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Protein

Putative serine/threonine-protein kinase PRKY

Gene

PRKY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78ATPPROSITE-ProRule annotation1
Active sitei172Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 63ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO43930

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein kinase PRKY (EC:2.7.11.1)
Gene namesi
Name:PRKY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9444 PRKY
MIMi400008 gene
neXtProtiNX_O43930

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Organism-specific databases

DisGeNETi5616

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865841 – 277Putative serine/threonine-protein kinase PRKYAdd BLAST277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43930
PeptideAtlasiO43930
PRIDEiO43930
ProteomicsDBi49242

PTM databases

iPTMnetiO43930
PhosphoSitePlusiO43930

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

CleanExiHS_PRKY

Interactioni

Protein-protein interaction databases

IntActiO43930, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO43930
SMRiO43930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiO43930
PhylomeDBiO43930

Family and domain databases

InterProiView protein in InterPro
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O43930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD
60 70 80 90 100
ALVTMGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV
110 120 130 140 150
LKEVSHPFLI RLFWTWHEER FLYMLMEYVP GGELFSYLRN RGHFSSTTGL
160 170 180 190 200
FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR
210 220 230 240 250
TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF
260 270
GIYQKILAGK LYFPRHLDFH VKTGRMM
Length:277
Mass (Da):31,708
Last modified:June 1, 1998 - v1
Checksum:i8DC7B21124BF8EAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69 – 70KT → FR in CAA71508 (PubMed:9154127).Curated2
Sequence conflicti88 – 90RKQ → NSG in CAA71509 (PubMed:9154127).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13927
, Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA Translation: CAA74244.1
Y15801 mRNA Translation: CAA75792.1
BC074851 mRNA Translation: AAH74851.1
BC074852 mRNA Translation: AAH74852.1
Y10484 mRNA Translation: CAA71508.1
Y10485 mRNA Translation: CAA71509.1
UniGeneiHs.584730

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13927
, Y13928, Y13929, Y13930, Y13931, Y13932 Genomic DNA Translation: CAA74244.1
Y15801 mRNA Translation: CAA75792.1
BC074851 mRNA Translation: AAH74851.1
BC074852 mRNA Translation: AAH74852.1
Y10484 mRNA Translation: CAA71508.1
Y10485 mRNA Translation: CAA71509.1
UniGeneiHs.584730

3D structure databases

ProteinModelPortaliO43930
SMRiO43930
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43930, 1 interactor

PTM databases

iPTMnetiO43930
PhosphoSitePlusiO43930

Proteomic databases

MaxQBiO43930
PeptideAtlasiO43930
PRIDEiO43930
ProteomicsDBi49242

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi5616
GeneCardsiPRKY
HGNCiHGNC:9444 PRKY
MIMi400008 gene
neXtProtiNX_O43930
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiO43930
PhylomeDBiO43930

Enzyme and pathway databases

SignaLinkiO43930

Miscellaneous databases

PROiPR:O43930
SOURCEiSearch...

Gene expression databases

CleanExiHS_PRKY

Family and domain databases

InterProiView protein in InterPro
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRKY_HUMAN
AccessioniPrimary (citable) accession number: O43930
Secondary accession number(s): O15348, O15349
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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