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Entry version 133 (07 Apr 2021)
Sequence version 1 (01 Jun 1998)
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Protein
Submitted name:

NEPrilysin metallopeptidase family

Gene

nep-17

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseARBA annotation, Protease
LigandMetal-bindingARBA annotation, ZincARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2022377, Metabolism of Angiotensinogen to Angiotensins
R-CEL-6798695, Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M13.A20

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NEPrilysin metallopeptidase familyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nep-17Imported
ORF Names:CELE_F54F11.2Imported, F54F11.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F54F11.2a ; CE11095 ; WBGene00010070 ; nep-17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O45569

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O45569

PeptideAtlas

More...
PeptideAtlasi
O45569

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00010070, Expressed in multi-cellular organism and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O45569, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F54F11.2a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 558Peptidase_M13_NInterPro annotationAdd BLAST445
Domaini619 – 831Peptidase_M13InterPro annotationAdd BLAST213
Domaini886 – 1308Peptidase_M13_NInterPro annotationAdd BLAST423
Domaini1369 – 1582Peptidase_M13InterPro annotationAdd BLAST214

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M13 family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3624, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O45569

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSFAQVW

Database of Orthologous Groups

More...
OrthoDBi
282463at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08662, M13, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1380.10, 2 hits
3.40.390.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024079, MetalloPept_cat_dom_sf
IPR000718, Peptidase_M13
IPR018497, Peptidase_M13_C
IPR042089, Peptidase_M13_dom_2
IPR008753, Peptidase_M13_N

The PANTHER Classification System

More...
PANTHERi
PTHR11733, PTHR11733, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01431, Peptidase_M13, 2 hits
PF05649, Peptidase_M13_N, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00786, NEPRILYSIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51885, NEPRILYSIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O45569-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPGSGNIV HTLLLVAGIV LTAGVLGVVI AILVNENNTN TNTNTIYNGT
60 70 80 90 100
NTYNSTIQYN STYVYNSTII EIDIASKVLN VAQPAKVSPG TDKYNSYQQV
110 120 130 140 150
VQLFKASVNL SVDPCNDFYA YTCGNFKGDM SFDISDNSNT NDMVTRLTND
160 170 180 190 200
TYISTAPLPV QQTRWYFDTC VNARQNWNTI ADGSVVTAAI NQLAAGNPGK
210 220 230 240 250
HENSTKFPFP MLDQKTDVTT FPDRFGLGYL TGSLTAQGVD TIISAGVDTN
260 270 280 290 300
WKDPAGPEGF AYLIDQPTTF APNTYYLKDF DALNASLTYQ ITENMLQLAK
310 320 330 340 350
VQNKTLDANI LAKDVQDIIK LDYLLATKFS TDDTTRRQYD RSYNPNTLPQ
360 370 380 390 400
LLTQYHKDVF SWHMFLPIAV GTAEHVLDKL LDQGSGYNYY ITMEPTKLNM
410 420 430 440 450
LLTSLNKDNT LGITPRALVN YFYYRLVDSL SEFLPAPPAG NMIRPFVKIE
460 470 480 490 500
RQPVGRPRHV LPEDRKYERK LIEDLTEAQY SCAQETIDIQ YANARLFIDQ
510 520 530 540 550
IYPTATDRKN VREHVAKVAS SIVIGFRSMI DQLNWMTPST KKGAYNKIEN
560 570 580 590 600
LVKNIAYPDW ITDDAQLTAY HAPMNFTKTD TYVDMFFNVQ NFNLYSQWDQ
610 620 630 640 650
LVQGPADRTG FNGPPGITNA WYQPELNSIT FPAGILKKPF YDFNWPASVN
660 670 680 690 700
FGAMGVIAGH ELTHGFDDQG VQWNGVGTLS GWMDATSKVS FTNMAQCVVN
710 720 730 740 750
EYSGFCPLDK ATYGSAACID GAQTQGENIA DNGGIHSAFR AYKNYVDLYG
760 770 780 790 800
PDPVLPDPQL QYFNPDQLFF LSFAQVWCQM PYTDAQFLRQ ILVDVHSPSI
810 820 830 840 850
YRVLGTIQNF PAFKTAFNCP SSTYAPDNHC NVWVSDIDTT FGLPNVKTDI
860 870 880 890 900
NVVPEAPITS TNVDKMNAYQ MAVDYYAKSV NTAIDPCDDF YSYACGNFNQ
910 920 930 940 950
SVSFYTARAQ NLVYMAQKLE DPTYQTTINS SPALKKEKQL YNACLTATAS
960 970 980 990 1000
SQSEDQILIS KNYIQTKVDD LKTLIGQDFT LVNGGAPKLP SAKQIGDALG
1010 1020 1030 1040 1050
YLSFEQGIDT LISPLVDTYW IDNSKGYQMF IDQNTAYLSK TYYQPAAWKI
1060 1070 1080 1090 1100
EKPKYLKMAL DVVTRYAREQ NITLPAGASD LLSNVLDYEQ NIAVKYSTDD
1110 1120 1130 1140 1150
NTRRQFQRSW NLTKTSDLVT KYNFMDWMTY LSHAPNAVKA KITDANYQVS
1160 1170 1180 1190 1200
VMEVDRLTHF SADYLQQSPE LLVNLLFVRL LLGNAQYIPS YASAFRGMTD
1210 1220 1230 1240 1250
ESIFLGLSRR KTIPNHIPPP NFDLEANGPA CASVANNLMQ FANGRVFVDY
1260 1270 1280 1290 1300
MYPTAQDVTN IRKSAGGIIK NVISSFQGMI DQLDWMAPDT KQKAYAKTVQ
1310 1320 1330 1340 1350
IQQNIAFPDW IKNDTLLGNY YSTLVIADSD NFYDIYDKLI KFNIFVQYNQ
1360 1370 1380 1390 1400
LNAAQTDRTD FLGQPGTVNA WYQPELNSIT FPAGILVPPY FNPNWPPSIN
1410 1420 1430 1440 1450
YGGMGLVAGH ELTHGFDDQG VQWGPTGNLA RWMDDNSMAG FKNMSQCVIN
1460 1470 1480 1490 1500
EYSGFCPLNA TNYSPNCVKG PQTQGENIAD NGGVHAAFNA YKTHQSLDGP
1510 1520 1530 1540 1550
DPRLPDRLFG QFTHDQLFFM SFAQVWCEVR RTDDALYTQI MVDPHSPSMY
1560 1570 1580
RVYGTIQNFP AFQTAFNCPL GSKSAPEQHC EVWVPGKYQ
Length:1,589
Mass (Da):178,049
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2A1A57168287291
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B6VQ96B6VQ96_CAEEL
NEPrilysin metallopeptidase family
nep-17 CELE_F54F11.2, F54F11.2
1,460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAB05739.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T22668

