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Protein

Poly(ADP-ribose) glycohydrolase

Gene

Parg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D-ribose. EC:3.2.1.143

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • poly(ADP-ribose) glycohydrolase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-DME-110362 POLB-Dependent Long Patch Base Excision Repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly(ADP-ribose) glycohydrolase (EC:3.2.1.143)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Parg
ORF Names:CG2864
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0023216 Parg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Progressive neurodegeneration.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000666071 – 723Poly(ADP-ribose) glycohydrolaseAdd BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei579Phosphoserine1 Publication1
Modified residuei582Phosphoserine1 Publication1
Modified residuei583Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O46043

PRoteomics IDEntifications database

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PRIDEi
O46043

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O46043

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0023216 Expressed in 29 organ(s), highest expression level in egg chamber

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O46043 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
57851, 4 interactors

Protein interaction database and analysis system

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IntActi
O46043, 1 interactor

STRING: functional protein association networks

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STRINGi
7227.FBpp0298281

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O46043

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O46043

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2064 Eukaryota
ENOG410XT3Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003652

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O46043

KEGG Orthology (KO)

More...
KOi
K07759

Identification of Orthologs from Complete Genome Data

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OMAi
HVRLPCA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01FM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O46043

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007724 Poly_GlycHdrlase

The PANTHER Classification System

More...
PANTHERi
PTHR12837 PTHR12837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05028 PARG_cat, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O46043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSPDGGIS EIETEEEPEN LANSLDDSWR GVSMEAIHRN RQPFELENLP
60 70 80 90 100
PVTAGNLHRV MYQLPIRETP PRPYKSPGKW DSEHVRLPCA PESKYPRENP
110 120 130 140 150
DGSTTIDFRW EMIERALLQP IKTCEELQAA IISYNTTYRD QWHFRALHQL
160 170 180 190 200
LDEELDESET RVFFEDLLPR IIRLALRLPD LIQSPVPLLK HHKNASLSLS
210 220 230 240 250
QQQISCLLAN AFLCTFPRRN TLKRKSEYST FPDINFNRLY QSTGPAVLEK
260 270 280 290 300
LKCIMHYFRR VCPTERDASN VPTGVVTFVR RSGLPEHLID WSQSAAPLGD
310 320 330 340 350
VPLHVDAEGT IEDEGIGLLQ VDFANKYLGG GVLGHGCVQE EIRFVICPEL
360 370 380 390 400
LVGKLFTECL RPFEALVMLG AERYSNYTGY AGSFEWSGNF EDSTPRDSSG
410 420 430 440 450
RRQTAIVAID ALHFAQSHHQ YREDLMEREL NKAYIGFVHW MVTPPPGVAT
460 470 480 490 500
GNWGCGAFGG DSYLKALLQL MVCAQLGRPL AYYTFGNVEF RDDFHEMWLL
510 520 530 540 550
FRNDGTTVQQ LWSILRSYSR LIKEKSSKEP RENKASKKKL YDFIKEELKK
560 570 580 590 600
VRDVPGEGAS AEAGSSRVAG LGEGKSETSA KSSPELNKQP ARPQITITQQ
610 620 630 640 650
STDLLPAQLS QDNSNSSEDQ ALLMLSDDEE ANAMMEAASL EAKSSVEISN
660 670 680 690 700
SSTTSKTSST ATKSMGSGGR QLSLLEMLDT HYEKGSASKR PRKSPNCSKA
710 720
EGSAKSRKEI DVTDKDEKDD IVD
Length:723
Mass (Da):81,109
Last modified:April 16, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90A5BA59775D611C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC28734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF079556 mRNA Translation: AAC28734.1 Different initiation.
AE014298 Genomic DNA Translation: AAF45886.2
AE014298 Genomic DNA Translation: AFH07225.1
Z98254 Genomic DNA Translation: CAB10913.1
AY051955 mRNA Translation: AAK93379.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245511.1, NM_001258582.2
NP_477321.2, NM_057973.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.2967

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0307279; FBpp0298280; FBgn0023216
FBtr0307280; FBpp0298281; FBgn0023216

Database of genes from NCBI RefSeq genomes

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GeneIDi
31329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2864

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079556 mRNA Translation: AAC28734.1 Different initiation.
AE014298 Genomic DNA Translation: AAF45886.2
AE014298 Genomic DNA Translation: AFH07225.1
Z98254 Genomic DNA Translation: CAB10913.1
AY051955 mRNA Translation: AAK93379.1
RefSeqiNP_001245511.1, NM_001258582.2
NP_477321.2, NM_057973.4
UniGeneiDm.2967

3D structure databases

ProteinModelPortaliO46043
SMRiO46043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57851, 4 interactors
IntActiO46043, 1 interactor
STRINGi7227.FBpp0298281

PTM databases

iPTMnetiO46043

Proteomic databases

PaxDbiO46043
PRIDEiO46043

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0307279; FBpp0298280; FBgn0023216
FBtr0307280; FBpp0298281; FBgn0023216
GeneIDi31329
KEGGidme:Dmel_CG2864

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8505
FlyBaseiFBgn0023216 Parg

Phylogenomic databases

eggNOGiKOG2064 Eukaryota
ENOG410XT3Y LUCA
GeneTreeiENSGT00390000003652
InParanoidiO46043
KOiK07759
OMAiHVRLPCA
OrthoDBiEOG091G01FM
PhylomeDBiO46043

Enzyme and pathway databases

ReactomeiR-DME-110362 POLB-Dependent Long Patch Base Excision Repair

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31329

Protein Ontology

More...
PROi
PR:O46043

Gene expression databases

BgeeiFBgn0023216 Expressed in 29 organ(s), highest expression level in egg chamber
GenevisibleiO46043 DM

Family and domain databases

InterProiView protein in InterPro
IPR007724 Poly_GlycHdrlase
PANTHERiPTHR12837 PTHR12837, 1 hit
PfamiView protein in Pfam
PF05028 PARG_cat, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARG_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O46043
Secondary accession number(s): M9NEU9, Q960N8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: April 16, 2014
Last modified: December 5, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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