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UniProtKB - O46099 (O46099_DROME)

Entry version 181 (19 Jan 2022)
Sequence version 2 (01 Nov 1999)
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Protein
Submitted name:

EG:8D8.2 protein

Gene

EG:8D8.2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-216083, Integrin cell surface interactions
R-DME-3000170, Syndecan interactions
R-DME-3000178, ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
EG:8D8.2 proteinImported
Submitted name:
LP20834pImported
Submitted name:
Uncharacterized protein, isoform BImported
Submitted name:
Uncharacterized protein, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EG:8D8.2Imported
Synonyms:CG11409-RBImported, Dmel\CG11409Imported
ORF Names:CG11409Imported, Dmel_CG11409Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0024366, CG11409

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0024366

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509677721 – 1279Sequence analysisAdd BLAST1259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0024366, Expressed in embryo and 35 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-19147N

Protein interaction database and analysis system

More...IntActi		O46099, 4 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0070228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni347 – 374DisorderedSequence analysisAdd BLAST28
Regioni393 – 428DisorderedSequence analysisAdd BLAST36
Regioni496 – 565DisorderedSequence analysisAdd BLAST70
Regioni599 – 630DisorderedSequence analysisAdd BLAST32
Regioni808 – 837DisorderedSequence analysisAdd BLAST30
Regioni868 – 898DisorderedSequence analysisAdd BLAST31
Regioni929 – 986DisorderedSequence analysisAdd BLAST58
Regioni1024 – 1056DisorderedSequence analysisAdd BLAST33
Regioni1136 – 1237DisorderedSequence analysisAdd BLAST102

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1085 – 1115Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi400 – 426Polar residuesSequence analysisAdd BLAST27
Compositional biasi496 – 561Polar residuesSequence analysisAdd BLAST66
Compositional biasi609 – 630Polar residuesSequence analysisAdd BLAST22
Compositional biasi808 – 822Polar residuesSequence analysisAdd BLAST15
Compositional biasi929 – 968Polar residuesSequence analysisAdd BLAST40
Compositional biasi1139 – 1162Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1163 – 1177Polar residuesSequence analysisAdd BLAST15
Compositional biasi1193 – 1211Polar residuesSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S6AB, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_269389_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		GERQSYQ

