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Entry version 103 (18 Sep 2019)
Sequence version 2 (07 Jul 2009)
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Protein

Supervillin

Gene

SVIL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (By similarity).By similarity
Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6 (PubMed:16880273, PubMed:17925381). Plays a role in cytokinesis through KIF14 interaction (PubMed:20309963).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cytoskeleton organization Source: InterPro
  • positive regulation of cytokinesis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Supervillin1 Publication
Alternative name(s):
ArchvillinBy similarity
p205/p2501 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SVIL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi828 – 829RY → AA: Diminishes interaction with TRIP6 and DYNLT1. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003785151 – 2194SupervillinAdd BLAST2194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei262PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei652PhosphoserineBy similarity1
Modified residuei686PhosphoserineBy similarity1
Modified residuei747PhosphoserineBy similarity1
Modified residuei781PhosphoserineBy similarity1
Modified residuei829PhosphotyrosineBy similarity1
Modified residuei831PhosphothreonineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei899PhosphoserineBy similarity1
Modified residuei903PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
Modified residuei979PhosphoserineBy similarity1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1205PhosphoserineBy similarity1
Modified residuei1210PhosphothreonineBy similarity1
Modified residuei1214PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1385PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O46385

PRoteomics IDEntifications database

More...
PRIDEi
O46385

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with F-actin.

Interacts with NEB (By similarity).

Interacts with MYH9.

Interacts with MYLK. Isoform 2:

Interacts with TRIP6. Isoform 2:

Interacts with DYNLT1. Isoform 2:

Interacts with KIF14; at midbody during cytokinesis (PubMed:20309963).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O46385, 50 interactors

Molecular INTeraction database

More...
MINTi
O46385

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000049248

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1421 – 1520Gelsolin-like 1Add BLAST100
Repeati1540 – 1662Gelsolin-like 2Add BLAST123
Repeati1732 – 1842Gelsolin-like 3Add BLAST111
Repeati1861 – 1962Gelsolin-like 4Add BLAST102
Repeati1995 – 2102Gelsolin-like 5Add BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2131 – 2194HPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 174Interaction with MYLKAdd BLAST174
Regioni1399 – 1667Interaction with NEBBy similarityAdd BLAST269

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0445 Eukaryota
ENOG410XPWY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154653

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O46385

KEGG Orthology (KO)

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KOi
K10369

Database of Orthologous Groups

More...
OrthoDBi
1376537at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit
3.40.20.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 5 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O46385-1) [UniParc]FASTAAdd to basket
Also known as: ArchvillinBy similarity, p250By similarity

