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Protein

M-phase inducer phosphatase cdc-25.1

Gene

cdc-25.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: WormBase
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: WormBase
  • meiotic cell cycle Source: WormBase
  • meiotic spindle organization Source: WormBase
  • positive regulation of cell cycle G2/M phase transition Source: InterPro

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-CEL-156711 Polo-like kinase mediated events
R-CEL-5625740 RHO GTPases activate PKNs
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase cdc-25.1 (EC:3.1.3.48)
Alternative name(s):
Cell division cycle-related protein 25.1
Gene namesi
ORF Names:K06A5.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK06A5.7 ; CE11778 ; WBGene00000386 ; cdc-25.1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986551 – 604M-phase inducer phosphatase cdc-25.1Add BLAST604

Proteomic databases

EPDiO44552
PaxDbiO44552
PeptideAtlasiO44552

PTM databases

iPTMnetiO44552

Expressioni

Gene expression databases

BgeeiWBGene00000386

Interactioni

Protein-protein interaction databases

BioGridi37805, 8 interactors
DIPiDIP-25238N
STRINGi6239.K06A5.7.2

Structurei

3D structure databases

ProteinModelPortaliO44552
SMRiO44552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini305 – 413RhodanesePROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 100Ser-richAdd BLAST59

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3772 Eukaryota
COG5105 LUCA
GeneTreeiENSGT00390000018747
HOGENOMiHOG000019787
InParanoidiO44552
OMAiHVEYPEM
OrthoDBiEOG091G0866

Family and domain databases

CDDicd01530 Cdc25, 1 hit
Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR000751 MPI_Phosphatase
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PRINTSiPR00716 MPIPHPHTASE
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit

Sequencei

Sequence statusi: Complete.

O44552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTGEKAIY EDQNNVNIIE NVVDVANGIN ESPKTLFEED GSSRDSGVSM
60 70 80 90 100
TSCSDKSDAS PEEDVDFSKL ESGRVALTDC SNFVSILQRN SSVSSSRSSS
110 120 130 140 150
FYNYDTPTGR KMKTVFDLDS LDHSEYEKRV MSERPTDNHR KRTSSSMSPS
160 170 180 190 200
VTLLDRKRSR NLSLVAPQSD KSCRYNGLNN PRDDPFGDED DEVFEQSNVR
210 220 230 240 250
NSQVQNTSIF AQPAPRTATS LWDLAPPMFF ERKTSDTSGN GSFQERPKQI
260 270 280 290 300
LRAMSVGEID SELPPTLEVK YTLPGVDNPQ RESQAFRSIS PTTLLLEFQR
310 320 330 340 350
LGDDFDKKYI IVDCRFPFEY KGGHVKGAIN LFRHDKIKPI FFPENGEASS
360 370 380 390 400
FQNRVPIFYC EYSQKRGPTM AHAVRSIDRV LNELRYPHVE YPEMYLLDYG
410 420 430 440 450
YKSLWSTAEC RQICEPCSYI PMTHSSFSME FKSARLERHH SMASLKPNGE
460 470 480 490 500
TSHREEKKKR CTRSVIRRNN SSLNMLSRSS SALTSTGSKT SSMENILYGL
510 520 530 540 550
DDERRPKWVS AFDIQSTESE NDLDAALIYQ RNISSNASNA SSIVNLAEER
560 570 580 590 600
IVQLGLQVIT PDFPDRPSES SSTTPAGEHL PLGEGGHQIP CGILDFSSIS

DDAE
Length:604
Mass (Da):67,892
Last modified:June 1, 1998 - v1
Checksum:i70721C95FA9F40DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080960 Genomic DNA Translation: CCD68116.1
PIRiT15091
RefSeqiNP_491862.1, NM_059461.3
UniGeneiCel.17290

Genome annotation databases

EnsemblMetazoaiK06A5.7.1; K06A5.7.1; WBGene00000386
K06A5.7.2; K06A5.7.2; WBGene00000386
GeneIDi172353
KEGGicel:CELE_K06A5.7
UCSCiK06A5.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiMPIP1_CAEEL
AccessioniPrimary (citable) accession number: O44552
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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