The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - O45946 (RL18_CAEEL)
Protein
60S ribosomal protein L18
Gene
rpl-18
Organism
Caenorhabditis elegans
Status
Functioni
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- translation Source: InterPro
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-CEL-1799339, SRP-dependent cotranslational protein targeting to membrane R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-CEL-72689, Formation of a pool of free 40S subunits R-CEL-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-CEL-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-CEL-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L18 |
Gene namesi | Name:rpl-18 ORF Names:Y45F10D.12 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | Y45F10D.12 ; CE16650 ; WBGene00004430 ; rpl-18 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosolic large ribosomal subunit Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291623 | 1 – 188 | 60S ribosomal protein L18Add BLAST | 188 |
Proteomic databases
EPDi | O45946 |
PaxDbi | O45946 |
PeptideAtlasi | O45946 |
Expressioni
Gene expression databases
Bgeei | WBGene00004430, Expressed in germ line (C elegans) and 5 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 43426, 91 interactors |
DIPi | DIP-25467N |
STRINGi | 6239.Y45F10D.12.3 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 188 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 165 – 188 | Basic residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL18 family.Curated
Phylogenomic databases
eggNOGi | KOG1714, Eukaryota |
GeneTreei | ENSGT00390000012976 |
HOGENOMi | CLU_080024_0_0_1 |
InParanoidi | O45946 |
OMAi | MSKIHRP |
OrthoDBi | 1303996at2759 |
PhylomeDBi | O45946 |
Family and domain databases
InterProi | View protein in InterPro IPR036227, L18e/L15P_sf IPR000039, Ribosomal_L18e IPR021131, Ribosomal_L18e/L15P |
PANTHERi | PTHR10934, PTHR10934, 1 hit |
Pfami | View protein in Pfam PF17135, Ribosomal_L18, 1 hit |
SUPFAMi | SSF52080, SSF52080, 1 hit |
i Sequence
Sequence statusi: Complete.
O45946-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIDINHKHD RVARRTAPKS ENPYLRLLSK LYAFLARRTG EKFNAIVLKR
60 70 80 90 100
LRMSRRNRQP LSLAKLARAV QKAGNENKTV VTLSTVTDDA RLYTVPKISV
110 120 130 140 150
AALHVTEGAR ARILAAGGEI ITLDQLALKS PKGENTVFLQ GPRSAREAEK
160 170 180
HFGPAPGVPH SHTKPYVRSK GRKFERARGR RASRAYKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021492 Genomic DNA Translation: CAA16387.1 |
PIRi | T26939 |
RefSeqi | NP_502655.1, NM_070254.4 |
Genome annotation databases
EnsemblMetazoai | Y45F10D.12.1; Y45F10D.12.1; WBGene00004430 Y45F10D.12.2; Y45F10D.12.2; WBGene00004430 |
GeneIDi | 178342 |
KEGGi | cel:CELE_Y45F10D.12 |
UCSCi | Y45F10D.12.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021492 Genomic DNA Translation: CAA16387.1 |
PIRi | T26939 |
RefSeqi | NP_502655.1, NM_070254.4 |
3D structure databases
AlphaFoldDBi | O45946 |
SMRi | O45946 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 43426, 91 interactors |
DIPi | DIP-25467N |
STRINGi | 6239.Y45F10D.12.3 |
Proteomic databases
EPDi | O45946 |
PaxDbi | O45946 |
PeptideAtlasi | O45946 |
Genome annotation databases
EnsemblMetazoai | Y45F10D.12.1; Y45F10D.12.1; WBGene00004430 Y45F10D.12.2; Y45F10D.12.2; WBGene00004430 |
GeneIDi | 178342 |
KEGGi | cel:CELE_Y45F10D.12 |
UCSCi | Y45F10D.12.1, c. elegans |
Organism-specific databases
CTDi | 178342 |
WormBasei | Y45F10D.12 ; CE16650 ; WBGene00004430 ; rpl-18 |
Phylogenomic databases
eggNOGi | KOG1714, Eukaryota |
GeneTreei | ENSGT00390000012976 |
HOGENOMi | CLU_080024_0_0_1 |
InParanoidi | O45946 |
OMAi | MSKIHRP |
OrthoDBi | 1303996at2759 |
PhylomeDBi | O45946 |
Enzyme and pathway databases
Reactomei | R-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-CEL-1799339, SRP-dependent cotranslational protein targeting to membrane R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-CEL-72689, Formation of a pool of free 40S subunits R-CEL-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-CEL-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-CEL-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
PROi | PR:O45946 |
Gene expression databases
Bgeei | WBGene00004430, Expressed in germ line (C elegans) and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036227, L18e/L15P_sf IPR000039, Ribosomal_L18e IPR021131, Ribosomal_L18e/L15P |
PANTHERi | PTHR10934, PTHR10934, 1 hit |
Pfami | View protein in Pfam PF17135, Ribosomal_L18, 1 hit |
SUPFAMi | SSF52080, SSF52080, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL18_CAEEL | |
Accessioni | O45946Primary (citable) accession number: O45946 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families