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UniProtKB - O44770 (KATIP_CAEEL)
Protein
Protein KATNIP homolog
Gene
K04F10.2
Organism
Caenorhabditis elegans
Status
Functioni
May regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity.
1 PublicationNames & Taxonomyi
Protein namesi | Recommended name: Protein KATNIP homolog |
Gene namesi | ORF Names:K04F10.2Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | K04F10.2 ; CE53694 ; WBGene00019395 |
Subcellular locationi
Cytoskeleton
- cilium axoneme 1 Publication
- cilium basal body 1 Publication
Note: Accumulates at the ciliary base, proximal to the transition zone, and within the proximal ciliary axoneme (middle segment and transition zone) (PubMed:26714646). Does not undergo processive movement within the ciliary axonemes or the neuronal processes (PubMed:26714646).1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-KW
Other locations
- cell projection Source: UniProtKB-KW
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Disruption phenotypei
No obvious phenotype. Ultrastructural analyzes reveal disruption of ciliary microtubule load and organization, although various aspects of gross cilium length, function and transport are mostly normal.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000436066 | 1 – 568 | Protein KATNIP homologAdd BLAST | 568 |
Proteomic databases
PaxDbi | O44770 |
Expressioni
Tissue specificityi
Expressed in most ciliated neuronal cells (PubMed:26714646). Not expressed in non-ciliated cells (PubMed:26714646).1 Publication
Gene expression databases
Bgeei | WBGene00019395, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | O44770, 3 interactors |
STRINGi | 6239.K04F10.2 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | ENOG502QRY1, Eukaryota |
GeneTreei | ENSGT00390000004566 |
HOGENOMi | CLU_003418_2_1_1 |
InParanoidi | O44770 |
OMAi | HIALIRI |
OrthoDBi | 361541at2759 |
PhylomeDBi | O44770 |
Family and domain databases
InterProi | View protein in InterPro IPR026704, KATNIP IPR027859, KATNIP_dom |
PANTHERi | PTHR21534, PTHR21534, 1 hit |
Pfami | View protein in Pfam PF14652, DUF4457, 3 hits |
i Sequence
Sequence statusi: Complete.
O44770-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDSDLKEIE KNAENIKLEP AEDEVNEEDQ NEITIPELPE GRVLELRLLS
60 70 80 90 100
NWGDSHYIGL NSVEIFTSTG ERAVIDKVTT NVTEYTGSLE SLIVQRVHCK
110 120 130 140 150
DAEKMWCAKT TEEKIVLTLE LKETCKLALI RFWNYNASRV HAQIGVRYLE
160 170 180 190 200
MYLDGVGIFR GELECAFSAD SEFTPVMGET VLFTTSDNIL ELIALHDVCL
210 220 230 240 250
ISLPEEPISN SSIEMLKADH LTPYRPSTCE AKDAPSTPVT IVPPPIFRQT
260 270 280 290 300
GTAYKHDVKT LHIELLSNWG MDGLIGLTGL ELVDEHSQLI DESQYTVTTS
310 320 330 340 350
DGNSDLSKKL FNGRNLTRDP HDMWLVDFDS KNFTTISITF HDNVALKAIS
360 370 380 390 400
VWNYNASFEL SYAGVKAAKI YINGKLIKNV LLRKATGFVY FDYVQDVVLD
410 420 430 440 450
PNNTERDFVP KGISQSIGGF VFQIRLLSTW GDEFYIGLNG IELYNRKGEL
460 470 480 490 500
MKIREHNLAA FPESVNILPN IKNDLRTSNN LITQPNDTDI ARNMWLTALL
510 520 530 540 550
PNRCARVFFV FDVQTYISKI VIYNYRKTPE RGVRHISVTV DDLIIFSGEI
560
PSSTATLTGN LEINLMDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284601 Genomic DNA Translation: CCD70034.2 |
PIRi | B87804 |
RefSeqi | NP_491836.2, NM_059435.2 |
Genome annotation databases
EnsemblMetazoai | K04F10.2.1; K04F10.2.1; WBGene00019395 |
UCSCi | K04F10.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284601 Genomic DNA Translation: CCD70034.2 |
PIRi | B87804 |
RefSeqi | NP_491836.2, NM_059435.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O44770, 3 interactors |
STRINGi | 6239.K04F10.2 |
Proteomic databases
PaxDbi | O44770 |
Genome annotation databases
EnsemblMetazoai | K04F10.2.1; K04F10.2.1; WBGene00019395 |
UCSCi | K04F10.2, c. elegans |
Organism-specific databases
WormBasei | K04F10.2 ; CE53694 ; WBGene00019395 |
Phylogenomic databases
eggNOGi | ENOG502QRY1, Eukaryota |
GeneTreei | ENSGT00390000004566 |
HOGENOMi | CLU_003418_2_1_1 |
InParanoidi | O44770 |
OMAi | HIALIRI |
OrthoDBi | 361541at2759 |
PhylomeDBi | O44770 |
Miscellaneous databases
PROi | PR:O44770 |
Gene expression databases
Bgeei | WBGene00019395, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR026704, KATNIP IPR027859, KATNIP_dom |
PANTHERi | PTHR21534, PTHR21534, 1 hit |
Pfami | View protein in Pfam PF14652, DUF4457, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KATIP_CAEEL | |
Accessioni | O44770Primary (citable) accession number: O44770 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 11, 2016 |
Last sequence update: | April 7, 2021 | |
Last modified: | September 29, 2021 | |
This is version 112 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase