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UniProtKB - O46091 (O46091_DROME)
Protein
alpha-1,2-Mannosidase
Gene
Edem1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: FlyBase
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- determination of adult lifespan Source: FlyBase
- endoplasmic reticulum mannose trimming Source: InterPro
- endoplasmic reticulum unfolded protein response Source: FlyBase
- mannose trimming involved in glycoprotein ERAD pathway Source: InterPro
- ubiquitin-dependent ERAD pathway Source: FlyBase
Keywordsi
Molecular function | GlycosidaseUniRule annotation, Hydrolase |
Protein family/group databases
CAZyi | GH47, Glycoside Hydrolase Family 47 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:CG3810Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Organism-specific databases
FlyBasei | FBgn0023511, Edem1 |
VEuPathDBi | VectorBase:FBgn0023511 |
Subcellular locationi
Endoplasmic reticulum
Other locations
- membrane Source: InterPro
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5004159257 | 30 – 995 | alpha-1,2-MannosidaseSequence analysisAdd BLAST | 966 |
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | O46091 |
Expressioni
Gene expression databases
Bgeei | FBgn0023511, Expressed in embryonic/larval hemocyte (Drosophila) and 34 other tissues |
ExpressionAtlasi | O46091, baseline and differential |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 545 – 567 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 843 – 899 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 545 – 562 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 861 – 899 | Polar residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_003818_5_2_1 |
OMAi | NTTAMQE |
PhylomeDBi | O46091 |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR044674, EDEM1/2/3 IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases |
PANTHERi | PTHR45679, PTHR45679, 1 hit |
Pfami | View protein in Pfam PF01532, Glyco_hydro_47, 1 hit |
PRINTSi | PR00747, GLYHDRLASE47 |
SUPFAMi | SSF48225, SSF48225, 1 hit |
i Sequence
Sequence statusi: Complete.
O46091-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQKPRNNGY PGTLICAVLL VLLSTGVSGQ KQYSKARKLE LREDVRRMFQ
60 70 80 90 100
HAYDGYLRHA SNYDELRPLT CDGHDTWGSY SLTLIDALDT LATMGNFTEF
110 120 130 140 150
RRAARLLEEK MDFDRDINVS VFETNIRIVG GLLSAHLLSK RAGVELEPGW
160 170 180 190 200
PCKGPLLRLA EDVARRLLPA FVTNTGMPYG TVNLRYGVPK GETSITCTAG
210 220 230 240 250
VGTFLIEFGT LSRLTGKTIY EDVAMKAVHA LWAYRSPIGL FGNHIDVQSG
260 270 280 290 300
RWTALDSGIG AGVDSLFEYL VKASVLLNRP ELLELFHEAR AAIDKYMRKE
310 320 330 340 350
DWYVWVGMNK GRVTLPVFQS LEAFWPGILS IIGDTEPALR TISRYIGVWK
360 370 380 390 400
KYGFLPEFYN IAAGEASPNR EVYPLRPELI ESAMYLYRAT GNEYLLEFGE
410 420 430 440 450
HMLETLEFSA KTKCGYATIR NVVTHEKENR MESFFLAETS KYLYLLFDEE
460 470 480 490 500
NFLHNDGSGG ELLSTEDDVC VVQAGAYIFN TEAHPMDMSA LHCCHAHNED
510 520 530 540 550
IYTSLDLQRF SPRAILERSK KRQVAVQEQW VPQCHPENNE FFNKEDESVQ
560 570 580 590 600
AQDSEKEQER EQSGTSTTMA VDIEVFDEFQ QPAGDLLVSN FEQIREEREL
610 620 630 640 650
NESLHRNVVA RNQLTVSDLD EFFAQRRESF ASASEALNYV KTFMGNYTMD
660 670 680 690 700
VAFIRGLQLY DTNMSSVLGT GAQKEYESRM RTLWQLYELQ QQYVANIRVI
710 720 730 740 750
QGLGLLTFPA DGDRIPSHLT EVLDSLDKSA HLEHMDLQDL ETRVSNTSSP
760 770 780 790 800
QLAHIREVIL KARNAYAIAM VNTSAMQEFA IRIYLSGTSE AGVRIHPLLE
810 820 830 840 850
DAELSEEARK RPLKLAEERA LFSYARRIVD FRKRMAETVD RLQTLMQDIP
860 870 880 890 900
PPKRKEATTD SQAADASTVY TQTKAQMAAP AQQPEPSQEE KQSTQIQKGK
910 920 930 940 950
LAENGSGLGE EESGCVWSQL VQTILRKTTV QRVKFDEAVL QENTRKALEK
960 970 980 990
YARKELPHHL FACTGRSTLR DSPIGTFIRK RCKLAITSPT NTTDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021086 Genomic DNA Translation: CAA15933.1 |
Genome annotation databases
UCSCi | CG3810-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021086 Genomic DNA Translation: CAA15933.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
CAZyi | GH47, Glycoside Hydrolase Family 47 |
Proteomic databases
PeptideAtlasi | O46091 |
Genome annotation databases
UCSCi | CG3810-RB, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0023511, Edem1 |
VEuPathDBi | VectorBase:FBgn0023511 |
Phylogenomic databases
HOGENOMi | CLU_003818_5_2_1 |
OMAi | NTTAMQE |
PhylomeDBi | O46091 |
Gene expression databases
Bgeei | FBgn0023511, Expressed in embryonic/larval hemocyte (Drosophila) and 34 other tissues |
ExpressionAtlasi | O46091, baseline and differential |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR044674, EDEM1/2/3 IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases |
PANTHERi | PTHR45679, PTHR45679, 1 hit |
Pfami | View protein in Pfam PF01532, Glyco_hydro_47, 1 hit |
PRINTSi | PR00747, GLYHDRLASE47 |
SUPFAMi | SSF48225, SSF48225, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | O46091_DROME | |
Accessioni | O46091Primary (citable) accession number: O46091 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | January 19, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |