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Protein
Submitted name:

Pregnancy-associated glycoprotein 8

Gene

PAG8

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89PROSITE-ProRule annotation1
Active sitei272PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.051

Names & Taxonomyi

Protein namesi
Submitted name:
Pregnancy-associated glycoprotein 8Imported
Gene namesi
Name:PAG8Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501326612916 – 387Sequence analysisAdd BLAST372

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO46496
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 384Peptidase A1InterPro annotationAdd BLAST314

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOVERGENiHBG000482

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

O46496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLVLLGLV ALSECIVKIP LTKMKTMQEA IREKQLLEDF LDEQPHSLSQ
60 70 80 90 100
HSDPDKKFSS HQLKNFQNAV YFGTITIGTP PQEFQVNFDT GSSDLWVPSV
110 120 130 140 150
DCQSPSCSKH KRFDPQKSTT FQPLNQKIEL VYGSGTMKGV LGSDTIQIGN
160 170 180 190 200
LVIVNQIFGL SQNQSSGVLE QVPYDGILGL AYPSLAIQGT TPVFDNLKNR
210 220 230 240 250
EVISEPVFAF YLSSRPENIS TVMFGGVDHT YHKGKLQWIP VTQARFWQVA
260 270 280 290 300
MSSMTMNGNV VGCSQGCQAV VDTGTSLLVG PTHLVTDILK LINPNPILND
310 320 330 340 350
EQMLSCDAIN SLPTLLLTIN GIVYPVPPDY YIQRFSERIC FISFQGGTEI
360 370 380
LKNLGTSETW ILGDVFLRLY FSVYDRGNNR IGLAPAA
Length:387
Mass (Da):42,891
Last modified:June 1, 1998 - v1
Checksum:iA32BA30F4B0CE51B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020510 mRNA Translation: AAC04681.1
UniGeneiBt.4125

Similar proteinsi

Entry informationi

Entry nameiO46496_BOVIN
AccessioniPrimary (citable) accession number: O46496
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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