EKDVKKLLGV TA
Length:232
Mass (Da):25,584
Last modified:May 10, 2004 - v2
Checksum:i93F3084A8A331494
GO

Sequence cautioni

The sequence AAC09173 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM66969 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA24226 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB39931 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB78203 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30S → SSSS (Ref. 1) Curated1
Sequence conflicti51S → Y (PubMed:9511228).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030132 mRNA Translation: AAC09173.1 Different initiation.
AL049500 Genomic DNA Translation: CAB39931.1 Different initiation.
AL161532 Genomic DNA Translation: CAB78203.1 Different initiation.
CP002687 Genomic DNA Translation: AEE83029.1
AY039863 mRNA Translation: AAK63967.1
AY077655 mRNA Translation: AAL76133.1
AY088647 mRNA Translation: AAM66969.1 Different initiation.
AB001568 mRNA Translation: BAA24226.1 Different initiation.
PIRiT04207
RefSeqiNP_192897.2, NM_117229.4
UniGeneiAt.23184

Genome annotation databases

EnsemblPlantsiAT4G11600.1; AT4G11600.1; AT4G11600
GeneIDi826765
GrameneiAT4G11600.1; AT4G11600.1; AT4G11600
KEGGiath:AT4G11600

Similar proteinsi

Entry informationi

Entry nameiGPX6_ARATH
AccessioniPrimary (citable) accession number: O48646
Secondary accession number(s): Q94BV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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