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRKERIARR LEGIETDTQP ILLQSCTGLV THRLLEEDTP RYMRATDPAS
60 70 80 90 100
PHIGRSNEEE ETSDSSLEKQ TRSKQCTETS GIHADSPYSS GIMDTQSLES
110 120 130 140 150
KAERIARYKA ERRRQLAEKY GLTLDPEADS ETPSRYSRSR KDPEAAEKRG
160 170 180 190 200
VRSERSAESS RDAGSSYSRT ELSGLRTCVA ESKDYGLHRS DGVSDTEVLL
210 220 230 240 250
NAENQRRGQE PSATGLARDL PLAGEVSSSF SFSGRDSALG EVPRSPKAVH
260 270 280 290 300
SLPSPSPGQP ASPSHSTSDL PLPAEARASI GKPKHEWFLQ KDSEGDTPSL
310 320 330 340 350
INWPSRVKVR EKLVREESAR SSPELTSESL TQRRHQTAPG HYLAFQSENS
360 370 380 390 400
AFDRVSGKVA SSARQPIRGY VQPAEPVHTI TLVTSDTPES ISEGSWVGPA
410 420 430 440 450
PQTVTKPPPS KVLEGERRDT PVLHICESKA EDVLFSDALE KTRKTLAVLE
460 470 480 490 500
DRGSGRSQEA PSGTEDLSQP AVGIVTAEPQ KESESLAHPP MAQQQPTERM
510 520 530 540 550
GRSEMVMYVQ SEAVSQGHRK EVPTRKHRVL TRSLSDYTGP PQLQALKAKA
560 570 580 590 600
PAPKRDAESQ TSKAELELGL LDTKVSVAQL RNAFLESARA SRKPELHSRV
610 620 630 640 650
EGSSEGPGVE RERGSRKPRR YFSPGENRKT SERFRTQPIT SAERKESDRS
660 670 680 690 700
TSNSEMPAAE DEEKVDERAR LSVAAKRLLF REMEKSFDEK SVPKRRSRNA
710 720 730 740 750
AVEQRLRRLQ DRSHTQPVTT EEVVIAAEPT PASCSVATHP VMTRHPSPTV
760 770 780 790 800
AKSPVQPART LQASAHQKAL ARDQTNESKD SAEQGEPDSS TLSLAEKLAL
810 820 830 840 850
FNKLSQPVSK AISTRNRLDM RQRRMNARYQ TQPVTLGEVE QVQSGKLMAF
860 870 880 890 900
SPTINTSVST VASTVPPMYA GNLRTKPLPD DSFGATEQKF ASSLENSDSP
910 920 930 940 950
VRSILKSQGW QPSVEGAGSK AMLREFEETE RKGGLTGGDG GVTKYGSFEE
960 970 980 990 1000
AELSYPVLSR VREGDNHKEA IYALPRKGSL ELAHPPIAQL GDDLKEFSTP
1010 1020 1030 1040 1050
KSTMQASPDW KERQLFEEKV DLENVTKRKF SLKAAEFGEP TSEQTGAAAG
1060 1070 1080 1090 1100
KPAAPTATPV SWKPQDPSEQ PQEKRYQSPC AMFAAGEIKA PAVEGSLDSP
1110 1120 1130 1140 1150
SKTMSIKERL ALLKKSGEED WRNRLNRKQE YGKASITSSL HIQETEQSLK
1160 1170 1180 1190 1200
KKRVTESRES QMTIEERKHL ITVREDAWKT RGKGAANDST QFTVAGRMVK
1210 1220 1230 1240 1250
RGLASPTAIT PVASPVSSKA RGTTPVSRPL EDIEARPDMQ LESDLKLDRL
1260 1270 1280 1290 1300
ETFLRRLNNK VGGMQETVLT VTGKSVKEVM KPDDDETFAK FYRSVDSSLP
1310 1320 1330 1340 1350
RSPVELDEDF DVIFDPYAPR LTSSVAEHKR AVRPKRRVQA SKNPLKMLAA
1360 1370 1380 1390 1400
REDLLQEYTE QRLNVAFVES KRMKVEKLSA NSSFSEVTLA GLASKENFSN
1410 1420 1430 1440 1450
VSLRSVNLTE QNSNNSAVPY KKLMLLQVKG RRHVQTRLVE PRAPSLNSGD
1460 1470 1480 1490 1500
CFLLLSPHHC FLWVGEFANV IEKAKASELA SLIQTKRELG CRATYIQTVE
1510 1520 1530 1540 1550
EGINTHTHAA KDFWKLLGGQ ASYQSAGDPK EDELYETAII ETNCIYRLMD
1560 1570 1580 1590 1600
DKLVPDDDYW GKIPKCSLLQ SKEVLVFDFG SEVYVWHGKE VTLAQRKIAF
1610 1620 1630 1640 1650
QLAKHLWNGT FDYENCDINP LDPGECNPLI PRKGQGRPDW AIFGRLTEHN
1660 1670 1680 1690 1700
ETILFKEKFL DWTELKRPNE KNASELAQHK DDARAEVKPY DVTRMVPVPQ
1710 1720 1730 1740 1750
TTAGTVLDGV NVGRGYGLVE GDDRRQFEIA SISVDVWHIL EFDYSRLPKQ
1760 1770 1780 1790 1800
SIGQFHEGDA YVVKWKFIVS TAVGSRQKGE HSVRVAGKEK CVYFFWQGRQ
1810 1820 1830 1840 1850
STVSEKGTSA LMTVELDEER GAQVQVLQGK EPPCFLQCFQ GGMVVHSGRR
1860 1870 1880 1890 1900
EEEEENTQSE WRLYCVRGEV PVEGNLLEVA CHCSSLRSRT SMVVLNVHKA
1910 1920 1930 1940 1950
LIYLWHGCKA QAHTKEVGRT AANKIKDQCP LEAGLHSSSK VTIHECDEGS
1960 1970 1980 1990 2000
EPLGFWDALG RRDRKAYDCM LQDPGNFNFT PRLFILSSSS GDFSATEFMY
2010 2020 2030 2040 2050
PARDPSVVNS MPFLQEDLYS APQPALFLVD NHHEVYLWQG WWPIENKITG
2060 2070 2080 2090 2100
SARIRWASDR KSAMETVLQY CRGKNLKKPP PKSYLIHAGL EPLTFTNMFP
2110 2120 2130 2140 2150
SWEHREDIAE ITEMDTEVSN QITLVEDVLA KLCKTIYPLA DLLARPLPEG
2160 2170 2180 2190
VDPLKLEIYL TDEDFEFALD MTRDEYNALP AWKQVNLKKA KGLF
Length:2,194
Mass (Da):244,892
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i345C450DC2D8516C
GO
Isoform 2 (identifier: O46385-2) [UniParc]FASTAAdd to basket
Also known as: Supervillin1 Publication, p2051 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     279-648: Missing.
     728-759: Missing.

Show »
Length:1,792
Mass (Da):200,627
Checksum:iE7683787B0187DA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MIU5F1MIU5_BOVIN
Supervillin
SVIL
2,174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1BK07E1BK07_BOVIN
Supervillin
SVIL
1,864Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037598279 – 648Missing in isoform 2. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_037599728 – 759Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF025996 mRNA Translation: AAC48783.1
AAFC03127701 Genomic DNA No translation available.
AAFC03076280 Genomic DNA No translation available.
AAFC03076281 Genomic DNA No translation available.
AAFC03076282 Genomic DNA No translation available.
DV816343 mRNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
T08878

NCBI Reference Sequences

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RefSeqi
NP_776615.1, NM_174190.2 [O46385-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000027592; ENSBTAP00000027592; ENSBTAG00000027444 [O46385-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
281509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281509

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025996 mRNA Translation: AAC48783.1
AAFC03127701 Genomic DNA No translation available.
AAFC03076280 Genomic DNA No translation available.
AAFC03076281 Genomic DNA No translation available.
AAFC03076282 Genomic DNA No translation available.
DV816343 mRNA No translation available.
PIRiT08878
RefSeqiNP_776615.1, NM_174190.2 [O46385-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiO46385, 50 interactors
MINTiO46385
STRINGi9913.ENSBTAP00000049248

Proteomic databases

PaxDbiO46385
PRIDEiO46385

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027592; ENSBTAP00000027592; ENSBTAG00000027444 [O46385-2]
GeneIDi281509
KEGGibta:281509

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6840

Phylogenomic databases

eggNOGiKOG0445 Eukaryota
ENOG410XPWY LUCA
GeneTreeiENSGT00940000154653
InParanoidiO46385
KOiK10369
OrthoDBi1376537at2759

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 5 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 5 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVIL_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O46385
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 18, 2019
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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