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Entry version 151 (12 Aug 2020)
Sequence version 2 (01 Oct 2003)
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Protein

Glutamyl-tRNA synthetase

Gene

ears-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationARBA annotation, Ligase
Biological processProtein biosynthesisUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamyl-tRNA synthetaseARBA annotation (EC:6.1.1.17ARBA annotation)
Alternative name(s):
Probable glutamate--tRNA ligase, mitochondrialARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ears-2Imported
ORF Names:CELE_T07A9.2Imported, T07A9.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

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WormBasei
T07A9.2 ; CE34997 ; WBGene00001338 ; ears-2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O44413

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O44413

PeptideAtlas

More...
PeptideAtlasi
O44413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001338, Expressed in germ line (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T07A9.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O44413

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 327tRNA-synt_1cInterPro annotationAdd BLAST318

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1149, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015768_6_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O44413

KEGG Orthology (KO)

More...
KOi
K01885

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGDFILM

Database of Orthologous Groups

More...
OrthoDBi
879920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O44413

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00808, GluRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.350, 1 hit
3.40.50.620, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00022, Glu_tRNA_synth_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008925, aa-tRNA-synth_I_codon-bd
IPR020751, aa-tRNA-synth_I_codon-bd_sub2
IPR001412, aa-tRNA-synth_I_CS
IPR004527, Glu-tRNA-ligase_bac/mito
IPR000924, Glu/Gln-tRNA-synth
IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910, GluRS_core
IPR014729, Rossmann-like_a/b/a_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00749, tRNA-synt_1c, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00987, TRNASYNTHGLU

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48163, SSF48163, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00464, gltX_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O44413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLTGFLKQN VRVRFAPSPT GHLHIGGLRT AFFNYLFAKK YGGDFILRIE
60 70 80 90 100
DTDRTRFVDD AQDQIYSSLN FYNLLPDEGP REGGKFGPYE QSKRLEIYRN
110 120 130 140 150
AAYRLIDSGH AYRCFCSENR LDLLRKTAEK RGEIPKYDRK CANLSSRDAV
160 170 180 190 200
KMEQNGEKFV IRFKLDKQNV QFHDEVFGSV NQFIDESDPV LLKSDGFPTY
210 220 230 240 250
HLANVIDDRK MEISHVIRGM EWLSSTGKHT ILYKAFNWTP PKFVHLSLIM
260 270 280 290 300
RSATKKLSKR DKDAFVSYYS EQLGALPEAV LNLMIRNGAG IRNFDAEHFY
310 320 330 340 350
SLDEMIEQFD LSLLGRRNLL LDSDVLQKYS RMAFQKSDFK ELYPRIIDIL
360 370 380 390 400
NKKSNYSTSR EDIQKIVTFL KAKEENFGFL SSLSTEFSWF FTRPQSSQLL
410 420 430 440 450
KESHPNVDLR NILNSLLEIE VFNSESLEYL AKNHQLNLAK AMGIVRISLI
460 470 480
GSKKGPPISE LVEFFGMTEC HRRIRIMQEL L
Length:481
Mass (Da):55,800
Last modified:October 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9E244CC24E668CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD73973.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T32582

NCBI Reference Sequences

More...
RefSeqi
NP_499917.2, NM_067516.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T07A9.2.1; T07A9.2.1; WBGene00001338

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176860

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T07A9.2

UCSC genome browser

More...
UCSCi
T07A9.2, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD73973.1
PIRiT32582
RefSeqiNP_499917.2, NM_067516.4

3D structure databases

SMRiO44413
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.T07A9.2

Proteomic databases

EPDiO44413
PaxDbiO44413
PeptideAtlasiO44413

Genome annotation databases

EnsemblMetazoaiT07A9.2.1; T07A9.2.1; WBGene00001338
GeneIDi176860
KEGGicel:CELE_T07A9.2
UCSCiT07A9.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176860
WormBaseiT07A9.2 ; CE34997 ; WBGene00001338 ; ears-2

Phylogenomic databases

eggNOGiKOG1149, Eukaryota
GeneTreeiENSGT00390000009759
HOGENOMiCLU_015768_6_3_1
InParanoidiO44413
KOiK01885
OMAiEGDFILM
OrthoDBi879920at2759
PhylomeDBiO44413

Gene expression databases

BgeeiWBGene00001338, Expressed in germ line (C elegans) and 5 other tissues

Family and domain databases

CDDicd00808, GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022, Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925, aa-tRNA-synth_I_codon-bd
IPR020751, aa-tRNA-synth_I_codon-bd_sub2
IPR001412, aa-tRNA-synth_I_CS
IPR004527, Glu-tRNA-ligase_bac/mito
IPR000924, Glu/Gln-tRNA-synth
IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910, GluRS_core
IPR014729, Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749, tRNA-synt_1c, 1 hit
PRINTSiPR00987, TRNASYNTHGLU
SUPFAMiSSF48163, SSF48163, 1 hit
TIGRFAMsiTIGR00464, gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO44413_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O44413
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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