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Entry version 105 (07 Oct 2020)
Sequence version 1 (01 Jun 1998)
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Protein

Major prion protein

Gene

PrP

Organism
Capra hircus (Goat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPrionUniRule annotationImportedARBA annotation
LigandCopperARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major prion proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PrPImported
Synonyms:PRNPImported, PrnpImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCapra hircus (Goat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9925 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 24HelicalSequence analysisAdd BLAST19
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Amyloid, Cell membraneUniRule annotation, Golgi apparatusARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Glycoprotein, GPI-anchorARBA annotation, Lipoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.

Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement.

Interacts with KIAA1191.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O46648

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini116 – 131Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST16
Domaini203 – 221Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST19

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 110DisorderedSequence analysisAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prion family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.790.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000817, Prion
IPR036924, Prion/Doppel_b-ribbon_dom_sf
IPR022416, Prion/Doppel_prot_b-ribbon_dom
IPR025860, Prion_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00377, Prion, 1 hit
PF11587, Prion_bPrPp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00341, PRION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00157, PRP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54098, SSF54098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00291, PRION_1, 1 hit
PS00706, PRION_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O46648-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN
60 70 80 90 100
RYPPQGGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GGWGQGGSHS
110 120 130 140 150
QWNKPSKPKT NMKHVAGAAA AGAVVGGLGG YMLGSAMSRP LIHFGNDYED
160 170 180 190 200
RYYRENMYRY PNQVYYRPVD QYSNQNNFVH DCVNITVKQH TVTTTTKGEN
210 220 230 240 250
FTETDIKIME RVVEQMCITQ YQRESQAYYQ RGASVILFSS PPVILLISFL

IFLIVG
Length:256
Mass (Da):27,887
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFC8E95F6FD99746
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF117316 Genomic DNA Translation: AAD19987.1
AF486136 Genomic DNA Translation: AAL93183.1
EF139167 Genomic DNA Translation: ABL75503.1
EU870890 Genomic DNA Translation: ACJ66711.1
GQ497227 Genomic DNA Translation: ACV31927.1
HM038412 Genomic DNA Translation: ADG65692.1
HM038413 Genomic DNA Translation: ADG65693.1
KP715243 mRNA Translation: AKQ12831.1
MH567632 Genomic DNA Translation: QBL57058.1
MH567636 Genomic DNA Translation: QBL57062.1
MH567644 Genomic DNA Translation: QBL57070.1
MH567646 Genomic DNA Translation: QBL57072.1
MH567649 Genomic DNA Translation: QBL57075.1
MH567652 Genomic DNA Translation: QBL57078.1
MH567653 Genomic DNA Translation: QBL57079.1
MH567655 Genomic DNA Translation: QBL57081.1
MH567660 Genomic DNA Translation: QBL57086.1
MH567665 Genomic DNA Translation: QBL57091.1
MH567676 Genomic DNA Translation: QBL57102.1
MH567687 Genomic DNA Translation: QBL57113.1
MH567704 Genomic DNA Translation: QBL57130.1
MH567714 Genomic DNA Translation: QBL57140.1
MH567715 Genomic DNA Translation: QBL57141.1
MH567772 Genomic DNA Translation: QBL57198.1
MH567805 Genomic DNA Translation: QBL57231.1
MH567828 Genomic DNA Translation: QBL57254.1
MH567829 Genomic DNA Translation: QBL57255.1
MH567846 Genomic DNA Translation: QBL57272.1
MH567867 Genomic DNA Translation: QBL57293.1
MH567879 Genomic DNA Translation: QBL57305.1
MH567891 Genomic DNA Translation: QBL57317.1
MH567944 Genomic DNA Translation: QBL57370.1
MH567951 Genomic DNA Translation: QBL57377.1
MH567970 Genomic DNA Translation: QBL57396.1
MH568005 Genomic DNA Translation: QBL57431.1
MH568048 Genomic DNA Translation: QBL57474.1
MH568080 Genomic DNA Translation: QBL57506.1
MH568097 Genomic DNA Translation: QBL57523.1
MH568104 Genomic DNA Translation: QBL57530.1
MH568152 Genomic DNA Translation: QBL57578.1
MH568156 Genomic DNA Translation: QBL57582.1
MH568157 Genomic DNA Translation: QBL57583.1
MH568165 Genomic DNA Translation: QBL57591.1
MH568176 Genomic DNA Translation: QBL57602.1
MH568201 Genomic DNA Translation: QBL57627.1
MH568212 Genomic DNA Translation: QBL57638.1
MH568214 Genomic DNA Translation: QBL57640.1
MH568270 Genomic DNA Translation: QBL57696.1
MH568280 Genomic DNA Translation: QBL57706.1
MH568291 Genomic DNA Translation: QBL57717.1
MH568369 Genomic DNA Translation: QBL57795.1
MH568410 Genomic DNA Translation: QBL57836.1
MH568413 Genomic DNA Translation: QBL57839.1
MH568414 Genomic DNA Translation: QBL57840.1
MH568415 Genomic DNA Translation: QBL57841.1
MH568445 Genomic DNA Translation: QBL57871.1
MH568453 Genomic DNA Translation: QBL57879.1
MH568470 Genomic DNA Translation: QBL57896.1
MH568499 Genomic DNA Translation: QBL57925.1
MH568501 Genomic DNA Translation: QBL57927.1
MH568505 Genomic DNA Translation: QBL57931.1
MH568528 Genomic DNA Translation: QBL57954.1
MH568567 Genomic DNA Translation: QBL57993.1
MH568577 Genomic DNA Translation: QBL58003.1
MH568582 Genomic DNA Translation: QBL58008.1
MH568590 Genomic DNA Translation: QBL58016.1
MH568624 Genomic DNA Translation: QBL58050.1
MH568635 Genomic DNA Translation: QBL58061.1
MH568636 Genomic DNA Translation: QBL58062.1
MH568639 Genomic DNA Translation: QBL58065.1
MH568651 Genomic DNA Translation: QBL58077.1
MH568660 Genomic DNA Translation: QBL58086.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A54281

