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Protein

Acyl-CoA Delta(11) desaturase

Gene

D11DS

Organism
Trichoplusia ni (Cabbage looper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.1 Publication

Catalytic activityi

An acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11Z)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O.1 Publication

Cofactori

Fe cationBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18385
BRENDAi1.14.19.5 6461

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA Delta(11) desaturase (EC:1.14.19.51 Publication)
Alternative name(s):
Acyl-CoA Delta-11 desaturase
Short name:
Delta(11)-desaturase
Gene namesi
Name:D11DS
Synonyms:PGD11DS
OrganismiTrichoplusia ni (Cabbage looper)
Taxonomic identifieri7111 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaePlusiinaeTrichoplusia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854101 – 349Acyl-CoA Delta(11) desaturaseAdd BLAST349

Expressioni

Tissue specificityi

Adult female pheromone gland. Increases by two or three orders of magnitude during the first 2 days after adult eclosion.1 Publication

Structurei

3D structure databases

SMRiO44390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi86 – 91Histidine box-16
Motifi123 – 127Histidine box-25
Motifi263 – 267Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
IPR001522 FADS-1_CS
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PRINTSiPR00075 FACDDSATRASE
PROSITEiView protein in PROSITE
PS00476 FATTY_ACID_DESATUR_1, 1 hit

Sequencei

Sequence statusi: Complete.

O44390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAQTVQE TATVLEEEAR TVTLVAPKTT PRKYKYIYTN FLTFSYAHLA
60 70 80 90 100
ALYGLYLCFT SAKWETLLFS FVLFHMSNIG ITAGAHRLWT HKTFKAKLPL
110 120 130 140 150
EIVLMIFNSL AFQNTAITWA REHRLHHKYS DTDADPHNAS RGFFYSHVGW
160 170 180 190 200
LLVKKHPDVL KYGKTIDMSD VYNNPVLKFQ KKYAVPLIGT VCFALPTLIP
210 220 230 240 250
VYCWGESWNN AWHIALFRYI FNLNVTFLVN SAAHIWGNKP YDKSILPAQN
260 270 280 290 300
LLVSFLASGE GFHNYHHVFP WDYRTAELGN NFLNLTTLFI DFCAWFGWAY
310 320 330 340
DLKSVSEDII KQRAKRTGDG SSGVIWGWDD KDMDRDIKSK ANIFYAKKE
Length:349
Mass (Da):40,243
Last modified:January 1, 1999 - v2
Checksum:iF91AF7A2F59F0450
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22V → M in AAK21863 (PubMed:11483431).Curated1
Sequence conflicti116A → V in AAK21863 (PubMed:11483431).Curated1
Sequence conflicti125 – 135LHHKYSDTDAD → YITNTAILMLI in AAK21863 (PubMed:11483431).CuratedAdd BLAST11
Sequence conflicti257A → T in AAK21864 (PubMed:11483431).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035375 mRNA Translation: AAD03775.1
AF297114 Genomic DNA Translation: AAK21864.1
AF297113 Genomic DNA Translation: AAK21863.1

Similar proteinsi

Entry informationi

Entry nameiACO11_TRINI
AccessioniPrimary (citable) accession number: O44390
Secondary accession number(s): Q9BKA3, Q9BKA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 1, 1999
Last modified: April 25, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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