Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C motif chemokine 13

Gene

CXCL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
Angie
B cell-attracting chemokine 1
Short name:
BCA-1
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:CXCL13
Synonyms:BCA1, BLC, SCYB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000156234.7
HGNCiHGNC:10639 CXCL13
MIMi605149 gene
neXtProtiNX_O43927

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10563
OpenTargetsiENSG00000156234
PharmGKBiPA35570

Polymorphism and mutation databases

BioMutaiCXCL13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000511323 – 109C-X-C motif chemokine 13Add BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi35 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO43927
PeptideAtlasiO43927
PRIDEiO43927
ProteomicsDBi49240

PTM databases

iPTMnetiO43927
PhosphoSitePlusiO43927

Expressioni

Tissue specificityi

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Gene expression databases

BgeeiENSG00000156234 Expressed in 139 organ(s), highest expression level in tonsil
CleanExiHS_CXCL13
ExpressionAtlasiO43927 baseline and differential
GenevisibleiO43927 HS

Organism-specific databases

HPAiHPA052613

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115814, 4 interactors
DIPiDIP-5914N
IntActiO43927, 9 interactors
MINTiO43927
STRINGi9606.ENSP00000286758

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43927
SMRiO43927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN1 Eukaryota
ENOG4111E5H LUCA
GeneTreeiENSGT00530000064292
HOGENOMiHOG000220915
HOVERGENiHBG098474
InParanoidiO43927
KOiK10032
OMAiCPRKEII
OrthoDBiEOG091G0XS0
PhylomeDBiO43927
TreeFamiTF335204

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR
60 70 80 90 100
IQILPRGNGC PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP

VPVFKRKIP
Length:109
Mass (Da):12,664
Last modified:June 1, 1998 - v1
Checksum:i4057FCA8EFF658A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA Translation: AAC14402.1
AJ002211 mRNA Translation: CAA05250.1
AF029894 mRNA Translation: AAC17980.1
BC012589 mRNA Translation: AAH12589.1
CCDSiCCDS3582.1
RefSeqiNP_006410.1, NM_006419.2
XP_006714126.1, XM_006714063.3
UniGeneiHs.100431

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234
GeneIDi10563
KEGGihsa:10563

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA Translation: AAC14402.1
AJ002211 mRNA Translation: CAA05250.1
AF029894 mRNA Translation: AAC17980.1
BC012589 mRNA Translation: AAH12589.1
CCDSiCCDS3582.1
RefSeqiNP_006410.1, NM_006419.2
XP_006714126.1, XM_006714063.3
UniGeneiHs.100431

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZAIX-ray1.95A23-109[»]
5CBAX-ray2.50E/F23-109[»]
5CBEX-ray2.40E/F23-109[»]
ProteinModelPortaliO43927
SMRiO43927
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115814, 4 interactors
DIPiDIP-5914N
IntActiO43927, 9 interactors
MINTiO43927
STRINGi9606.ENSP00000286758

PTM databases

iPTMnetiO43927
PhosphoSitePlusiO43927

Polymorphism and mutation databases

BioMutaiCXCL13

Proteomic databases

PaxDbiO43927
PeptideAtlasiO43927
PRIDEiO43927
ProteomicsDBi49240

Protocols and materials databases

DNASUi10563
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234
GeneIDi10563
KEGGihsa:10563

Organism-specific databases

CTDi10563
DisGeNETi10563
EuPathDBiHostDB:ENSG00000156234.7
GeneCardsiCXCL13
HGNCiHGNC:10639 CXCL13
HPAiHPA052613
MIMi605149 gene
neXtProtiNX_O43927
OpenTargetsiENSG00000156234
PharmGKBiPA35570
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEN1 Eukaryota
ENOG4111E5H LUCA
GeneTreeiENSGT00530000064292
HOGENOMiHOG000220915
HOVERGENiHBG098474
InParanoidiO43927
KOiK10032
OMAiCPRKEII
OrthoDBiEOG091G0XS0
PhylomeDBiO43927
TreeFamiTF335204

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiCXCL13 human
GeneWikiiCXCL13
GenomeRNAii10563
PROiPR:O43927
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156234 Expressed in 139 organ(s), highest expression level in tonsil
CleanExiHS_CXCL13
ExpressionAtlasiO43927 baseline and differential
GenevisibleiO43927 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXL13_HUMAN
AccessioniPrimary (citable) accession number: O43927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again