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Entry version 122 (31 Jul 2019)
Sequence version 1 (01 Jun 1998)
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Protein
Submitted name:

Receptor tyrosine phosphatase

Gene

HmLAR1

Organism
Hirudo medicinalis (Medicinal leech)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1071Phosphocysteine intermediatePROSITE-ProRule annotation1
Active sitei1362Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation, ReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Receptor tyrosine phosphataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HmLAR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHirudo medicinalis (Medicinal leech)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6421 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudineaHirudinidaHirudiniformesHirudinidaeHirudo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei780 – 803HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500415906127 – 1437Sequence analysisAdd BLAST1411

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 127Ig-likeInterPro annotationAdd BLAST93
Domaini139 – 226Ig-likeInterPro annotationAdd BLAST88
Domaini234 – 316Ig-likeInterPro annotationAdd BLAST83
Domaini323 – 418Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini423 – 520Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini524 – 628Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini875 – 1130Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini1050 – 1121TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1162 – 1428Tyrosine-protein phosphataseInterPro annotationAdd BLAST267
Domaini1339 – 1412TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 6 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O44329-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLPAGRAIN TRYLATSLVM ITCSLAYMVD HDDAPRITTA PRDQKVMEGK
60 70 80 90 100
IASFFCKASG NPAPEVYWKR GWKESLHDKN ETKTSNMPHG SVLRVDPTKW
110 120 130 140 150
QKDETIIECV AESGIGHQAA TATARLHIYR ENEEPKGFPR LLETPEMRSV
160 170 180 190 200
EKDRNFILKC SATGDPEPSV YWLKDNIPVD MSDKRIQVLP GGSLSIRNGQ
210 220 230 240 250
GSDEGKYECV AENIHGTVHS FPASLYIRIR RVPPHFSVQI QNKEVPLGGS
260 270 280 290 300
LNVTCVVGGA PMPHVRWKHG DIDLTPENNI PIGKNVLRLE DVKQSGTYKC
310 320 330 340 350
IGSSELGNVE QEINVTVVVP AGAPQNITIH PFGSSATSAK LQWNAPDIRI
360 370 380 390 400
KQGDSTLYEV VYHLRQDQNK EWSTNITEEF IIFENLLPNS EYIFQIRAHT
410 420 430 440 450
YKGPGPWSYQ LPFKTPPFQF PNPPTDILIR RVHSTEMEVS WVAPTPLRGV
460 470 480 490 500
SGYRIYYNEV ALSDIDMWKF VDVDSPYTTT LEISNLEPYS VYTVRVRAKY
510 520 530 540 550
SDGSFGNLSE TAYSNKLEDE HPEMVREFQS QVLDSKTIVL QWKAPRKAGL
560 570 580 590 600
SRYQIEYEGR KRVSSDHTGL EETVIDTKKS FQVEKGAQSF RIENLLSNTL
610 620 630 640 650
YSINITAKFI DGITGPPYQL RVETSPSDPP VLEAPTLLRV TGDLLVVMRL
660 670 680 690 700
SLPSVQPMYD NVQYYVVVVP ANERRGPESV HIDELKGPHR DGWIASRFDG
710 720 730 740 750
MLPREMNLGD GSRSAVGEFI NHRLRKDQIY KVFIRSIIPG SKFHFYVQIM
760 770 780 790 800
SSSSPYSAPF SLDRLTMEIK GHPISANFDL LWIVGPMCAA IVLILLVVLI
810 820 830 840 850
IIFNRNRNRE NNSKRYLLPR QPTKIMPSAD LSIHPTDPVR RLQYQTQAMA
860 870 880 890 900
CHPSIPISEF AAHVEQLKAC NGARFSQEYE SIEPGQQFTW EASSLDCNKP
910 920 930 940 950
KNRYANVIAY DHSRVVLQSL EGISGSDYIN ANFMDGYRKS NAYIATQGPL
960 970 980 990 1000
PETFVDFWRM VWEQRVTTIV MMTKLEERGR IKCDQYWPNR GTEVYGPMHV
1010 1020 1030 1040 1050
TLVDVVELAI YTLRTFIVTK TGQQERIEVK QFQFTAWPDH GVPEHPTALL
1060 1070 1080 1090 1100
MFHRRVRSFH TVDSGPMVVH CSAGVGRTGR FIVVDRMLER ALHEKTIDVY
1110 1120 1130 1140 1150
GHVTCLRAQR NYMVQTEDQY IFVHDAILEG VTSGCTEVPA RNLYAHMQKL
1160 1170 1180 1190 1200
MSLESGSNLT LMEVEFKKLA NIKTSSSQFA SASLPSNKFK NRLVNILPYE
1210 1220 1230 1240 1250
SSRVTLQLIR GVDGSDYINA NFIDGYRYKK AYIATQGPLA STTEDFWRML
1260 1270 1280 1290 1300
WEHNSTIVVM LVKLREMGRE KCLQYWPSER SARYQYFVVD PMVEYNMPQY
1310 1320 1330 1340 1350
ILREFKVTDA RDGQSRTIRQ FQFTDWPEQG VPKSGEGFVD FIGQVHKTKE
1360 1370 1380 1390 1400
QFGQDGPITV HCGAGVSRTG VFIALSVVLE RMRYEGVVDL FQTVRLLRTQ
1410 1420 1430
RPCCVKLRLQ VQTPEDHYAF CYRAALEYLG SFRHYAN
Length:1,437
Mass (Da):163,549
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0084E7949B3FF716
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF017084 mRNA Translation: AAB91461.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T31093

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017084 mRNA Translation: AAB91461.1
PIRiT31093

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 6 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO44329_HIRME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O44329
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 31, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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