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Protein

Origin recognition complex subunit 4

Gene

ORC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi67 – 74ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA replication origin binding Source: UniProtKB
  • nucleotide binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-68616 Assembly of the ORC complex at the origin of replication
R-HSA-68689 CDC6 association with the ORC:origin complex
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Origin recognition complex subunit 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORC4
Synonyms:ORC4L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000115947.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8490 ORC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603056 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43929

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Meier-Gorlin syndrome 2 (MGORS2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
See also OMIM:613800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065486174Y → C in MGORS2. 2 PublicationsCorresponds to variant dbSNP:rs387906847EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi73K → A or E: Impairs ORC complex formation. 1 Publication1
Mutagenesisi159 – 160DE → AA: Impairs ORC complex formation. 1 Publication2

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
5000

MalaCards human disease database

More...
MalaCardsi
ORC4
MIMi613800 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115947

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2554 Ear-patella-short stature syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32811

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ORC4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001270871 – 436Origin recognition complex subunit 4Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7N6-methyllysineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43929

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43929

MaxQB - The MaxQuant DataBase

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MaxQBi
O43929

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43929

PeptideAtlas

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PeptideAtlasi
O43929

PRoteomics IDEntifications database

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PRIDEi
O43929

ProteomicsDB human proteome resource

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ProteomicsDBi
49241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43929

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43929

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115947 Expressed in 222 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

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CleanExi
HS_ORC4L

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43929 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43929 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015124
HPA064562

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with POLQ (PubMed:24989122).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111042, 54 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1880 Nuclear origin of replication recognition complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O43929

Database of interacting proteins

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DIPi
DIP-29690N

Protein interaction database and analysis system

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IntActi
O43929, 36 interactors

Molecular INTeraction database

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MINTi
O43929

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264169

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1436
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UJ7X-ray3.39C/D1-436[»]
5UJMelectron microscopy18.00D1-436[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43929

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43929

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ORC4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2228 Eukaryota
ENOG410XSK0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000016542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007226

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000253

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43929

KEGG Orthology (KO)

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KOi
K02606

Identification of Orthologs from Complete Genome Data

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OMAi
FQKFIQR

Database of Orthologous Groups

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OrthoDBi
1057372at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43929

TreeFam database of animal gene trees

More...
TreeFami
TF101094

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR016527 ORC4
IPR032705 ORC4_C
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR12087 PTHR12087, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14629 ORC4_C, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF007858 ORC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43929-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL
60 70 80 90 100
LKRTALHGES NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN
110 120 130 140 150
GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS
160 170 180 190 200
SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE
210 220 230 240 250
LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN
260 270 280 290 300
ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV
310 320 330 340 350
DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY
360 370 380 390 400
NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ
410 420 430
LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL
Length:436
Mass (Da):50,377
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7020B6690E30B4E
GO
Isoform 2 (identifier: O43929-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):40,870
Checksum:iEE1B23556EB4AA9E
GO
Isoform 3 (identifier: O43929-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):42,034
Checksum:iFB95A4CFA5AB1CB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53SE3Q53SE3_HUMAN
Origin recognition complex subunit ...
ORC4 ORC4L
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2X8C9J2X8_HUMAN
Origin recognition complex subunit ...
ORC4
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGH7C9JGH7_HUMAN
Origin recognition complex subunit ...
ORC4
127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135N → S in BAH12887 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01452356L → V1 PublicationCorresponds to variant dbSNP:rs2307397EnsemblClinVar.1
Natural variantiVAR_01923578N → S4 PublicationsCorresponds to variant dbSNP:rs2307394EnsemblClinVar.1
Natural variantiVAR_065486174Y → C in MGORS2. 2 PublicationsCorresponds to variant dbSNP:rs387906847EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451991 – 84Missing in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_0464371 – 74Missing in isoform 3. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF022108 mRNA Translation: AAC01957.1
AF047598 mRNA Translation: AAC80282.1
AF132596 mRNA Translation: AAD22110.1
AY600302 Genomic DNA Translation: AAS94326.1
AK295721 mRNA Translation: BAH12166.1
AK298862 mRNA Translation: BAH12887.1
AC009480 Genomic DNA No translation available.
AC019226 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11555.1
CH471058 Genomic DNA Translation: EAX11556.1
CH471058 Genomic DNA Translation: EAX11557.1
CH471058 Genomic DNA Translation: EAX11558.1
BC014847 mRNA Translation: AAH14847.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2187.1 [O43929-1]
CCDS54404.1 [O43929-2]
CCDS54405.1 [O43929-3]

NCBI Reference Sequences

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RefSeqi
NP_001177808.1, NM_001190879.2 [O43929-1]
NP_001177810.1, NM_001190881.2 [O43929-2]
NP_001177811.1, NM_001190882.2 [O43929-3]
NP_002543.2, NM_002552.4 [O43929-1]
NP_859525.1, NM_181741.3 [O43929-1]
NP_859526.1, NM_181742.3 [O43929-1]
XP_011509557.1, XM_011511255.2 [O43929-1]
XP_016859715.1, XM_017004226.1 [O43929-1]
XP_016859716.1, XM_017004227.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.558364

