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Entry version 178 (07 Apr 2021)
Sequence version 2 (11 Jul 2006)
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Protein

Death-associated protein kinase dapk-1

Gene

dapk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of epidermal barrier repair and innate immune responses to wounding (PubMed:19164535, PubMed:27661253).

The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1 (PubMed:27661253).

In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA (PubMed:28087624).

Appears to act downstream of or in parallel to muscarinic signaling in the regulation of autophagy (PubMed:17785524).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei57ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei155Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processImmunity, Innate immunity
LigandATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O44997

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Death-associated protein kinase dapk-1 (EC:2.7.11.1By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dapk-1Imported
Synonyms:mor-3, tag-119
ORF Names:K12C11.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
K12C11.4 ; CE40262 ; WBGene00003400 ; dapk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Beginning in the L3 stage, animals display striking and progressive defects in morphology of the epidermis and cuticle in several body regions, particularly in the nose, tail, vulva, and the dorsal midline in the region of the posterior pharyngeal bulb (PubMed:19164535, PubMed:27661253). The cuticle in these regions becomes up to 5-10 times thicker than the wild-type, at the expense of underlying epidermis (PubMed:19164535, PubMed:27661253). Up-regulates innate immune responses to damage (PubMed:19164535). Decreases starvation-induced autophagy (PubMed:17785524). Disorganization and hyper-stabilization of epidermal microtubules and reduced microtubule growth rates (PubMed:27661253). Treatment with a microtubule stabilizing drug, paclitaxel, results in enhanced epidermal morphology defects (PubMed:27661253). In a ptrn-1 mutant background, suppression of the epidermal morphology defects (PubMed:27661253).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi57K → A: Normal localization and movement along microtubules and no exhibition of epidermal morphology defects. 1 Publication1
Mutagenesisi179S → L in ju4; Causes severe epidermal morphology defects, including progressive accumulation of the cuticle and degeneration of the underlying epidermis, accelerated wound closure, and disorganization and hyper-stabilization of epidermal microtubules. Reduces microtubule growth rates. Increased ptrn-1 filaments in the anterior lateral epidermis. In L4 larvae and in adults, disrupts expression of specific unc-44 mRNAs in L4 seam cells and in head and tail epidermal cells. Reduces nuclear localization of pinn-1 in epidermal cells. Increases expression of antimicrobial peptides. Epidermal defects are suppressed in an unc-44 or ptrn-1 mutant background. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004000891 – 1425Death-associated protein kinase dapk-1Add BLAST1425

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O44997

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O44997

PeptideAtlas

More...
PeptideAtlasi
O44997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epidermis, muscles and neurons.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present from late embryogenesis onwards.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003400, Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O44997, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ptrn-1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
52023, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.K12C11.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O44997

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST262
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati392 – 421ANK 1Sequence analysisAdd BLAST30
Repeati425 – 454ANK 2Sequence analysisAdd BLAST30
Repeati458 – 487ANK 3Sequence analysisAdd BLAST30
Repeati491 – 520ANK 4Sequence analysisAdd BLAST30
Repeati524 – 553ANK 5Sequence analysisAdd BLAST30
Repeati557 – 586ANK 6Sequence analysisAdd BLAST30
Repeati590 – 619ANK 7Sequence analysisAdd BLAST30
Repeati623 – 652ANK 8Sequence analysisAdd BLAST30
Domaini695 – 950RocPROSITE-ProRule annotationAdd BLAST256
Repeati810 – 841ANK 9Sequence analysisAdd BLAST32
Repeati934 – 963ANK 10Sequence analysisAdd BLAST30
Domaini1308 – 1389DeathPROSITE-ProRule annotationAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002849_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O44997

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRKMNGP

Database of Orthologous Groups

More...
OrthoDBi
67579at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O44997

