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UniProtKB - O44390 (ACO11_TRINI)
Protein
Acyl-CoA Delta(11) desaturase
Gene
D11DS
Organism
Trichoplusia ni (Cabbage looper)
Status
Functioni
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.
1 PublicationCatalytic activityi
- an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-Δ11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O1 PublicationEC:1.14.19.51 Publication
Cofactori
Fe cationBy similarity
GO - Molecular functioni
- acyl-CoA delta11-desaturase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- myristoyl-CoA 11-(Z) desaturase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.19.5, 6461 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA Delta(11) desaturase (EC:1.14.19.51 Publication)Alternative name(s): Acyl-CoA Delta-11 desaturase Short name: Delta(11)-desaturase |
Gene namesi | Name:D11DS Synonyms:PGD11DS |
Organismi | Trichoplusia ni (Cabbage looper) |
Taxonomic identifieri | 7111 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Noctuoidea › Noctuidae › Plusiinae › Trichoplusia |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 184 – 204 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 282 – 302 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185410 | 1 – 349 | Acyl-CoA Delta(11) desaturaseAdd BLAST | 349 |
Expressioni
Tissue specificityi
Adult female pheromone gland. Increases by two or three orders of magnitude during the first 2 days after adult eclosion.1 Publication
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 86 – 91 | Histidine box-1 | 6 | |
Motifi | 123 – 127 | Histidine box-2 | 5 | |
Motifi | 263 – 267 | Histidine box-3 | 5 |
Domaini
The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity
Sequence similaritiesi
Belongs to the fatty acid desaturase type 1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd03505, Delta9-FADS-like, 1 hit |
InterProi | View protein in InterPro IPR015876, Acyl-CoA_DS IPR005804, FA_desaturase_dom IPR001522, FADS-1_CS |
PANTHERi | PTHR11351, PTHR11351, 1 hit |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
PRINTSi | PR00075, FACDDSATRASE |
PROSITEi | View protein in PROSITE PS00476, FATTY_ACID_DESATUR_1, 1 hit |
i Sequence
Sequence statusi: Complete.
O44390-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVMAQTVQE TATVLEEEAR TVTLVAPKTT PRKYKYIYTN FLTFSYAHLA
60 70 80 90 100
ALYGLYLCFT SAKWETLLFS FVLFHMSNIG ITAGAHRLWT HKTFKAKLPL
110 120 130 140 150
EIVLMIFNSL AFQNTAITWA REHRLHHKYS DTDADPHNAS RGFFYSHVGW
160 170 180 190 200
LLVKKHPDVL KYGKTIDMSD VYNNPVLKFQ KKYAVPLIGT VCFALPTLIP
210 220 230 240 250
VYCWGESWNN AWHIALFRYI FNLNVTFLVN SAAHIWGNKP YDKSILPAQN
260 270 280 290 300
LLVSFLASGE GFHNYHHVFP WDYRTAELGN NFLNLTTLFI DFCAWFGWAY
310 320 330 340
DLKSVSEDII KQRAKRTGDG SSGVIWGWDD KDMDRDIKSK ANIFYAKKE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | V → M in AAK21863 (PubMed:11483431).Curated | 1 | |
Sequence conflicti | 116 | A → V in AAK21863 (PubMed:11483431).Curated | 1 | |
Sequence conflicti | 125 – 135 | LHHKYSDTDAD → YITNTAILMLI in AAK21863 (PubMed:11483431).CuratedAdd BLAST | 11 | |
Sequence conflicti | 257 | A → T in AAK21864 (PubMed:11483431).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035375 mRNA Translation: AAD03775.1 AF297114 Genomic DNA Translation: AAK21864.1 AF297113 Genomic DNA Translation: AAK21863.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035375 mRNA Translation: AAD03775.1 AF297114 Genomic DNA Translation: AAK21864.1 AF297113 Genomic DNA Translation: AAK21863.1 |
3D structure databases
SMRi | O44390 |
ModBasei | Search... |
Enzyme and pathway databases
BRENDAi | 1.14.19.5, 6461 |
Family and domain databases
CDDi | cd03505, Delta9-FADS-like, 1 hit |
InterProi | View protein in InterPro IPR015876, Acyl-CoA_DS IPR005804, FA_desaturase_dom IPR001522, FADS-1_CS |
PANTHERi | PTHR11351, PTHR11351, 1 hit |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
PRINTSi | PR00075, FACDDSATRASE |
PROSITEi | View protein in PROSITE PS00476, FATTY_ACID_DESATUR_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACO11_TRINI | |
Accessioni | O44390Primary (citable) accession number: O44390 Secondary accession number(s): Q9BKA3, Q9BKA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | January 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 82 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families