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UniProtKB - O45218 (ADAS_CAEEL)
Protein
Alkyldihydroxyacetonephosphate synthase
Gene
ads-1
Organism
Caenorhabditis elegans
Status
Functioni
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
By similarityCatalytic activityi
- a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H+EC:2.5.1.26
Cofactori
FADBy similarity
: ether lipid biosynthesis Pathwayi
This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 348 | Important for enzyme activityBy similarity | 1 | |
Binding sitei | 444 | SubstrateBy similarity | 1 | |
Active sitei | 507 | Proton donor/acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 163 – 169 | FADBy similarity | 7 | |
Nucleotide bindingi | 232 – 238 | FADBy similarity | 7 | |
Nucleotide bindingi | 245 – 248 | FADBy similarity | 4 | |
Nucleotide bindingi | 297 – 303 | FADBy similarity | 7 |
GO - Molecular functioni
- alkylglycerone-phosphate synthase activity Source: UniProtKB
- FAD binding Source: UniProtKB
- oxidoreductase activity Source: InterPro
GO - Biological processi
- ether lipid biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
Reactomei | R-CEL-75896, Plasmalogen biosynthesis |
UniPathwayi | UPA00781 |
Names & Taxonomyi
Protein namesi | Recommended name: Alkyldihydroxyacetonephosphate synthase (EC:2.5.1.26)Short name: Alkyl-DHAP synthase Alternative name(s): Alkylglycerone-phosphate synthase |
Gene namesi | Name:ads-1 ORF Names:Y50D7A.7 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | Y50D7A.7 ; CE26144 ; WBGene00000081 ; ads-1 |
Subcellular locationi
Peroxisome
Peroxisome
- peroxisome Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128177 | 1 – 597 | Alkyldihydroxyacetonephosphate synthaseAdd BLAST | 597 |
Proteomic databases
EPDi | O45218 |
PaxDbi | O45218 |
PeptideAtlasi | O45218 |
Expressioni
Gene expression databases
Bgeei | WBGene00000081, Expressed in material anatomical entity and 4 other tissues |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 40467, 2 interactors |
STRINGi | 6239.Y50D7A.7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 131 – 313 | FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 544 – 546 | Important for enzyme activityBy similarity | 3 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 595 – 597 | Microbody targeting signalSequence analysis | 3 |
Sequence similaritiesi
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.Curated
Phylogenomic databases
eggNOGi | KOG1233, Eukaryota |
GeneTreei | ENSGT00940000156112 |
HOGENOMi | CLU_017779_2_2_1 |
InParanoidi | O45218 |
OMAi | PRCHDEV |
OrthoDBi | 824020at2759 |
PhylomeDBi | O45218 |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR025650, Alkyl-DHAP_Synthase IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
PANTHERi | PTHR46568, PTHR46568, 1 hit |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
i Sequence
Sequence statusi: Complete.
O45218-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSASYQTIEH DVPQSYRDKI LKWNGWGYSD SQFAINKDGH VTFTGDKYEI
60 70 80 90 100
SGKVMPHFRP WFENYLGIDL GFVSPAQKLS DVIIDAPVEN EDIIEFLQEN
110 120 130 140 150
KISFSNEARI RLMRGHGHTV HDMINLREGK IPRLPDIVVW PKSEHEIVKI
160 170 180 190 200
IEGAMSHNCA IIPIGGGTSV TNALDTPETE KRAVISMDMA LLDKILWIDR
210 220 230 240 250
ENLTCRAQAG IVGQSLERQL NKKGFTCGHE PDSIEFSTLG GWVSTRASGM
260 270 280 290 300
KKNKYGNIED LVVHLNFVCP KGIIQKQCQV PRMSSGPDIH QIILGSEGTL
310 320 330 340 350
GVVSEVTIKI FPIPEVKRFG SFVFPNFESG VNFFREVAIQ RCQPASLRLM
360 370 380 390 400
DNDQFVMGQA LKVASDSWWA DLKSSVSKMY ITSWKGFKVD EICAATCVYE
410 420 430 440 450
GNREEVDQHE ERLNKLAEQF HGVVGGAENG QYGYRLTFAI AYLRDLGMNH
460 470 480 490 500
GVLGESFETS VPWDKVLSLC RNVKELMKRE AKAQGVTHPV LANCRVTQVY
510 520 530 540 550
DAGACVYFYF GFNARGLKNG LEVYDRIETA ARDEIIACGG SISHHHGVGK
560 570 580 590
IRKQWMLTTN GAVGIALLKA IKSELDPANI FASANLIDII GSPHCKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002686 mRNA Translation: CAA05690.1 FO081772 Genomic DNA Translation: CCD73794.1 |
PIRi | JC5829 |
RefSeqi | NP_497185.1, NM_064784.7 |
Genome annotation databases
EnsemblMetazoai | Y50D7A.7.1; Y50D7A.7.1; WBGene00000081 |
GeneIDi | 175192 |
KEGGi | cel:CELE_Y50D7A.7 |
UCSCi | Y50D7A.7.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002686 mRNA Translation: CAA05690.1 FO081772 Genomic DNA Translation: CCD73794.1 |
PIRi | JC5829 |
RefSeqi | NP_497185.1, NM_064784.7 |
3D structure databases
SMRi | O45218 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 40467, 2 interactors |
STRINGi | 6239.Y50D7A.7 |
Proteomic databases
EPDi | O45218 |
PaxDbi | O45218 |
PeptideAtlasi | O45218 |
Genome annotation databases
EnsemblMetazoai | Y50D7A.7.1; Y50D7A.7.1; WBGene00000081 |
GeneIDi | 175192 |
KEGGi | cel:CELE_Y50D7A.7 |
UCSCi | Y50D7A.7.1, c. elegans |
Organism-specific databases
CTDi | 175192 |
WormBasei | Y50D7A.7 ; CE26144 ; WBGene00000081 ; ads-1 |
Phylogenomic databases
eggNOGi | KOG1233, Eukaryota |
GeneTreei | ENSGT00940000156112 |
HOGENOMi | CLU_017779_2_2_1 |
InParanoidi | O45218 |
OMAi | PRCHDEV |
OrthoDBi | 824020at2759 |
PhylomeDBi | O45218 |
Enzyme and pathway databases
UniPathwayi | UPA00781 |
Reactomei | R-CEL-75896, Plasmalogen biosynthesis |
Miscellaneous databases
PROi | PR:O45218 |
Gene expression databases
Bgeei | WBGene00000081, Expressed in material anatomical entity and 4 other tissues |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR025650, Alkyl-DHAP_Synthase IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
PANTHERi | PTHR46568, PTHR46568, 1 hit |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAS_CAEEL | |
Accessioni | O45218Primary (citable) accession number: O45218 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | September 29, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families