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Protein
Submitted name:

SUPpressor

Gene

sup-12

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • pre-mRNA binding Source: WormBase
  • pre-mRNA intronic binding Source: WormBase
  • single-stranded RNA binding Source: WormBase

GO - Biological processi

  • alternative mRNA splicing, via spliceosome Source: WormBase
  • regulation of actin cytoskeleton organization Source: WormBase
  • regulation of alternative mRNA splicing, via spliceosome Source: WormBase
  • regulation of locomotion Source: WormBase

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
SUPpressorImported
Gene namesi
Name:sup-12Imported
ORF Names:CELE_T22B2.4Imported, T22B2.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT22B2.4a ; CE13934 ; WBGene00006321 ; sup-12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiO45189
PaxDbiO45189

Expressioni

Gene expression databases

BgeeiWBGene00006321 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)
ExpressionAtlasiO45189 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
asd-1G5EEW73EBI-312079,EBI-312085

Protein-protein interaction databases

DIPiDIP-24970N
IntActiO45189, 5 interactors
STRINGi6239.T22B2.4a

Structurei

3D structure databases

ProteinModelPortaliO45189
SMRiO45189
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 112RRMInterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG0149 Eukaryota
ENOG4111PGT LUCA
GeneTreeiENSGT00390000002308
HOGENOMiHOG000276232
InParanoidiO45189
OMAiTDRNTQK
OrthoDBiEOG091G13K0
PhylomeDBiO45189

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O45189-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGQVQDPLV HAAAAALAQS TNAEPVVGSR DTMFTKIFVG GLPYHTSDKT
60 70 80 90 100
LHEYFEQFGD IEEAVVITDR NTQKSRGYGF VTMKDRASAE RACKDPNPII
110 120 130 140 150
DGRKANVNLA YLGAKPRTNV QLAALAAGQV QLPLTTQLQA LFQPRMGLPQ
160 170 180 190 200
MYYPTVTGLV NPLMAQQGAA AQQQLFDYNA LAAVMNPQAA AAYGIQSQGK
210 220 230 240
FAAAPTTIEQ YAAYPAGYGL VPQSAYNIGN PQLQQLAAAQ QQLEHQRV
Length:248
Mass (Da):26,775
Last modified:June 1, 1998 - v1
Checksum:i93EB1C8B7EBF25F4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2L051H2L051_CAEEL
SUPpressor
sup-12 CELE_T22B2.4, T22B2.4
151Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD71425.1
PIRiT33034
RefSeqiNP_508674.1, NM_076273.4
UniGeneiCel.4999

Genome annotation databases

EnsemblMetazoaiT22B2.4a; T22B2.4a; WBGene00006321
GeneIDi180674
KEGGicel:CELE_T22B2.4
UCSCiT22B2.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO45189_CAEEL
AccessioniPrimary (citable) accession number: O45189
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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