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Protein

Alcohol dehydrogenase class-2 isozyme 1

Gene

ADH2-1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 210NADBy similarity6
Nucleotide bindingi298 – 300NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-2 isozyme 1 (EC:1.1.1.1)
Gene namesi
Name:ADH2-1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606841 – 379Alcohol dehydrogenase class-2 isozyme 1Add BLAST379

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000010873

Structurei

3D structure databases

ProteinModelPortaliO46649
SMRiO46649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiO46649
KOiK13980

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028632 Zinc_ADH_II
PANTHERiPTHR43880:SF14 PTHR43880:SF14, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

O46649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTKGKVIKC KAAIAWEAGK PLSIEEVEVA PPKAHEVRVQ INAAGLCRSD
60 70 80 90 100
THVINPKFEG AFLPVILGHE GAGIVESVGP GVTNVKPGDK VIPLYIPHCK
110 120 130 140 150
KCKFCLSPLT NFCEKFCKGK NPLIEQELME DKTSRFTCKG KSIYHFFGIS
160 170 180 190 200
AFSQYTVVKD VNLAKIDDDA NLERVCLIGC GFSTGYGAAI NTAKVTPGST
210 220 230 240 250
CAVFGLGGVG LSAIMGCKTA GASRIIAIDI NSDKFAKAKA LGATDCLNPR
260 270 280 290 300
ELNKPVQDVI VEMTNGGVDF AIDCAGGSEV MKATVDCATV GWGSCTFVGV
310 320 330 340 350
NLADKGLTIS PIELILGRTL KGTNFGGWDA ETVPKLVSDY KNGKFDLDAL
360 370
VTHTLPFDKI NEALNLLDQG KSIRTVLIF
Length:379
Mass (Da):40,237
Last modified:January 23, 2007 - v2
Checksum:iC32A2466EDA932C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002388 mRNA Translation: CAA05362.1
RefSeqiNP_001164342.1, NM_001170871.1
UniGeneiOcu.7768

Genome annotation databases

GeneIDi100327260
KEGGiocu:100327260

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002388 mRNA Translation: CAA05362.1
RefSeqiNP_001164342.1, NM_001170871.1
UniGeneiOcu.7768

3D structure databases

ProteinModelPortaliO46649
SMRiO46649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000010873

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100327260
KEGGiocu:100327260

Organism-specific databases

CTDi100327260

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiO46649
KOiK13980

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028632 Zinc_ADH_II
PANTHERiPTHR43880:SF14 PTHR43880:SF14, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHP_RABIT
AccessioniPrimary (citable) accession number: O46649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: December 20, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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