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UniProtKB - O46339 (HTH_DROME)

Entry version 176 (29 Sep 2021)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
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Protein

Homeobox protein homothorax

Gene

hth

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive 'dorsal rim area' (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision.

5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi365 – 427Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-390193, Transcriptional activation by YKI

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O46339

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein homothorax
Alternative name(s):
Homeobox protein dorsotonals
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hthImported
Synonyms:dtlImported
ORF Names:CG17117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0001235, hth

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0001235

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe head defects, including a failure of head involution and transformation of the thoracic and abdominal segments into a more posterior identity.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003414841 – 487Homeobox protein homothoraxAdd BLAST487

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O46339

PRoteomics IDEntifications database

More...PRIDEi		O46339

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the wing disk, the expression is present in the regions corresponding to notum, wing hinge and ventral pleura. In the leg disk, the expression is in the periphery region, corresponding to the proximal segments of the legs. In the antennal disk, the expression is in all but the arista region. In the eye disk, the expression is strong in the anterior region surrounding the eye field, including the regions corresponding to ptilinum, ocellus and head capsules, and weak in the posterior and lateral margins of the eye disk. Expressed specifically in maturating inner photoreceptors of the DRA and maintained through adulthood.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform C, isoform E and isoform F have very similar expression patterns during embryonic and larval stages, suggesting coexpression in the same tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0001235, Expressed in central nervous system and 71 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O46339, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O46339, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with exd; required for nuclear translocation of exd.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		66419, 45 interactors

Protein interaction database and analysis system

More...IntActi		O46339, 64 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0081732

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O46339

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 49DisorderedSequence analysisAdd BLAST25
Regioni210 – 292DisorderedSequence analysisAdd BLAST83
Regioni333 – 369DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi223 – 254Polar residuesSequence analysisAdd BLAST32
Compositional biasi266 – 292Polar residuesSequence analysisAdd BLAST27
Compositional biasi333 – 350Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0773, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168996

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O46339

Identification of Orthologs from Complete Genome Data

More...OMAi		PPEYYGH

Database for complete collections of gene phylogenies

More...PhylomeDBi		O46339

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
IPR032453, PKNOX/Meis_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05920, Homeobox_KN, 1 hit
PF16493, Meis_PKNOX_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform C2 Publications (identifier: O46339-1) [UniParc]FASTAAdd to basket
Also known as: hth11 Publication, HthFL1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQPRYDDGL HGYGMDSGAA AAAMYDPHAG HRPPGLQGLP SHHSPHMTHA 
        60         70         80         90        100
AAAAATVGMH GYHSGAGGHG TPSHVSPVGN HLMGAIPEVH KRDKDAIYEH 
       110        120        130        140        150
PLFPLLALIF EKCELATCTP REPGVQGGDV CSSESFNEDI AMFSKQIRSQ 
       160        170        180        190        200
KPYYTADPEV DSLMVQAIQV LRFHLLELEK VHELCDNFCH RYISCLKGKM 
       210        220        230        240        250
PIDLVIDERD TTKPPELGSA NGEGRSNADS TSHTDGASTP DVRPPSSSLS 
       260        270        280        290        300
YGGAMNDDAR SPGAGSTPGP LSQQPPALDT SDPDGKFLSS LNPSELTYDG 
       310        320        330        340        350
RWCRREWSSP ADARNADASR RLYSSVFLGS PDNFGTSASG DASNASIGSG 
       360        370        380        390        400
EGTGEEDDDA SGKKNQKKRG IFPKVATNIL RAWLFQHLTH PYPSEDQKKQ 
       410        420        430        440        450
LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRAVYTPHP GPSGYGHDAM 
       460        470        480 
GYMMDSQAHM MHRPPGDPGF HQGYPHYPPA EYYGQHL
Length:487
Mass (Da):52,784
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EA4D7D1EFB16F8A
GO
Isoform A1 Publication (identifier: O46339-2) [UniParc]FASTAAdd to basket
Also known as: hth21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     284-398: Missing.

Show »
Length:372
Mass (Da):40,219
Checksum:i02F04B6DE5C19565
GO
Isoform E1 Publication (identifier: O46339-5) [UniParc]FASTAAdd to basket
Also known as: HDless 7'1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     243-266: RPPSSSLSYGGAMNDDARSPGAGS → PSTQDFSPLEETYASYRIKHEADF
     267-487: Missing.

Note: Protein lacks the homeodomain but is still capable of interacting with exd.1 Publication
Show »
Length:266
Mass (Da):28,867
Checksum:iBEDFA03DB6BC2AB2
GO
Isoform F1 Publication (identifier: O46339-6) [UniParc]FASTAAdd to basket
Also known as: HDless 6'1 Publication, IImported

The sequence of this isoform differs from the canonical sequence as follows:
     243-266: RPPSSSLSYGGAMNDDARSPGAGS → VSTPFAGAHGPILASYNAVVHPCS
     267-487: Missing.

