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Entry version 133 (07 Apr 2021)
Sequence version 1 (01 Jun 1998)
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Protein

DNA repair protein rad-50

Gene

rad-50

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per homodimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi666ZincPROSITE-ProRule annotation1
Metal bindingi669ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi36 – 43ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCell cycle, DNA damage, DNA repair, Meiosis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2559586, DNA Damage/Telomere Stress Induced Senescence
R-CEL-5685939, HDR through MMEJ (alt-NHEJ)
R-CEL-5693548, Sensing of DNA Double Strand Breaks
R-CEL-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-5693607, Processing of DNA double-strand break ends

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein rad-50 (EC:3.6.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rad-50
ORF Names:T04H1.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
T04H1.4a ; CE21149 ; WBGene00004296 ; rad-50

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001386441 – 1298DNA repair protein rad-50Add BLAST1298

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O44199

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O44199

PRoteomics IDEntifications database

More...
PRIDEi
O44199

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004296, Expressed in material anatomical entity and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O44199, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Probable component of the MRN complex with mre-11 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
44701, 3 interactors

Protein interaction database and analysis system

More...
IntActi
O44199, 1 interactor

Molecular INTeraction database

More...
MINTi
O44199

STRING: functional protein association networks

More...
STRINGi
6239.T04H1.4b.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O44199

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini622 – 719Zinc-hookPROSITE-ProRule annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili222 – 291Sequence analysisAdd BLAST70
Coiled coili317 – 598Sequence analysisAdd BLAST282
Coiled coili622 – 660Sequence analysisAdd BLAST39
Coiled coili691 – 719Sequence analysisAdd BLAST29
Coiled coili754 – 1092Sequence analysisAdd BLAST339

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1174 – 1211Ala/Asp-rich (DA-box)Add BLAST38

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. RAD50 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0962, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006184_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O44199

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR038729, Rad50/SbcC_AAA
IPR004584, Rad50_eukaryotes
IPR013134, Zn_hook_RAD50

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13476, AAA_23, 1 hit
PF04423, Rad50_zn_hook, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00606, rad50, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51131, ZN_HOOK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O44199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKFLRLHIR GIRSVGDEDH DVHKIDFLSP CTLISGPNGT GKTTTIEALN
60 70 80 90 100
FVTTGQMPTQ KKQNFIHSTD VARKTRVDAS VTLEFIDVKG RECTAVRRLV
110 120 130 140 150
VTSGTKAAAL AEEHTLAIKY PDGTVNTLSS KVCDFNTALL KHLGVPRAVF
160 170 180 190 200
KYVIFCHQED STWPLSEPKE LKKRFDDIFQ LTKFVKAQER MKKIVLDFKK
210 220 230 240 250
EMQTHEMSKQ LYETHVRDKL VARQNQEECE RKISKRKEET DELKERKANG
260 270 280 290 300
QKKIEEMRTS IHELEDTLTS FKKTELERQN LKKQLSLIRV EPYFGTEEEL
310 320 330 340 350
KREIEEFRGS EGRSYGEERA RIQKKIGKNN QERQELSQKK TEFENRISSL
360 370 380 390 400
KAEVIHCQSL KYDLERLENQ LRSELDLEHD ADIDIEIDNA ITLKIRGMSD
410 420 430 440 450
KARMIAKNCA ELQSNLRTAQ EAATKIEVEM KTLQNEKVKL EKEVEQLKFK
460 470 480 490 500
IKQGQNATAG MKDLLKKEEA LRKSLADLPL LDENALTECK LKREKYLKQL
510 520 530 540 550
DILKKKCAEA EKNAEKDREK ESLKQTLSIA RKKMTAYQRI YDNNWQGLIG
560 570 580 590 600
QAPDFPWTPI LSKTFHKLRN DKKIMEEDLR DVQLNVQKLE TMQHQYRKQE
610 620 630 640 650
ESLTAQELKL SENIFEACSC EAEEVSEKLE NLRKRLKKAR KDLAPLSAKS
660 670 680 690 700
NLYDSYIEES KSSGCCPLCD RDFKTKKEIN EFSKKLENMT LSFPTEQEEL
710 720 730 740 750
EKLVSKLEKE EIIIVKAEGQ ANELQRIVKE LKEVREKNRK LSTEMAEEKS
760 770 780 790 800
NLSKNEKQLE TVNAKLKLAE DLQTDVGVIQ QLYEQTEENE KRYEQLVSES
810 820 830 840 850
DSSDGLSYTE LRKKVEDKDE EYRKIVQEGE ELQKCSEERN KLQSKLNELG
860 870 880 890 900
THRVSLGEAA AQAGAFAEQL ETKIKEIQEC ITAISQKRNE DLPDAQFKKD
910 920 930 940 950
DLTRNVSSKE EEKKKAEMEV QMMKKELDQK IFHRKSLFKK VQEGGLCERQ
960 970 980 990 1000
LMDKENNIAT LNASLEENQQ RQKRFEEDLR SFDSSHQRES ILKDQLTRMI
1010 1020 1030 1040 1050
IENKIKELKR TLATFDGQIN EDRITEQKQA YNKLQNELRL IGNEEVKIYT
1060 1070 1080 1090 1100
QMQEYEKQKK IAEAKLSTKE CQNAESNYRD AIIELAITKE SISDLTKYRN
1110 1120 1130 1140 1150
CLDASLIQFH SEKMGRVNGI IDDLWRKVYN STDITTIRIR SDATSETSSK
1160 1170 1180 1190 1200
KVAYEYNVMM VHETGTEVEM RGRCSAGQKM LASLLIRIAL AEVFGGSCSM
1210 1220 1230 1240 1250
IALDEPTTNL DESKVEGMAI VLADIIAERR GFDENGKLRG RDMQMVVITH
1260 1270 1280 1290
DERLVNRITI SCRPEYIYCL GKDEHGISFL SKRYPDGTVK RVNTKRRF
Length:1,298
Mass (Da):150,396
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2971F63E754A44E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5JYU5A5JYU5_CAEEL
Zinc-hook domain-containing protein
rad-50 CELE_T04H1.4, T04H1.4
1,312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z75312 mRNA Translation: CAA99730.1
Z78200 Genomic DNA Translation: CAB01581.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T24480