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264169; ENSP00000264169; ENSG00000115947 [O43929-1]
ENST00000392857; ENSP00000376597; ENSG00000115947 [O43929-1]
ENST00000535373; ENSP00000441953; ENSG00000115947 [O43929-1]
ENST00000536575; ENSP00000441502; ENSG00000115947 [O43929-2]
ENST00000540442; ENSP00000438326; ENSG00000115947 [O43929-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5000

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5000

UCSC genome browser

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UCSCi
uc002twi.4 human [O43929-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022108 mRNA Translation: AAC01957.1
AF047598 mRNA Translation: AAC80282.1
AF132596 mRNA Translation: AAD22110.1
AY600302 Genomic DNA Translation: AAS94326.1
AK295721 mRNA Translation: BAH12166.1
AK298862 mRNA Translation: BAH12887.1
AC009480 Genomic DNA No translation available.
AC019226 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11555.1
CH471058 Genomic DNA Translation: EAX11556.1
CH471058 Genomic DNA Translation: EAX11557.1
CH471058 Genomic DNA Translation: EAX11558.1
BC014847 mRNA Translation: AAH14847.1
CCDSiCCDS2187.1 [O43929-1]
CCDS54404.1 [O43929-2]
CCDS54405.1 [O43929-3]
RefSeqiNP_001177808.1, NM_001190879.2 [O43929-1]
NP_001177810.1, NM_001190881.2 [O43929-2]
NP_001177811.1, NM_001190882.2 [O43929-3]
NP_002543.2, NM_002552.4 [O43929-1]
NP_859525.1, NM_181741.3 [O43929-1]
NP_859526.1, NM_181742.3 [O43929-1]
XP_011509557.1, XM_011511255.2 [O43929-1]
XP_016859715.1, XM_017004226.1 [O43929-1]
XP_016859716.1, XM_017004227.1
UniGeneiHs.558364

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UJ7X-ray3.39C/D1-436[»]
5UJMelectron microscopy18.00D1-436[»]
ProteinModelPortaliO43929
SMRiO43929
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111042, 54 interactors
ComplexPortaliCPX-1880 Nuclear origin of replication recognition complex
CORUMiO43929
DIPiDIP-29690N
IntActiO43929, 36 interactors
MINTiO43929
STRINGi9606.ENSP00000264169

PTM databases

iPTMnetiO43929
PhosphoSitePlusiO43929

Polymorphism and mutation databases

BioMutaiORC4

Proteomic databases

EPDiO43929
jPOSTiO43929
MaxQBiO43929
PaxDbiO43929
PeptideAtlasiO43929
PRIDEiO43929
ProteomicsDBi49241

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5000
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264169; ENSP00000264169; ENSG00000115947 [O43929-1]
ENST00000392857; ENSP00000376597; ENSG00000115947 [O43929-1]
ENST00000535373; ENSP00000441953; ENSG00000115947 [O43929-1]
ENST00000536575; ENSP00000441502; ENSG00000115947 [O43929-2]
ENST00000540442; ENSP00000438326; ENSG00000115947 [O43929-3]
GeneIDi5000
KEGGihsa:5000
UCSCiuc002twi.4 human [O43929-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5000
DisGeNETi5000
EuPathDBiHostDB:ENSG00000115947.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ORC4
HGNCiHGNC:8490 ORC4
HPAiCAB015124
HPA064562
MalaCardsiORC4
MIMi603056 gene
613800 phenotype
neXtProtiNX_O43929
OpenTargetsiENSG00000115947
Orphaneti2554 Ear-patella-short stature syndrome
PharmGKBiPA32811

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2228 Eukaryota
ENOG410XSK0 LUCA
GeneTreeiENSGT00390000016542
HOGENOMiHOG000007226
HOVERGENiHBG000253
InParanoidiO43929
KOiK02606
OMAiFQKFIQR
OrthoDBi1057372at2759
PhylomeDBiO43929
TreeFamiTF101094

Enzyme and pathway databases

ReactomeiR-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-68616 Assembly of the ORC complex at the origin of replication
R-HSA-68689 CDC6 association with the ORC:origin complex
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ORC4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ORC4
ORC4L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5000

Protein Ontology

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PROi
PR:O43929

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115947 Expressed in 222 organ(s), highest expression level in kidney
CleanExiHS_ORC4L
ExpressionAtlasiO43929 baseline and differential
GenevisibleiO43929 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR016527 ORC4
IPR032705 ORC4_C
IPR027417 P-loop_NTPase
PANTHERiPTHR12087 PTHR12087, 1 hit
PfamiView protein in Pfam
PF14629 ORC4_C, 1 hit
PIRSFiPIRSF007858 ORC4, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiORC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43929
Secondary accession number(s): B7Z3D0
, B7Z5F1, D3DP86, F5H069, Q96C42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2005
Last modified: January 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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