PRKY

Functionⁱ

Caution

Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay.Curated

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	78	ATPPROSITE-ProRule annotation		1
Active siteⁱ	172	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	55 – 63	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: ProtInc
Traceable author statementⁱ
- 9154127

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 9154127

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	O43930

SignaLinkⁱ

O43930

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative serine/threonine-protein kinase PRKY (EC:2.7.11.1)
Gene namesⁱ	Name:PRKY
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9444 PRKY
MIMⁱ	400008 gene
neXtProtⁱ	NX_O43930

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5616

DisGeNETⁱ

5616

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086584	1 – 277	Putative serine/threonine-protein kinase PRKYAdd BLAST		277

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	203	PhosphothreonineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43930
PeptideAtlas More...PeptideAtlasⁱ	O43930
PRIDEⁱ	O43930
ProteomicsDBⁱ	49242

PTM databases

iPTMnetⁱ	O43930
PhosphoSitePlusⁱ	O43930

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

CleanExⁱ	HS_PRKY

CleanExⁱ

HS_PRKY

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	O43930, 1 interactor

IntActⁱ

O43930, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43930
SMRⁱ	O43930
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 277	Protein kinasePROSITE-ProRule annotationAdd BLAST		229

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000233033
HOVERGENⁱ	HBG108317
InParanoidⁱ	O43930
PhylomeDBⁱ	O43930

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O43930-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD 
        60         70         80         90        100
ALVTMGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV 
       110        120        130        140        150
LKEVSHPFLI RLFWTWHEER FLYMLMEYVP GGELFSYLRN RGHFSSTTGL 
       160        170        180        190        200
FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR 
       210        220        230        240        250
TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF 
       260        270 
GIYQKILAGK LYFPRHLDFH VKTGRMM

Length:277

Mass (Da):31,708

Last modified:June 1, 1998 - v1

Checksum:ⁱ8DC7B21124BF8EAF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	69 – 70	KT → FR in CAA71508 (PubMed:9154127).Curated		2
Sequence conflictⁱ	88 – 90	RKQ → NSG in CAA71509 (PubMed:9154127).Curated		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y13927 Y13932 Genomic DNA Translation: CAA74244.1 Y15801 mRNA Translation: CAA75792.1 BC074851 mRNA Translation: AAH74851.1 BC074852 mRNA Translation: AAH74852.1 Y10484 mRNA Translation: CAA71508.1 Y10485 mRNA Translation: CAA71509.1
UniGeneⁱ	Hs.584730

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Protein	Similar proteins		Species	Score	Length	Source
O43930	Protein kinase, Y-linked, isoform CRA_a		HUMAN		277	UniRef100_O43930

Protein	Similar proteins		Species	Score	Length	Source
O43930	Protein kinase, Y-linked, isoform CRA_a		HUMAN		277	UniRef90_O43930
Uncharacterized protein		PANTR		337
Protein kinase Y-linked		western gorilla		277

Protein	Similar proteins		Species	Score	Length	Source
O43930	Protein kinase, Y-linked, isoform CRA_a		HUMAN		277	UniRef50_O43930
Uncharacterized protein		PANTR		337
Protein kinase Y-linked		western gorilla		277
Uncharacterized protein		MACFA		332
Uncharacterized protein		CERAT		332
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y13927 Y13932 Genomic DNA Translation: CAA74244.1 Y15801 mRNA Translation: CAA75792.1 BC074851 mRNA Translation: AAH74851.1 BC074852 mRNA Translation: AAH74852.1 Y10484 mRNA Translation: CAA71508.1 Y10485 mRNA Translation: CAA71509.1
UniGeneⁱ	Hs.584730

3D structure databases

ProteinModelPortalⁱ	O43930
SMRⁱ	O43930
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O43930, 1 interactor

IntActⁱ

O43930, 1 interactor

PTM databases

iPTMnetⁱ	O43930
PhosphoSitePlusⁱ	O43930

Proteomic databases

MaxQBⁱ	O43930
PeptideAtlasⁱ	O43930
PRIDEⁱ	O43930
ProteomicsDBⁱ	49242

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

DisGeNETⁱ	5616
GeneCardsⁱ	PRKY
HGNCⁱ	HGNC:9444 PRKY
MIMⁱ	400008 gene
neXtProtⁱ	NX_O43930
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOGENOMⁱ	HOG000233033
HOVERGENⁱ	HBG108317
InParanoidⁱ	O43930
PhylomeDBⁱ	O43930

Enzyme and pathway databases

SignaLinkⁱ	O43930

SignaLinkⁱ

O43930

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O43930
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	HS_PRKY

CleanExⁱ

HS_PRKY

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRKY_HUMAN
Accessionⁱ	O43930Primary (citable) accession number: O43930 Secondary accession number(s): O15348, O15349
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	June 1, 1998
	Last modified:	June 20, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43930 (PRKY_HUMAN)

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Putative serine/threonine-protein kinase PRKY

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