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Protein
Submitted name:

RFC (DNA replication factor) family

Gene

rfc-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-110312 Translesion synthesis by REV1
R-CEL-110314 Recognition of DNA damage by PCNA-containing replication complex
R-CEL-110320 Translesion Synthesis by POLH
R-CEL-174411 Polymerase switching on the C-strand of the telomere
R-CEL-176187 Activation of ATR in response to replication stress
R-CEL-5696400 Dual Incision in GG-NER
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-69091 Polymerase switching

Names & Taxonomyi

Protein namesi
Submitted name:
RFC (DNA replication factor) familyImported
Gene namesi
Name:rfc-2Imported
ORF Names:CELE_F58F6.4Imported, F58F6.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF58F6.4 ; CE17139 ; WBGene00004338 ; rfc-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiO44175
PaxDbiO44175
PeptideAtlasiO44175

Expressioni

Gene expression databases

BgeeiWBGene00004338 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

DIPiDIP-26649N
IntActiO44175, 1 interactor
STRINGi6239.F58F6.4

Structurei

3D structure databases

ProteinModelPortaliO44175
SMRiO44175
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 174AAAInterPro annotationAdd BLAST133

Phylogenomic databases

eggNOGiKOG0991 Eukaryota
COG0470 LUCA
GeneTreeiENSGT00550000075050
HOGENOMiHOG000224155
InParanoidiO44175
KOiK10755
OMAiQSTWSGF
OrthoDBiEOG091G0CKT
PhylomeDBiO44175

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR027417 P-loop_NTPase
IPR013748 Rep_factorC_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08542 Rep_fac_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

O44175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSEKQQLA PWVEKYRPKV LADIVGNENI VERLKVIGHE GNVPNIVLSG
60 70 80 90 100
PPGCGKTTSV WALARELLGD KVKEAVLELN ASDERGIDVV RHRIKTFAQT
110 120 130 140 150
KVTLPEGRHK IIILDEADSM TDGAQQALRR TMEMYTKTTR FALACNQSEK
160 170 180 190 200
IIEPIQSRCA LLRYTKLSPV QLLTRVKEVA KAEKVNYDDG GLEAILFTAQ
210 220 230 240 250
GDMRQALNNL QATVNAYELV NKENVLKVCD EPHPDLMIKM LHYCTDRKFF
260 270 280 290 300
EASKIIHEFH RLGFSSDDIV STLFRVVKTV ELSKNVSEQL RMEYIRQIAM
310 320 330
CHMRIVQGLT SKLQLSRLIA DLCRVSAAAT ATSA
Length:334
Mass (Da):37,563
Last modified:June 1, 1998 - v1
Checksum:i2B4D6A08418DAA34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD63484.1
PIRiD88638
RefSeqiNP_500069.1, NM_067668.4
UniGeneiCel.7211

Genome annotation databases

EnsemblMetazoaiF58F6.4; F58F6.4; WBGene00004338
GeneIDi176946
KEGGicel:CELE_F58F6.4
UCSCiF58F6.4 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD63484.1
PIRiD88638
RefSeqiNP_500069.1, NM_067668.4
UniGeneiCel.7211

3D structure databases

ProteinModelPortaliO44175
SMRiO44175
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26649N
IntActiO44175, 1 interactor
STRINGi6239.F58F6.4

Proteomic databases

EPDiO44175
PaxDbiO44175
PeptideAtlasiO44175

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58F6.4; F58F6.4; WBGene00004338
GeneIDi176946
KEGGicel:CELE_F58F6.4
UCSCiF58F6.4 c. elegans

Organism-specific databases

CTDi176946
WormBaseiF58F6.4 ; CE17139 ; WBGene00004338 ; rfc-2

Phylogenomic databases

eggNOGiKOG0991 Eukaryota
COG0470 LUCA
GeneTreeiENSGT00550000075050
HOGENOMiHOG000224155
InParanoidiO44175
KOiK10755
OMAiQSTWSGF
OrthoDBiEOG091G0CKT
PhylomeDBiO44175

Enzyme and pathway databases

ReactomeiR-CEL-110312 Translesion synthesis by REV1
R-CEL-110314 Recognition of DNA damage by PCNA-containing replication complex
R-CEL-110320 Translesion Synthesis by POLH
R-CEL-174411 Polymerase switching on the C-strand of the telomere
R-CEL-176187 Activation of ATR in response to replication stress
R-CEL-5696400 Dual Incision in GG-NER
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-69091 Polymerase switching

Gene expression databases

BgeeiWBGene00004338 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR027417 P-loop_NTPase
IPR013748 Rep_factorC_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08542 Rep_fac_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO44175_CAEEL
AccessioniPrimary (citable) accession number: O44175
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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