UniProtKB - O46166 (TXI1_ERAAG)
Protein
U1-agatoxin-Ta1a
Gene
N/A
Organism
Eratigena agrestis (Hobo spider) (Tegenaria agrestis)
Status
Functioni
Toxin that paralyzes insects. May have a direct effect on the insect central nervous system.1 Publication
Miscellaneous
Arose via modification of ancestral neuropeptide hormones (ion transport peptide/crustacean hyperglycemic hormones (ITP/CHH)).1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: U1-agatoxin-Ta1a1 PublicationShort name: U1-AGTX-Ta1a1 Publication Alternative name(s): Insecticidal toxin 11 Publication Short name: TaITX-11 Publication |
Organismi | Eratigena agrestis (Hobo spider) (Tegenaria agrestis) |
Taxonomic identifieri | 1686644 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Araneomorphae › Entelegynae › Agelenidae › Eratigena |
Organism-specific databases
ArachnoServeri | AS000349 U1-agatoxin-Ta1a |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 198 +- 33 pmol/g when injected into the ventro-lateral thoracic region of adult blowflies (L.cuprina) (lethality measured after 24 hours) (PubMed:26073605). PD50 is 0.89 nmol/g when injected into tobacco budworm, 0.78 nmol/g when injected into cabbage looper, 0.9 nmol/g when injected into beet army worm and 2.0 nmol/g when injected into Southern corn rootworm (PubMed:9589602).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | 1 PublicationAdd BLAST | 17 | |
ChainiPRO_0000035555 | 18 – 67 | U1-agatoxin-Ta1aAdd BLAST | 50 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 23 ↔ 53 | 1 Publication | ||
Disulfide bondi | 39 ↔ 49 | 1 Publication | ||
Disulfide bondi | 42 ↔ 62 | 1 Publication | ||
Modified residuei | 67 | Lysine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KSL | NMR | - | A | 18-67 | [»] | |
SMRi | O46166 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O46166 |
Family & Domainsi
Domaini
Is exclusively composed of 4 tightly packed alpha helices (no beta strand is present).1 Publication
Sequence similaritiesi
Belongs to the helical arthropod-neuropeptide-derived (HAND) family.1 Publication
Keywords - Domaini
Signali Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O46166-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLQLMICLV LLPCFFCEPD EICRARMTHK EFNYKSNVCN GCGDQVAACE
60
AECFRNDVYT ACHEAQKG
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ224127 mRNA Translation: CAA11839.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ224127 mRNA Translation: CAA11839.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KSL | NMR | - | A | 18-67 | [»] | |
SMRi | O46166 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ArachnoServeri | AS000349 U1-agatoxin-Ta1a |
Miscellaneous databases
EvolutionaryTracei | O46166 |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | TXI1_ERAAG | |
Accessioni | O46166Primary (citable) accession number: O46166 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | November 22, 2017 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references