NCBI Reference Sequences

More...
RefSeqi
NP_001254395.1, NM_001267466.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F54F11.2a.1; F54F11.2a.1; WBGene00010070

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F54F11.2

UCSC genome browser

More...
UCSCi
F54F11.2, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAB05739.1
PIRiT22668
RefSeqiNP_001254395.1, NM_001267466.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F54F11.2a

Protein family/group databases

MEROPSiM13.A20

Proteomic databases

EPDiO45569
PaxDbiO45569
PeptideAtlasiO45569

Genome annotation databases

EnsemblMetazoaiF54F11.2a.1; F54F11.2a.1; WBGene00010070
GeneIDi174996
KEGGicel:CELE_F54F11.2
UCSCiF54F11.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174996
WormBaseiF54F11.2a ; CE11095 ; WBGene00010070 ; nep-17

Phylogenomic databases

eggNOGiKOG3624, Eukaryota
InParanoidiO45569
OMAiMSFAQVW
OrthoDBi282463at2759

Enzyme and pathway databases

ReactomeiR-CEL-2022377, Metabolism of Angiotensinogen to Angiotensins
R-CEL-6798695, Neutrophil degranulation

Gene expression databases

BgeeiWBGene00010070, Expressed in multi-cellular organism and 4 other tissues
ExpressionAtlasiO45569, baseline and differential

Family and domain databases

CDDicd08662, M13, 2 hits
Gene3Di1.10.1380.10, 2 hits
3.40.390.10, 2 hits
InterProiView protein in InterPro
IPR024079, MetalloPept_cat_dom_sf
IPR000718, Peptidase_M13
IPR018497, Peptidase_M13_C
IPR042089, Peptidase_M13_dom_2
IPR008753, Peptidase_M13_N
PANTHERiPTHR11733, PTHR11733, 4 hits
PfamiView protein in Pfam
PF01431, Peptidase_M13, 2 hits
PF05649, Peptidase_M13_N, 2 hits
PRINTSiPR00786, NEPRILYSIN
PROSITEiView protein in PROSITE
PS51885, NEPRILYSIN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO45569_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O45569
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 7, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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