Note: Protein lacks the homeodomain but is still capable of interacting with exd.1 Publication
Show »
Length:266
Mass (Da):28,431
Checksum:i6F7B0554A98FA4A9
GO
Isoform H1 Publication (identifier: O46339-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.
     284-398: Missing.

Show »
Length:358
Mass (Da):38,657
Checksum:i47B1C910C9076A19
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ23556 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0528211 – 14Missing in isoform H. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_052822243 – 266RPPSS…PGAGS → PSTQDFSPLEETYASYRIKH EADF in isoform E. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_052823243 – 266RPPSS…PGAGS → VSTPFAGAHGPILASYNAVV HPCS in isoform F. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_052824267 – 487Missing in isoform E and isoform F. 2 PublicationsAdd BLAST221
Alternative sequenceiVSP_052826284 – 398Missing in isoform A and isoform H. 4 PublicationsAdd BLAST115

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF026788 mRNA Translation: AAC47759.1
AF032865 mRNA Translation: AAB97169.1
AF035825 mRNA Translation: AAB88514.1
AF036584 mRNA Translation: AAB88863.1
AE014297 Genomic DNA Translation: AAF54533.2
AE014297 Genomic DNA Translation: AAN13474.1
AE014297 Genomic DNA Translation: AAN13475.2
AE014297 Genomic DNA Translation: AAX52943.2
AE014297 Genomic DNA Translation: AAZ52527.1
BT010238 mRNA Translation: AAQ23556.1 Frameshift.
BT024210 mRNA Translation: ABC86272.1
BT029117 mRNA Translation: ABJ17050.1

NCBI Reference Sequences

More...RefSeqi		NP_001014613.2, NM_001014613.3 [O46339-5]
NP_001027170.1, NM_001031999.2 [O46339-6]
NP_476576.1, NM_057228.5 [O46339-1]
NP_476577.3, NM_057229.5 [O46339-6]
NP_476578.3, NM_057230.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0082255; FBpp0081732; FBgn0001235 [O46339-1]
FBtr0100454; FBpp0099878; FBgn0001235 [O46339-5]
FBtr0100455; FBpp0099879; FBgn0001235 [O46339-6]
FBtr0344145; FBpp0310558; FBgn0001235 [O46339-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		41273

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG17117

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026788 mRNA Translation: AAC47759.1
AF032865 mRNA Translation: AAB97169.1
AF035825 mRNA Translation: AAB88514.1
AF036584 mRNA Translation: AAB88863.1
AE014297 Genomic DNA Translation: AAF54533.2
AE014297 Genomic DNA Translation: AAN13474.1
AE014297 Genomic DNA Translation: AAN13475.2
AE014297 Genomic DNA Translation: AAX52943.2
AE014297 Genomic DNA Translation: AAZ52527.1
BT010238 mRNA Translation: AAQ23556.1 Frameshift.
BT024210 mRNA Translation: ABC86272.1
BT029117 mRNA Translation: ABJ17050.1
RefSeqiNP_001014613.2, NM_001014613.3 [O46339-5]
NP_001027170.1, NM_001031999.2 [O46339-6]
NP_476576.1, NM_057228.5 [O46339-1]
NP_476577.3, NM_057229.5 [O46339-6]
NP_476578.3, NM_057230.6

3D structure databases

SMRiO46339
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi66419, 45 interactors
IntActiO46339, 64 interactors
STRINGi7227.FBpp0081732

Proteomic databases

PaxDbiO46339
PRIDEiO46339

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		41273

Genome annotation databases

EnsemblMetazoaiFBtr0082255; FBpp0081732; FBgn0001235 [O46339-1]
FBtr0100454; FBpp0099878; FBgn0001235 [O46339-5]
FBtr0100455; FBpp0099879; FBgn0001235 [O46339-6]
FBtr0344145; FBpp0310558; FBgn0001235 [O46339-6]
GeneIDi41273
KEGGidme:Dmel_CG17117

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		41273
FlyBaseiFBgn0001235, hth
VEuPathDBiVectorBase:FBgn0001235

Phylogenomic databases

eggNOGiKOG0773, Eukaryota
GeneTreeiENSGT00940000168996
InParanoidiO46339
OMAiPPEYYGH
PhylomeDBiO46339

Enzyme and pathway databases

ReactomeiR-DME-390193, Transcriptional activation by YKI
SignaLinkiO46339

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		41273, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		hth, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		41273

Protein Ontology

More...PROi		PR:O46339

Gene expression databases

BgeeiFBgn0001235, Expressed in central nervous system and 71 other tissues
ExpressionAtlasiO46339, baseline and differential
GenevisibleiO46339, DM

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
IPR032453, PKNOX/Meis_N
PfamiView protein in Pfam
PF05920, Homeobox_KN, 1 hit
PF16493, Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTH_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O46339
Secondary accession number(s): O17427
, Q058V1, Q4AB34, Q59DX7, Q6NR42, Q7KQ21, Q8INL5, Q8INL6, Q9VGY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 1998
Last modified: September 29, 2021
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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