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Protein
Submitted name:

Pregnancy-associated glycoprotein 12

Gene

PAG12

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86PROSITE-ProRule annotation1
Active sitei267PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.094

Names & Taxonomyi

Protein namesi
Submitted name:
Pregnancy-associated glycoprotein 12Imported
Gene namesi
Name:PAG12Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501254250716 – 375Sequence analysisAdd BLAST360

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO46500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 373Peptidase A1InterPro annotationAdd BLAST306

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 44Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOGENOMiHOG000197681
HOVERGENiHBG000482
KOiK06002

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

O46500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLVLLGLV ALSECIVILP LRKMKTLRET LREKNLLNNF LEERAYRLSK
60 70 80 90 100
KDSKITIHPL KNYLDMAYVG NITIGTPPQE FRVVFDTGSA DLWVPSISCV
110 120 130 140 150
SPACYTHKTF NLHNSSSFGQ THQPISISYG PGIIQGFLGS DTVRIGNLVS
160 170 180 190 200
LKQSFGLSQE EYGFDGAPFD GVLGLAYPSI SIKGIIPIFD NLWSQGAFSE
210 220 230 240 250
PVFAFYLNTC QPEGSVVMFG GVDHRYYKGE LNWIPVSQTR YWQISMNRIS
260 270 280 290 300
MNGNVTACSR GCQALLDTGT SMIHGPTRLI TNIHKLMNAR HQGSEYVVSC
310 320 330 340 350
DAVKTLPPVI FNINGIDYPL PPQAYITKAQ NFCLSIFHGG TETSSPETWI
360 370
LGGVFLRQYF SVFDRRNDSI GLAQV
Length:375
Mass (Da):41,756
Last modified:June 1, 1998 - v1
Checksum:i96CCD89FF8CD670F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020514 mRNA Translation: AAC04685.1
RefSeqiNP_788795.1, NM_176622.1
UniGeneiBt.15984

Genome annotation databases

GeneIDi337906
KEGGibta:337906

Similar proteinsi

Entry informationi

Entry nameiO46500_BOVIN
AccessioniPrimary (citable) accession number: O46500
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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