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Protein

Serine protease inhibitor 3

Gene
N/A
Organism
Schistocerca gregaria (Desert locust)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In vitro, active against alpha-chymotrypsin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei49 – 50Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI19.012

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor 3
Alternative name(s):
Protease inhibitor SGPI-3
Serine protease inhibitor III
OrganismiSchistocerca gregaria (Desert locust)
Taxonomic identifieri7010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraPolyneopteraOrthopteraCaeliferaAcridideaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PeptideiPRO_000002671224 – 63Serine protease inhibitor 3Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi37 ↔ 47PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO46163

Expressioni

Tissue specificityi

Expressed in hemolymph, ovaries, testes and fat body of adults but are absent in the gut. Also present in larval hemolymph and fat body.1 Publication

Structurei

3D structure databases

SMRiO46163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 55PacifastinPROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the protease inhibitor I19 family. [View classification]PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiView protein in InterPro
IPR008037 Pacifastin_dom
IPR036201 Pacifastin_dom_sf
IPR016307 Prtase-inh_pacifastin
PfamiView protein in Pfam
PF05375 Pacifastin_I, 1 hit
PIRSFiPIRSF001625 Prot_inhib_pacifastin, 1 hit
SUPFAMiSSF57283 SSF57283, 1 hit
PROSITEiView protein in PROSITE
PS51446 PACIFASTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLAVFLV LLIAALVCEQ ALACTPGSRK YDGCNWCTCS SGGAWICTLK
60
YCPPSSGGGL TFA
Length:63
Mass (Da):6,533
Last modified:June 1, 1998 - v1
Checksum:iEE46BACCD7441A6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09606 mRNA Translation: CAA70819.1

Entry informationi

Entry nameiSGP3_SCHGR
AccessioniPrimary (citable) accession number: O46163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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