Database of Orthologous Groups

More...OrthoDBi		316257at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O46099-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRECLALIA LLQLGGVTRA LPTIQGGNAR QQLDKSFFQP PEIEQTIDEV 
        60         70         80         90        100
QKILANDPAL PRLTRGEIEE LYEKVTREEY EKSLEAGDMS RADSMRALML 
       110        120        130        140        150
VLPFNTDNNT EENLQELYTR PPVTRVIDAY TPPDPVKFLT ADPSALPRST 
       160        170        180        190        200
VPGGNPAVAA TTYKPAYSLL HGQANPLQQQ FRPMPQATTY HPPAPPPVVY 
       210        220        230        240        250
QDFKPVTAAS QPSANPAAAP SAARFSSHYS AKNAQFLRKP KPSEGGGGSL 
       260        270        280        290        300
SSTVKPVADI LESLGIVSGG KSDSAHKRYA LDDYYPAESA PQPSVVAVAD 
       310        320        330        340        350
LRGLHGARIR PEAYSNFKPL NIGEELRVKP EVEGYLTRFG IVRKAPKALK 
       360        370        380        390        400
KEAKPTEEPT GAHTELSTAT ARLPPTGNAE LAKLLENLQE LERLQSQPKR 
       410        420        430        440        450
KTPKSTTTST TTTTTSTTTT TTPAPVPLIT HGEPLLIEAK KPRRRIDPNI 
       460        470        480        490        500
DINFANGGNQ QATPTGSDEL SKLLQNLQEL EKLKINPENV IKAASPGVQS 
       510        520        530        540        550
LSSRFSTTST STSTTTTTTT TPSPSQNEAR ELQRILKQLQ QLDQSSRTTT 
       560        570        580        590        600
STTSTTAKPL RNQALGLGVG QGNSLGAADL LQLQRLLSDD RELEKLYEQA 
       610        620        630        640        650
RNSKKKQHPK TTSSTTSTTS TTTTPRPTPS VDHAQFEALI TRVQQLEQLQ 
       660        670        680        690        700
QPTTQPNFLT RNVAGSRPVI SLPSNDYAHL QELSPTSASL LPGGGTVEIS 
       710        720        730        740        750
TAASTTKQRP LSQFERTNGL LREEVHPQDY VQLQKLLSKV QELERVQLRT 
       760        770        780        790        800
EHVTHPHSQL VTAASIRSPN VKTVNGAHIV YAQPARDQVV ELEPELKLDL 
       810        820        830        840        850
PVYEKPVTMA TPSQSSSEEL RELAMSQPAH PQRGSSADFG QFQQFFGSLE 
       860        870        880        890        900
DTGERQSYQH MQPIYKTVQN QPPTTPAAPR FVPARRAPTT PSSGPRKGDL 
       910        920        930        940        950
EELQKLLYNT QQLQKLGVAL PHELSQQLES QLQATSSSTS STTTTTTSTT 
       960        970        980        990       1000
PAPAQVHDTS SPAVFSLTTS RPRVRPIPEA KPTTESSLQL PVFSATKIIE 
      1010       1020       1030       1040       1050
AAIKRAANRI GVSTELAPKQ GLPSELAKGL GVGSGFRRRS DEGDAEDLNE 
      1060       1070       1080       1090       1100
GDEREGELDG DLMAEFSEFN YQLAKPEPEA PKEKRDDSKS NLSELQRLIS 
      1110       1120       1130       1140       1150
NLQELQQLNV SLDQVTTATS SPRPNPDAAY LQSLQSGQDE TLKERRQSVE 
      1160       1170       1180       1190       1200
NVTTESGKQK DGDDPPPTTQ SPTKISLSLG LDDIDGDTKG AVGEDDSSST 
      1210       1220       1230       1240       1250
STTTTTEEPR NGSLDDLADS FGPDPVSEEP PPPKKKNGFY FLADWNSFLE 
      1260       1270 
VGDGDDQVVV RLSPKIGDPR LFLPVKIPS
Length:1,279
Mass (Da):139,071
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA96DBBA48C5D5E9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45604.1
BT044536 mRNA Translation: ACH95310.1
AE014298 Genomic DNA Translation: AHN59243.1
AL022018 Genomic DNA Translation: CAA17685.2

Protein sequence database of the Protein Information Resource

More...PIRi		T13613

NCBI Reference Sequences

More...RefSeqi		NP_001284772.1, NM_001297843.1
NP_569902.2, NM_130546.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0070238; FBpp0070228; FBgn0024366
FBtr0342730; FBpp0309598; FBgn0024366

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG11409

UCSC genome browser

More...UCSCi		CG11409-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45604.1
BT044536 mRNA Translation: ACH95310.1
AE014298 Genomic DNA Translation: AHN59243.1
AL022018 Genomic DNA Translation: CAA17685.2
PIRiT13613
RefSeqiNP_001284772.1, NM_001297843.1
NP_569902.2, NM_130546.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-19147N
IntActiO46099, 4 interactors
STRINGi7227.FBpp0070228

Genome annotation databases

EnsemblMetazoaiFBtr0070238; FBpp0070228; FBgn0024366
FBtr0342730; FBpp0309598; FBgn0024366
GeneIDi31078
KEGGidme:Dmel_CG11409
UCSCiCG11409-RB, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0024366, CG11409
VEuPathDBiVectorBase:FBgn0024366

Phylogenomic databases

eggNOGiENOG502S6AB, Eukaryota
HOGENOMiCLU_269389_0_0_1
OMAiGERQSYQ
OrthoDBi316257at2759

Enzyme and pathway databases

ReactomeiR-DME-216083, Integrin cell surface interactions
R-DME-3000170, Syndecan interactions
R-DME-3000178, ECM proteoglycans

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		31078, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31078

Gene expression databases

BgeeiFBgn0024366, Expressed in embryo and 35 other tissues

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO46099_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O46099
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: November 1, 1999
Last modified: January 19, 2022
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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