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UniProtKB - O46375 (TTHY_BOVIN)
Protein
Transthyretin
Gene
TTR
Organism
Bos taurus (Bovine)
Status
Functioni
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | L-thyroxineBy similarity | 1 | |
Binding sitei | 74 | L-thyroxineBy similarity | 1 |
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- thyroid hormone binding Source: GO_Central
GO - Biological processi
- purine nucleobase metabolic process Source: GO_Central
- retinol metabolic process Source: InterPro
- thyroid hormone transport Source: InterPro
Keywordsi
Molecular function | Hormone, Thyroid hormone |
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: TransthyretinAlternative name(s): Prealbumin |
Gene namesi | Name:TTR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000010991 |
VGNCi | VGNC:36499, TTR |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000035753 | 21 – 147 | TransthyretinAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 62 | 4-carboxyglutamateBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Gamma-carboxyglutamic acid, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | O46375 |
PeptideAtlasi | O46375 |
PRIDEi | O46375 |
Expressioni
Tissue specificityi
Detected in serum (at protein level).1 Publication
Gene expression databases
Bgeei | ENSBTAG00000010991, Expressed in liver and 91 other tissues |
ExpressionAtlasi | O46375, baseline and differential |
Interactioni
Subunit structurei
Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules.
Interacts with RBP4.
1 PublicationGO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014585 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 139 | L-thyroxine bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the transthyretin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3006, Eukaryota |
GeneTreei | ENSGT00940000153229 |
HOGENOMi | CLU_115536_2_0_1 |
InParanoidi | O46375 |
OMAi | TWEPFAT |
OrthoDBi | 1453185at2759 |
TreeFami | TF300210 |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR023418, Thyroxine_BS IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O46375-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASFRLFLLC LAGLVFVSEA GSVGAGEPKC PLMVKVLDAV RGSPAANVGV
60 70 80 90 100
KVFKKAADET WEPFASGKTS ESGELHGLTT EDKFVEGLYK VELDTKSYWK
110 120 130 140
SLGISPFHEF AEVVFTANDS GPRHYTIAAL LSPYSYSTTA LVSSPKA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MRM2 | A0A3Q1MRM2_BOVIN | Transthyretin | TTR | 181 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009591 mRNA Translation: BAA23983.1 BC103035 mRNA Translation: AAI03036.1 |
RefSeqi | NP_776392.1, NM_173967.3 |
Genome annotation databases
Ensembli | ENSBTAT00000014585; ENSBTAP00000014585; ENSBTAG00000010991 |
GeneIDi | 280948 |
KEGGi | bta:280948 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009591 mRNA Translation: BAA23983.1 BC103035 mRNA Translation: AAI03036.1 |
RefSeqi | NP_776392.1, NM_173967.3 |
3D structure databases
AlphaFoldDBi | O46375 |
SMRi | O46375 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014585 |
Proteomic databases
PaxDbi | O46375 |
PeptideAtlasi | O46375 |
PRIDEi | O46375 |
Genome annotation databases
Ensembli | ENSBTAT00000014585; ENSBTAP00000014585; ENSBTAG00000010991 |
GeneIDi | 280948 |
KEGGi | bta:280948 |
Organism-specific databases
CTDi | 7276 |
VEuPathDBi | HostDB:ENSBTAG00000010991 |
VGNCi | VGNC:36499, TTR |
Phylogenomic databases
eggNOGi | KOG3006, Eukaryota |
GeneTreei | ENSGT00940000153229 |
HOGENOMi | CLU_115536_2_0_1 |
InParanoidi | O46375 |
OMAi | TWEPFAT |
OrthoDBi | 1453185at2759 |
TreeFami | TF300210 |
Gene expression databases
Bgeei | ENSBTAG00000010991, Expressed in liver and 91 other tissues |
ExpressionAtlasi | O46375, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR023418, Thyroxine_BS IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TTHY_BOVIN | |
Accessioni | O46375Primary (citable) accession number: O46375 Secondary accession number(s): Q3SZ91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families