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR011009, Kinase-like_dom_sf
IPR027417, P-loop_NTPase
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR020859, ROC_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF00531, Death, 1 hit
PF00069, Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 9 hits
SM00005, DEATH, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 7 hits
PS50017, DEATH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS51424, ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O44997-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDVNSSAT STSSSTVHFD DTPFEDVYEI ETELGSGQFA VVRRVRDRKT
60 70 80 90 100
GEKYAAKFIK KRRYATSRRG VTRQNIEREV RVLQKIRGNS NVVELHAVYE
110 120 130 140 150
TASDVIIVLE LVSGGELFDH VCAKECLDEV EAAAFIKQIL LAVRHLHSLH
160 170 180 190 200
IVHLDIKPEN VMLKQRGDSQ IKIIDFGLSR EIEPGAVVKD MVGTPEFVAP
210 220 230 240 250
EVVNYEALSP ATDMWAVGVV TYILLSGGSP FLGDNRDETF SNITRVRYHF
260 270 280 290 300
SDRYFKNTSK HAKDFIYRLF VRDVDQRATV EECLQHPWIR GPEGNAIDIR
310 320 330 340 350
KASCITISHI QSFKTRQRWK RCVELVMVLL KASKSSRRIG DGRFDEEDMV
360 370 380 390 400
ASCTLICAEE GNLRALHKLS ALHKLLPNAT RKSLKSSFSE PNGATAMHCA
410 420 430 440 450
AKYGHAEVFN YFHMKGGNIC ARDDNGDTPL HVACRFAQHT VAGYVANEKI
460 470 480 490 500
DVDSINKTGE TALHCAVESA DTRVVRLLLQ LRPRLDLPNA SGDTVLHLAA
510 520 530 540 550
DSINPRIVPL LVCLAPPLHL RNIREETPLH VAAARGHVDC VQALLDANSP
560 570 580 590 600
IDAVEQDGKT ALIIALENGN VDIASILITN GCDINHADHH GDTALHIASK
610 620 630 640 650
HGLLQAVQTL CHCAVTVDSV NANKKTALHL AAHYGHVDII RVLLLARADV
660 670 680 690 700
TLRGDDGLTA ELVAVAAERL EAHSLLKMVK SQEIREEYIS QLYPLDTSLR
710 720 730 740 750
RIKLKLLGHS QSGKTRLVQT LHSSRGISSF LESVTRRISD HYSPSSSMKD
760 770 780 790 800
DGIHSTNGSF VSESNNNSSF DLAAAAGSKY APPHSQYTRG IDVQTVNING
810 820 830 840 850
CGEFSVWEFG GYEPMHTCYD HFVGNADCIH LILYRTSDPT EVQYKQILYW
860 870 880 890 900
MNFLKGRVTP FEPIGHCGFS SRRSKVIIVG THATSSLFPQ MNQEGEYVSS
910 920 930 940 950
DIEAMLNTVR LRFETHFDMD HRLILLDATN PSCIGMKTLK MELAKCRTNI
960 970 980 990 1000
LAKLLKPLAI LDTVVNHLNL VRKKHANFPV ITWPDFIQLV RNEINPLTGD
1010 1020 1030 1040 1050
AHCRQIVQQL QLIGELVYLR NDLCDADYVV LNAEWFGTHI LGQLLSAEFL
1060 1070 1080 1090 1100
SKASPNGSYH TSSLAKIFPE IPEQSDLMTI LEVLQLCAPD ARTGAHEFPV
1110 1120 1130 1140 1150
FIQTEAPDSI WRPYSLKEKE RDTVYGGVRI LPMRGMERSL HSTFPRIQVA
1160 1170 1180 1190 1200
LRRSINDYQP AKDTQLHQWS ECSKLVSQDR EAVIRMVGDA VEIRARGPSE
1210 1220 1230 1240 1250
SATSMFYFME DLINLVEHAA AEVGPGISLE RHFISPKHLK EHREHPALFP
1260 1270 1280 1290 1300
PESMMEMQQR ESLSVKGTQD EEELFTDVVC FGSRDVARHL TLGIDVGVAD
1310 1320 1330 1340 1350
LQMASRCELA CLLDPPHAMG RDWSILAVKL QLTDQVPDVD STGQSLSRTD
1360 1370 1380 1390 1400
QLLNEWAIHH PEQASVGNLC RILVELGRCD ARDALYRTVP LYVFAPLEDQ
1410 1420
FLLETNDSGV VSSCHSSSEH NPINI
Length:1,425
Mass (Da):158,968
Last modified:July 11, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1118403F098DAFC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W6RQW7W6RQW7_CAEEL
Non-specific serine/threonine prote...
dapk-1 CELE_K12C11.4, K12C11.4
927Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
W6RTC2W6RTC2_CAEEL
Non-specific serine/threonine prote...
dapk-1 CELE_K12C11.4, K12C11.4
1,264Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
W6SBC4W6SBC4_CAEEL
Non-specific serine/threonine prote...
dapk-1 CELE_K12C11.4, K12C11.4
1,029Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY733040 mRNA Translation: AAW57534.1
BX284601 Genomic DNA Translation: CCD72943.1

Protein sequence database of the Protein Information Resource

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PIRi
T32930

NCBI Reference Sequences

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RefSeqi
NP_490840.2, NM_058439.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K12C11.4a.1; K12C11.4a.1; WBGene00003400

Database of genes from NCBI RefSeq genomes

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GeneIDi
187322

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_K12C11.4

UCSC genome browser

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UCSCi
K12C11.4, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY733040 mRNA Translation: AAW57534.1
BX284601 Genomic DNA Translation: CCD72943.1
PIRiT32930
RefSeqiNP_490840.2, NM_058439.4

3D structure databases

SMRiO44997
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi52023, 1 interactor
STRINGi6239.K12C11.4

Proteomic databases

EPDiO44997
PaxDbiO44997
PeptideAtlasiO44997

Genome annotation databases

EnsemblMetazoaiK12C11.4a.1; K12C11.4a.1; WBGene00003400
GeneIDi187322
KEGGicel:CELE_K12C11.4
UCSCiK12C11.4, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
187322
WormBaseiK12C11.4 ; CE40262 ; WBGene00003400 ; dapk-1

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
HOGENOMiCLU_002849_2_0_1
InParanoidiO44997
OMAiWRKMNGP
OrthoDBi67579at2759
PhylomeDBiO44997

Enzyme and pathway databases

SignaLinkiO44997

Miscellaneous databases

Protein Ontology

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PROi
PR:O44997

Gene expression databases

BgeeiWBGene00003400, Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues
ExpressionAtlasiO44997, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR011009, Kinase-like_dom_sf
IPR027417, P-loop_NTPase
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR020859, ROC_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF00531, Death, 1 hit
PF00069, Pkinase, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 9 hits
SM00005, DEATH, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 7 hits
PS50017, DEATH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS51424, ROC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAPK_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O44997
Secondary accession number(s): Q3ZLV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 11, 2006
Last modified: April 7, 2021
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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