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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB
  • phosphoprotein phosphatase activity Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: FlyBase
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • peptidyl-threonine dephosphorylation Source: FlyBase
  • positive regulation of mitochondrial fission Source: FlyBase
  • protein dephosphorylation Source: UniProtKB
  • regulation of mitochondrion organization Source: FlyBase
  • response to anesthetic Source: FlyBase
  • response to heat Source: FlyBase

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-DME-8934903 Receptor Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
Short name:
DPGAM5
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene namesi
Name:Pgam5
ORF Names:CG14816
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023517 Pgam5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002887891 – 289Serine/threonine-protein phosphatase Pgam5, mitochondrialAdd BLAST289

Proteomic databases

PaxDbiO46084
PRIDEiO46084

Expressioni

Gene expression databases

BgeeiFBgn0023517
ExpressionAtlasiO46084 baseline and differential
GenevisibleiO46084 DM

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi57689, 26 interactors
DIPiDIP-18549N
IntActiO46084, 23 interactors
STRINGi7227.FBpp0070350

Structurei

3D structure databases

ProteinModelPortaliO46084
SMRiO46084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4609 Eukaryota
ENOG410XXCQ LUCA
GeneTreeiENSGT00390000004796
InParanoidiO46084
KOiK15637
OMAiHLTNRIP
OrthoDBiEOG091G0DEJ
PhylomeDBiO46084

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit

Sequencei

Sequence statusi: Complete.

O46084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLTSFVCG TGAGLAAYYL QRLRDPQTVV QNSWTHSDKP VDPWALWDTN
60 70 80 90 100
WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV
110 120 130 140 150
GDSDDTHHLT ERGRKQAEFT GKRLCELGIK WDKVVASTMV RAQETSDIIL
160 170 180 190 200
KQIDFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAGFR
210 220 230 240 250
RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRININHASI
260 270 280
TWLTISPSGN VSIKYLGDSG FMPAELLTNR IPRDVKNVV
Length:289
Mass (Da):33,166
Last modified:June 1, 1998 - v1
Checksum:i6DE63EE448170361
GO

Sequence cautioni

The sequence AAL28156 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45678.1
AL021106 Genomic DNA Translation: CAA15939.1
AY060608 mRNA Translation: AAL28156.2 Different initiation.
PIRiT12682
RefSeqiNP_569951.1, NM_130595.3

Genome annotation databases

EnsemblMetazoaiFBtr0070366; FBpp0070350; FBgn0023517
GeneIDi31143
KEGGidme:Dmel_CG14816
UCSCiCG14816-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPGAM5_DROME
AccessioniPrimary (citable) accession number: O46084
Secondary accession number(s): Q7K2X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 1998
Last modified: July 18, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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