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117316 Genomic DNA Translation: AAD19987.1
AF486136 Genomic DNA Translation: AAL93183.1
EF139167 Genomic DNA Translation: ABL75503.1
EU870890 Genomic DNA Translation: ACJ66711.1
GQ497227 Genomic DNA Translation: ACV31927.1
HM038412 Genomic DNA Translation: ADG65692.1
HM038413 Genomic DNA Translation: ADG65693.1
KP715243 mRNA Translation: AKQ12831.1
MH567632 Genomic DNA Translation: QBL57058.1
MH567636 Genomic DNA Translation: QBL57062.1
MH567644 Genomic DNA Translation: QBL57070.1
MH567646 Genomic DNA Translation: QBL57072.1
MH567649 Genomic DNA Translation: QBL57075.1
MH567652 Genomic DNA Translation: QBL57078.1
MH567653 Genomic DNA Translation: QBL57079.1
MH567655 Genomic DNA Translation: QBL57081.1
MH567660 Genomic DNA Translation: QBL57086.1
MH567665 Genomic DNA Translation: QBL57091.1
MH567676 Genomic DNA Translation: QBL57102.1
MH567687 Genomic DNA Translation: QBL57113.1
MH567704 Genomic DNA Translation: QBL57130.1
MH567714 Genomic DNA Translation: QBL57140.1
MH567715 Genomic DNA Translation: QBL57141.1
MH567772 Genomic DNA Translation: QBL57198.1
MH567805 Genomic DNA Translation: QBL57231.1
MH567828 Genomic DNA Translation: QBL57254.1
MH567829 Genomic DNA Translation: QBL57255.1
MH567846 Genomic DNA Translation: QBL57272.1
MH567867 Genomic DNA Translation: QBL57293.1
MH567879 Genomic DNA Translation: QBL57305.1
MH567891 Genomic DNA Translation: QBL57317.1
MH567944 Genomic DNA Translation: QBL57370.1
MH567951 Genomic DNA Translation: QBL57377.1
MH567970 Genomic DNA Translation: QBL57396.1
MH568005 Genomic DNA Translation: QBL57431.1
MH568048 Genomic DNA Translation: QBL57474.1
MH568080 Genomic DNA Translation: QBL57506.1
MH568097 Genomic DNA Translation: QBL57523.1
MH568104 Genomic DNA Translation: QBL57530.1
MH568152 Genomic DNA Translation: QBL57578.1
MH568156 Genomic DNA Translation: QBL57582.1
MH568157 Genomic DNA Translation: QBL57583.1
MH568165 Genomic DNA Translation: QBL57591.1
MH568176 Genomic DNA Translation: QBL57602.1
MH568201 Genomic DNA Translation: QBL57627.1
MH568212 Genomic DNA Translation: QBL57638.1
MH568214 Genomic DNA Translation: QBL57640.1
MH568270 Genomic DNA Translation: QBL57696.1
MH568280 Genomic DNA Translation: QBL57706.1
MH568291 Genomic DNA Translation: QBL57717.1
MH568369 Genomic DNA Translation: QBL57795.1
MH568410 Genomic DNA Translation: QBL57836.1
MH568413 Genomic DNA Translation: QBL57839.1
MH568414 Genomic DNA Translation: QBL57840.1
MH568415 Genomic DNA Translation: QBL57841.1
MH568445 Genomic DNA Translation: QBL57871.1
MH568453 Genomic DNA Translation: QBL57879.1
MH568470 Genomic DNA Translation: QBL57896.1
MH568499 Genomic DNA Translation: QBL57925.1
MH568501 Genomic DNA Translation: QBL57927.1
MH568505 Genomic DNA Translation: QBL57931.1
MH568528 Genomic DNA Translation: QBL57954.1
MH568567 Genomic DNA Translation: QBL57993.1
MH568577 Genomic DNA Translation: QBL58003.1
MH568582 Genomic DNA Translation: QBL58008.1
MH568590 Genomic DNA Translation: QBL58016.1
MH568624 Genomic DNA Translation: QBL58050.1
MH568635 Genomic DNA Translation: QBL58061.1
MH568636 Genomic DNA Translation: QBL58062.1
MH568639 Genomic DNA Translation: QBL58065.1
MH568651 Genomic DNA Translation: QBL58077.1
MH568660 Genomic DNA Translation: QBL58086.1
PIRiA54281

3D structure databases

SMRiO46648
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.790.10, 1 hit
InterProiView protein in InterPro
IPR000817, Prion
IPR036924, Prion/Doppel_b-ribbon_dom_sf
IPR022416, Prion/Doppel_prot_b-ribbon_dom
IPR025860, Prion_N_dom
PfamiView protein in Pfam
PF00377, Prion, 1 hit
PF11587, Prion_bPrPp, 1 hit
PRINTSiPR00341, PRION
SMARTiView protein in SMART
SM00157, PRP, 1 hit
SUPFAMiSSF54098, SSF54098, 1 hit
PROSITEiView protein in PROSITE
PS00291, PRION_1, 1 hit
PS00706, PRION_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO46648_CAPHI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O46648
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: October 7, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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