NCBI Reference Sequences

More...
RefSeqi
NP_506070.1, NM_073669.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T04H1.4a.1; T04H1.4a.1; WBGene00004296
T04H1.4a.2; T04H1.4a.2; WBGene00004296

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179678

UCSC genome browser

More...
UCSCi
T04H1.4b.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75312 mRNA Translation: CAA99730.1
Z78200 Genomic DNA Translation: CAB01581.1
PIRiT24480
RefSeqiNP_506070.1, NM_073669.6

3D structure databases

SMRiO44199
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi44701, 3 interactors
IntActiO44199, 1 interactor
MINTiO44199
STRINGi6239.T04H1.4b.1

Proteomic databases

EPDiO44199
PaxDbiO44199
PRIDEiO44199

Genome annotation databases

EnsemblMetazoaiT04H1.4a.1; T04H1.4a.1; WBGene00004296
T04H1.4a.2; T04H1.4a.2; WBGene00004296
GeneIDi179678
UCSCiT04H1.4b.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179678
WormBaseiT04H1.4a ; CE21149 ; WBGene00004296 ; rad-50

Phylogenomic databases

eggNOGiKOG0962, Eukaryota
GeneTreeiENSGT00390000018781
HOGENOMiCLU_006184_0_0_1
InParanoidiO44199

Enzyme and pathway databases

ReactomeiR-CEL-2559586, DNA Damage/Telomere Stress Induced Senescence
R-CEL-5685939, HDR through MMEJ (alt-NHEJ)
R-CEL-5693548, Sensing of DNA Double Strand Breaks
R-CEL-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-5693607, Processing of DNA double-strand break ends

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O44199

Gene expression databases

BgeeiWBGene00004296, Expressed in material anatomical entity and 5 other tissues
ExpressionAtlasiO44199, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR038729, Rad50/SbcC_AAA
IPR004584, Rad50_eukaryotes
IPR013134, Zn_hook_RAD50
PfamiView protein in Pfam
PF13476, AAA_23, 1 hit
PF04423, Rad50_zn_hook, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00606, rad50, 1 hit
PROSITEiView protein in PROSITE
PS51131, ZN_HOOK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD50_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O44199
Secondary accession number(s): Q22177
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 1998
Last modified: April 7, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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