UniProtKB - O44424 (ESS2_DROME)
Protein
Splicing factor ESS-2 homolog
Gene
Es2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Biological processi
- mRNA splicing, via spliceosome Source: FlyBase
- nervous system development Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Splicing factor ESS-2 homologAlternative name(s): Protein Es2 dEs2 |
Gene namesi | Name:Es2 ORF Names:CG1474 |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0023506, Es2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- catalytic step 2 spliceosome Source: FlyBase
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079875 | 1 – 501 | Splicing factor ESS-2 homologAdd BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 409 | Phosphoserine1 Publication | 1 | |
Modified residuei | 411 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | O44424 |
PTM databases
iPTMneti | O44424 |
Expressioni
Gene expression databases
Bgeei | FBgn0023506, Expressed in imaginal disc and 19 other tissues |
ExpressionAtlasi | O44424, baseline and differential |
Genevisiblei | O44424, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 58239, 33 interactors |
DIPi | DIP-18468N |
IntActi | O44424, 5 interactors |
STRINGi | 7227.FBpp0071145 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ESS2 family.Curated
Phylogenomic databases
eggNOGi | KOG2627, Eukaryota |
GeneTreei | ENSGT00390000009387 |
HOGENOMi | CLU_024820_0_1_1 |
InParanoidi | O44424 |
OMAi | PGYKTPA |
OrthoDBi | 1378245at2759 |
PhylomeDBi | O44424 |
Family and domain databases
InterProi | View protein in InterPro IPR019148, Nuclear_protein_DGCR14_ESS-2 |
PANTHERi | PTHR12940, PTHR12940, 1 hit |
Pfami | View protein in Pfam PF09751, Es2, 1 hit |
i Sequence
Sequence statusi: Complete.
O44424-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSATTRTPAT PGTPGTPGSL AMEVARVQNS ALAEFKKPTA MVRHKNKPKI
60 70 80 90 100
LTEEKYIEEM SKIIQRDFFP DLERLRAQND YLDAESRRDF VQMAEIRERY
110 120 130 140 150
SLGRISGTGR STSRRNNAMS PATFETPVSQ AKCSNTPLPN SRATDTPFST
160 170 180 190 200
DGSEKSDAEG RDTTAKLSLD AFLQKYTSED NQSFQEIIET AEAKLRQKYA
210 220 230 240 250
VLYNHEKLSA EQLQRALMLP SIETQFEEPD PLRKIETWNY TNMNSIMYVP
260 270 280 290 300
DGVEYTEEER VQLAERKQSI QHNATRLPDE AKHREMDTKK LNDEVPQNGA
310 320 330 340 350
GGATATPKVR GFDLLRSPSP RPGEAFSPIM TWGEIDGTPF RLDGGDTPLR
360 370 380 390 400
PTQGPSFRIN ENSRRENIAI ALAERVSERM RNQKQMALDT ARRNIGSPLI
410 420 430 440 450
RTNMERLASM SPAAQLLATG KLGIRGTPRL RHTPSPMSGR KRKVTPGVVR
460 470 480 490 500
STNTPILGEP KPKQQAKIST PAKNVTIDTG STLTDDLLKI PTKRRTAADF
F
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 142 | R → W in AAL39937 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 166 – 167 | KL → NV in AAC04785 (PubMed:9499415).Curated | 2 | |
Sequence conflicti | 381 – 383 | RNQ → PNP in AAC04785 (PubMed:9499415).Curated | 3 | |
Sequence conflicti | 469 | S → N in AAC04785 (PubMed:9499415).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF46375.1 AY069792 mRNA Translation: AAL39937.1 AF037257 mRNA Translation: AAC04785.1 |
RefSeqi | NP_572480.1, NM_132252.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0071198; FBpp0071145; FBgn0023506 |
GeneIDi | 31780 |
KEGGi | dme:Dmel_CG1474 |
UCSCi | CG1474-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF46375.1 AY069792 mRNA Translation: AAL39937.1 AF037257 mRNA Translation: AAC04785.1 |
RefSeqi | NP_572480.1, NM_132252.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 58239, 33 interactors |
DIPi | DIP-18468N |
IntActi | O44424, 5 interactors |
STRINGi | 7227.FBpp0071145 |
PTM databases
iPTMneti | O44424 |
Proteomic databases
PaxDbi | O44424 |
Genome annotation databases
EnsemblMetazoai | FBtr0071198; FBpp0071145; FBgn0023506 |
GeneIDi | 31780 |
KEGGi | dme:Dmel_CG1474 |
UCSCi | CG1474-RA, d. melanogaster |
Organism-specific databases
CTDi | 109579 |
FlyBasei | FBgn0023506, Es2 |
Phylogenomic databases
eggNOGi | KOG2627, Eukaryota |
GeneTreei | ENSGT00390000009387 |
HOGENOMi | CLU_024820_0_1_1 |
InParanoidi | O44424 |
OMAi | PGYKTPA |
OrthoDBi | 1378245at2759 |
PhylomeDBi | O44424 |
Miscellaneous databases
BioGRID-ORCSi | 31780, 0 hits in 1 CRISPR screen |
GenomeRNAii | 31780 |
PROi | PR:O44424 |
Gene expression databases
Bgeei | FBgn0023506, Expressed in imaginal disc and 19 other tissues |
ExpressionAtlasi | O44424, baseline and differential |
Genevisiblei | O44424, DM |
Family and domain databases
InterProi | View protein in InterPro IPR019148, Nuclear_protein_DGCR14_ESS-2 |
PANTHERi | PTHR12940, PTHR12940, 1 hit |
Pfami | View protein in Pfam PF09751, Es2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ESS2_DROME | |
Accessioni | O44424Primary (citable) accession number: O44424 Secondary accession number(s): Q8T9F3, Q9W3F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2003 |
Last sequence update: | June 16, 2003 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families