UniProtKB - O46085 (O46085_DROME)
Protein
Submitted name:
GH08708p
Gene
Pex5
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- peroxisome matrix targeting signal-1 binding Source: GO_Central
GO - Biological processi
- peroxisome organization Source: FlyBase
- protein import into peroxisome matrix, docking Source: GO_Central
- response to anesthetic Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-DME-9033241, Peroxisomal protein import R-DME-9664873, Pexophagy |
Names & Taxonomyi
Protein namesi | Submitted name: GH08708pImportedSubmitted name: Peroxin 5, isoform AImported |
Gene namesi | Name:Pex5Imported Synonyms:armImported, Dmel\CG14815Imported, DmelPex5Imported, EG:63B12.5Imported, PEX5Imported ORF Names:CG14815Imported, Dmel_CG14815Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0023516, Pex5 |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: GO_Central
Peroxisome
- peroxisomal membrane Source: GO_Central
- peroxisome Source: FlyBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 30 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0023516, Expressed in crop (Drosophila) and 36 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | O46085, 21 interactors |
STRINGi | 7227.FBpp0070351 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 306 – 555 | TPR_REGIONInterPro annotationAdd BLAST | 250 | |
Repeati | 306 – 339 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 340 – 373 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 374 – 407 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 454 – 487 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 488 – 521 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 522 – 555 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the peroxisomal targeting signal receptor family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, TPR repeatPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG1125, Eukaryota |
GeneTreei | ENSGT00940000169247 |
OrthoDBi | 588648at2759 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR024111, PTS1R_family IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR10130, PTHR10130, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 4 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 6 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O46085-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQSGIWRSK PILWRIRFCA AIYFIIIRAL CNTVTKPIAS ITADKQLRSI
60 70 80 90 100
STSNTMSFRP LVEGDCGGVN PLMQLGGQFT RDVAHKDEGY VQRHFERAAR
110 120 130 140 150
PEDQLINEFL GQVTAPPQSF QMDTLLQEMR DINIHGNPQQ QMHSQQAEQW
160 170 180 190 200
GQDFARGLAP ALPNKMIHMQ AQQQDLQHAQ EFFDEPLISS QNFRSLPPLR
210 220 230 240 250
QPLMPIAAGQ QQDPFFDSAM ETIITDHLPQ APQGESLDDW ISDYQRSTEQ
260 270 280 290 300
KEQTAANFNE KFWERLQDEW QKLADENEHP WLSEYNDNMD AYKEYEFAEG
310 320 330 340 350
NPMSDVENPF EKGKEYLSKG DIPSAVLCFE VAAKKQPERA EVWQLLGTSQ
360 370 380 390 400
TENEMDPQAI AALKRAYDLQ PDNQQVLMAL AACYTNEGLQ NNAVRMLCNW
410 420 430 440 450
LTVHPKYQHL VAAHPELQAE GTSLASSLIG PSKLRDLQQI YLEAVRQHPS
460 470 480 490 500
EVDAEVQDAL GVLYNLSGEF DKAVDCYQSA LQVDPQNAKT WNRLGASLAN
510 520 530 540 550
GSRSVEAVEA YQQALQLQPG FIRVRYNVGV CCMNLKAYKE AVEHLLTALT
560 570 580 590 600
MQAHTNAARE LPNAAMAATF RGQNQMSESI WSTLKMVISL MGRSDLQSYV
610
SDRNLAALNE AFKD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7KW08 | Q7KW08_DROME | EG:63B12.5 protein | Pex5 Dmel\CG14815, DmelPex5, EG:63B12.5, PEX5, CG14815 | 559 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF45676.2 AY118757 mRNA Translation: AAM50617.1 |
PIRi | T12680 |
RefSeqi | NP_726771.1, NM_166910.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0070367; FBpp0070351; FBgn0023516 |
GeneIDi | 31141 |
UCSCi | CG14815-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF45676.2 AY118757 mRNA Translation: AAM50617.1 |
PIRi | T12680 |
RefSeqi | NP_726771.1, NM_166910.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O46085, 21 interactors |
STRINGi | 7227.FBpp0070351 |
Genome annotation databases
EnsemblMetazoai | FBtr0070367; FBpp0070351; FBgn0023516 |
GeneIDi | 31141 |
UCSCi | CG14815-RA, d. melanogaster |
Organism-specific databases
CTDi | 5830 |
FlyBasei | FBgn0023516, Pex5 |
Phylogenomic databases
eggNOGi | KOG1125, Eukaryota |
GeneTreei | ENSGT00940000169247 |
OrthoDBi | 588648at2759 |
Enzyme and pathway databases
Reactomei | R-DME-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-DME-9033241, Peroxisomal protein import R-DME-9664873, Pexophagy |
Miscellaneous databases
BioGRID-ORCSi | 31141, 1 hit in 3 CRISPR screens |
ChiTaRSi | arm, fly |
GenomeRNAii | 31141 |
Gene expression databases
Bgeei | FBgn0023516, Expressed in crop (Drosophila) and 36 other tissues |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR024111, PTS1R_family IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR10130, PTHR10130, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 4 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 6 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O46085_DROME | |
Accessioni | O46085Primary (citable) accession number: O46085 Secondary accession number(s): Q8MSJ5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 1998 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |