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UniProtKB - O46655 (WAP_PIG)

Entry version 119 (02 Dec 2020)
Sequence version 1 (01 Jun 1998)
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Protein

Whey acidic protein

Gene

WAP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMilk protein, Protease inhibitor

Protein family/group databases

MEROPS protease database

More...MEROPSi		I17.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Whey acidic protein
Short name:
WAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18
  • UP000008227 Componenti: Chromosome 18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004135120 – 132Whey acidic proteinAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 60PROSITE-ProRule annotation1 Publication
Disulfide bondi43 ↔ 65PROSITE-ProRule annotation1 Publication
Disulfide bondi47 ↔ 59PROSITE-ProRule annotation1 Publication
Disulfide bondi53 ↔ 69PROSITE-ProRule annotation1 Publication
Disulfide bondi83 ↔ 114PROSITE-ProRule annotation1 Publication
Disulfide bondi95 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi101 ↔ 113PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 122PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O46655

PeptideAtlas

More...PeptideAtlasi		O46655

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Milk-specific; major protein component of milk whey.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSSSCG00000016731, Expressed in female gonad and 6 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O46655, SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9823.ENSSSCP00000017721

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O46655

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 73WAP 1PROSITE-ProRule annotationAdd BLAST51
Domaini76 – 126WAP 2PROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 39Poly-Ser4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXHY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111762

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_156961_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O46655

Identification of Orthologs from Complete Genome Data

More...OMAi		PQGTKCC

Database of Orthologous Groups

More...OrthoDBi		1438317at2759

TreeFam database of animal gene trees

More...TreeFami		TF339378

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.75.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036645, Elafin-like_sf
IPR008197, WAP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00095, WAP, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00003, 4DISULPHCORE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00217, WAP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57256, SSF57256, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51390, WAP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O46655-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFLTSLALA LIALEAALAL APALNLPGLA TCPELSSSSE DPCVISCVND 
        60         70         80         90        100
ESCPQGTKCC ARSPCSRSCT VPLLVPVPKA GRCPWVPAPL APELCLEKNE 
       110        120        130 
CSRDDQCRGN KKCCFSSCAM RCLDPDTEAP LQ
Length:132
Mass (Da):13,956
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F7796493C0D98E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39 – 40Missing AA sequence (PubMed:9513079).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ000221 mRNA Translation: CAA03950.1
AF320306 Genomic DNA Translation: AAK52450.1
AF034646 mRNA Translation: AAC72878.1

NCBI Reference Sequences

More...RefSeqi		NP_999006.1, NM_213841.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSSSCT00000018212; ENSSSCP00000017721; ENSSSCG00000016731
ENSSSCT00015003203; ENSSSCP00015001061; ENSSSCG00015002600
ENSSSCT00025009917; ENSSSCP00025003957; ENSSSCG00025007450
ENSSSCT00030043698; ENSSSCP00030019754; ENSSSCG00030031546
ENSSSCT00035087512; ENSSSCP00035036539; ENSSSCG00035064989
ENSSSCT00040021168; ENSSSCP00040008877; ENSSSCG00040015722
ENSSSCT00045054069; ENSSSCP00045037630; ENSSSCG00045031688
ENSSSCT00050053853; ENSSSCP00050022665; ENSSSCG00050039885
ENSSSCT00055046999; ENSSSCP00055037489; ENSSSCG00055023873
ENSSSCT00060005564; ENSSSCP00060001890; ENSSSCG00060004478
ENSSSCT00065024780; ENSSSCP00065010118; ENSSSCG00065018652
ENSSSCT00070030198; ENSSSCP00070025188; ENSSSCG00070015373

Database of genes from NCBI RefSeq genomes

More...GeneIDi		396835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ssc:396835

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000221 mRNA Translation: CAA03950.1
AF320306 Genomic DNA Translation: AAK52450.1
AF034646 mRNA Translation: AAC72878.1
RefSeqiNP_999006.1, NM_213841.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CJHmodel-A20-132[»]
SMRiO46655
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017721

Protein family/group databases

MEROPSiI17.001

Proteomic databases

PaxDbiO46655
PeptideAtlasiO46655

Genome annotation databases

EnsembliENSSSCT00000018212; ENSSSCP00000017721; ENSSSCG00000016731
ENSSSCT00015003203; ENSSSCP00015001061; ENSSSCG00015002600
ENSSSCT00025009917; ENSSSCP00025003957; ENSSSCG00025007450
ENSSSCT00030043698; ENSSSCP00030019754; ENSSSCG00030031546
ENSSSCT00035087512; ENSSSCP00035036539; ENSSSCG00035064989
ENSSSCT00040021168; ENSSSCP00040008877; ENSSSCG00040015722
ENSSSCT00045054069; ENSSSCP00045037630; ENSSSCG00045031688
ENSSSCT00050053853; ENSSSCP00050022665; ENSSSCG00050039885
ENSSSCT00055046999; ENSSSCP00055037489; ENSSSCG00055023873
ENSSSCT00060005564; ENSSSCP00060001890; ENSSSCG00060004478
ENSSSCT00065024780; ENSSSCP00065010118; ENSSSCG00065018652
ENSSSCT00070030198; ENSSSCP00070025188; ENSSSCG00070015373
GeneIDi396835
KEGGissc:396835

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22373

Phylogenomic databases

eggNOGiENOG502RXHY, Eukaryota
GeneTreeiENSGT00730000111762
HOGENOMiCLU_156961_0_0_1
InParanoidiO46655
OMAiPQGTKCC
OrthoDBi1438317at2759
TreeFamiTF339378

Gene expression databases

BgeeiENSSSCG00000016731, Expressed in female gonad and 6 other tissues
GenevisibleiO46655, SS

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645, Elafin-like_sf
IPR008197, WAP_dom
PfamiView protein in Pfam
PF00095, WAP, 2 hits
PRINTSiPR00003, 4DISULPHCORE
SMARTiView protein in SMART
SM00217, WAP, 2 hits
SUPFAMiSSF57256, SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390, WAP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWAP_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O46655
Secondary accession number(s): O97559
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: December 2, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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