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Protein

Pyruvate kinase

Gene

PYK

Organism
Eimeria tenella (Coccidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (ETH_00008865)
  2. Phosphoglycerate kinase (ETH_00040900), Phosphoglycerate kinase (ETH_00015140), Phosphoglycerate kinase (ETH_00027415), Phosphoglycerate kinase
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (PYK), Pyruvate kinase (ETH_00011145), Pyruvate kinase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86SubstrateBy similarity1
Metal bindingi88PotassiumBy similarity1
Metal bindingi90PotassiumBy similarity1
Metal bindingi121PotassiumBy similarity1
Metal bindingi122Potassium; via carbonyl oxygenBy similarity1
Sitei275Transition state stabilizerBy similarity1
Metal bindingi277MagnesiumBy similarity1
Binding sitei300Substrate; via amide nitrogenBy similarity1
Metal bindingi301MagnesiumBy similarity1
Binding sitei301Substrate; via amide nitrogenBy similarity1
Binding sitei333SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BRENDAi2.7.1.40 2046
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK
OrganismiEimeria tenella (Coccidian parasite)
Taxonomic identifieri5802 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaEimeriidaeEimeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001121001 – 531Pyruvate kinaseAdd BLAST531

Proteomic databases

PRIDEiO44006

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO44006
SMRiO44006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

O44006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPTHSQVV AAPDSSGRLL RLVSASSVMM QLLGKSTNIR MSQILEHHED
60 70 80 90 100
EDFSAHRTKI VCTMGPSCWD VDKMVQLIDA GMNVCRLNFS HGDHEAHGRV
110 120 130 140 150
VKNLQEALKQ RPGKRVALLL DTKGPEIRTG MLEGDKPIEL HAGDMLKIVT
160 170 180 190 200
DYSFVGNKSC IACSYEKLPS SVKPGNTILI ADGSLSVEVV ECGKDYVMTR
210 220 230 240 250
VMNPAIIGNK KNMNLPGVKV DLPVIGEKDK NDILNFGIPM GCNFIAASFV
260 270 280 290 300
QSADDVRYIR SILGTKGRNI KIIPKIENVE GLLNFDEILQ EADGIMIARG
310 320 330 340 350
DLGMEIPPEK VFLAQKMMIS KCNVAGKPVI TATQMLESMT KNPRPTRAEA
360 370 380 390 400
ADVANAVLDG TDCVMLSGET ANGSFPVQAV TVMSRVCFEA EGCIDYQQVF
410 420 430 440 450
RATCQATMTP IDTQEAVARA AVETAQSINA SLILALTETG RTARLIAKYR
460 470 480 490 500
PMQPILALSA SEETIKQLQV IRGVTTFLVP TFQGTDQLIR NALSAAKELQ
510 520 530
LVSEGDSIVA VHGIKEEVAG WSNLLKVLVV E
Length:531
Mass (Da):57,591
Last modified:June 1, 1998 - v1
Checksum:iC02B2399B863EE08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043910 mRNA Translation: AAC02529.1
RefSeqiXP_013232798.1, XM_013377344.1

Genome annotation databases

GeneIDi25251418

Similar proteinsi

Entry informationi

Entry nameiKPYK_EIMTE
AccessioniPrimary (citable) accession number: O44006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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