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UniProtKB - O43930 (PRKY_HUMAN)
Protein
Putative serine/threonine-protein kinase PRKY
Gene
PRKY
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay.Curated
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 78 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 172 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 55 – 63 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cAMP-dependent protein kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: ProtInc
- protein serine kinase activity Source: RHEA
GO - Biological processi
- peptidyl-serine phosphorylation Source: GO_Central
- protein phosphorylation Source: ProtInc
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O43930 |
SignaLinki | O43930 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PRKY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9444, PRKY |
MIMi | 400008, gene |
neXtProti | NX_O43930 |
VEuPathDBi | HostDB:ENSG00000099725 |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
Miscellaneous databases
Pharosi | O43930, Tdark |
Genetic variation databases
BioMutai | HGNC:9444 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086584 | 1 – 277 | Putative serine/threonine-protein kinase PRKYAdd BLAST | 277 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 203 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O43930 |
MassIVEi | O43930 |
MaxQBi | O43930 |
PeptideAtlasi | O43930 |
PRIDEi | O43930 |
ProteomicsDBi | 49242 |
PTM databases
iPTMneti | O43930 |
PhosphoSitePlusi | O43930 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
ExpressionAtlasi | O43930, baseline and differential |
Interactioni
Protein-protein interaction databases
IntActi | O43930, 3 interactors |
Miscellaneous databases
RNActi | O43930, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 277 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.Curated
Phylogenomic databases
InParanoidi | O43930 |
OMAi | YSTEIIC |
PhylomeDBi | O43930 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
O43930-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD
60 70 80 90 100
ALVTMGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV
110 120 130 140 150
LKEVSHPFLI RLFWTWHEER FLYMLMEYVP GGELFSYLRN RGHFSSTTGL
160 170 180 190 200
FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR
210 220 230 240 250
TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF
260 270
GIYQKILAGK LYFPRHLDFH VKTGRMM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 – 70 | KT → FR in CAA71508 (PubMed:9154127).Curated | 2 | |
Sequence conflicti | 88 – 90 | RKQ → NSG in CAA71509 (PubMed:9154127).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13927 , Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA Translation: CAA74244.1 Y15801 mRNA Translation: CAA75792.1 BC074851 mRNA Translation: AAH74851.1 BC074852 mRNA Translation: AAH74852.1 Y10484 mRNA Translation: CAA71508.1 Y10485 mRNA Translation: CAA71509.1 |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13927 , Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA Translation: CAA74244.1 Y15801 mRNA Translation: CAA75792.1 BC074851 mRNA Translation: AAH74851.1 BC074852 mRNA Translation: AAH74852.1 Y10484 mRNA Translation: CAA71508.1 Y10485 mRNA Translation: CAA71509.1 |
3D structure databases
SMRi | O43930 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O43930, 3 interactors |
PTM databases
iPTMneti | O43930 |
PhosphoSitePlusi | O43930 |
Genetic variation databases
BioMutai | HGNC:9444 |
Proteomic databases
jPOSTi | O43930 |
MassIVEi | O43930 |
MaxQBi | O43930 |
PeptideAtlasi | O43930 |
PRIDEi | O43930 |
ProteomicsDBi | 49242 |
Protocols and materials databases
Antibodypediai | 82234, 9 antibodies from 4 providers |
Organism-specific databases
GeneCardsi | PRKY |
HGNCi | HGNC:9444, PRKY |
MIMi | 400008, gene |
neXtProti | NX_O43930 |
VEuPathDBi | HostDB:ENSG00000099725 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | O43930 |
OMAi | YSTEIIC |
PhylomeDBi | O43930 |
Enzyme and pathway databases
PathwayCommonsi | O43930 |
SignaLinki | O43930 |
Miscellaneous databases
ChiTaRSi | PRKY, human |
Pharosi | O43930, Tdark |
PROi | PR:O43930 |
RNActi | O43930, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | O43930, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRKY_HUMAN | |
Accessioni | O43930Primary (citable) accession number: O43930 Secondary accession number(s): O15348, O15349 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families