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Protein

Regulator of G-protein signaling 9

Gene

RGS9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
Gene namesi
Name:RGS9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042021 – 484Regulator of G-protein signaling 9Add BLAST484

Post-translational modificationi

Phosphorylation is decreased by light exposition.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO46469
PRIDEiO46469

PTM databases

iPTMnetiO46469

Expressioni

Tissue specificityi

Photoreceptor outer segments.

Interactioni

Subunit structurei

Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (Probable). Interacts with PDE6G and GNAT1 (PubMed:11234020).2 Publications1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GNB5A5PJS15EBI-6949890,EBI-6949917

Protein-protein interaction databases

CORUMiO46469
IntActiO46469, 2 interactors
MINTiO46469
STRINGi9913.ENSBTAP00000023605

Structurei

Secondary structure

1484
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO46469
SMRiO46469
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO46469

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105DEPPROSITE-ProRule annotationAdd BLAST76
Domaini219 – 280G protein gammaAdd BLAST62
Domaini299 – 414RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO46469
KOiK13765

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O46469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIRHQGQQY RPRMAFLRKI EALVKDMQDP DTGVRVQNQK VKVVSIPHAM
60 70 80 90 100
TGSDVLQWIS QRLWISGLEA QNLGNFIVKY GYIYPLQDPR NLTLKPDSSL
110 120 130 140 150
YRFQTPYFWP TQQWPAEDVD YAIYLAKRNI KKKGILEEYE KENYNFLNKK
160 170 180 190 200
INYKWDFVIM QAREQYRAGK ERNKVDRCAL DCQEKAYWLV HRCPPGANNV
210 220 230 240 250
LDYGLDRVTN PNEDQKQTVV SVRKEIMYYR QALMRSTVKS SVSLGGIVKY
260 270 280 290 300
SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVDIPTK MRVERWAFNF
310 320 330 340 350
SELIRDPKGR QSFQHFLRKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI
360 370 380 390 400
YKLFLAPGAR RWINIDGKTM DITVKGLKHP HRYVLDAAQT HIYMLMKKDS
410 420 430 440 450
YARYLKSPIY KEMLAKAIEP QGTTRKSSSL PFMRRHLRSS PSPVILRQLE
460 470 480
EEAKAREAAT TVDITQVMSK LDRRSQLRKE PPPK
Length:484
Mass (Da):56,680
Last modified:June 1, 1998 - v1
Checksum:i3D8C61CEC1E22949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011357 mRNA Translation: AAC99480.1
RefSeqiNP_776595.1, NM_174170.2
UniGeneiBt.97062

Genome annotation databases

GeneIDi281453
KEGGibta:281453

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011357 mRNA Translation: AAC99480.1
RefSeqiNP_776595.1, NM_174170.2
UniGeneiBt.97062

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQIX-ray1.94A276-422[»]
1FQJX-ray2.02B/E276-422[»]
1FQKX-ray2.30B/D276-422[»]
ProteinModelPortaliO46469
SMRiO46469
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiO46469
IntActiO46469, 2 interactors
MINTiO46469
STRINGi9913.ENSBTAP00000023605

PTM databases

iPTMnetiO46469

Proteomic databases

PaxDbiO46469
PRIDEiO46469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281453
KEGGibta:281453

Organism-specific databases

CTDi8787

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO46469
KOiK13765

Miscellaneous databases

EvolutionaryTraceiO46469

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS9_BOVIN
AccessioniPrimary (citable) accession number: O46469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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