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Protein

C-X-C motif chemokine 13

Gene

CXCL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: BHF-UCL
  • CXCR3 chemokine receptor binding Source: BHF-UCL
  • CXCR5 chemokine receptor binding Source: BHF-UCL
  • fibroblast growth factor binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • receptor ligand activity Source: BHF-UCL

GO - Biological processi

  • activation of GTPase activity Source: BHF-UCL
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • B cell chemotaxis Source: BHF-UCL
  • cell-cell signaling Source: BHF-UCL
  • cell surface receptor signaling pathway Source: BHF-UCL
  • chemokine-mediated signaling pathway Source: GO_Central
  • chronic inflammatory response Source: BHF-UCL
  • defense response to bacterium Source: BHF-UCL
  • endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  • germinal center formation Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • killing of cells of other organism Source: UniProtKB
  • lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  • negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  • positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of integrin activation Source: BHF-UCL
  • positive regulation of T cell chemotaxis Source: BHF-UCL
  • regulation of angiogenesis Source: BHF-UCL
  • regulation of cell proliferation Source: GO_Central
  • regulation of humoral immune response Source: BHF-UCL
  • response to lipopolysaccharide Source: GO_Central

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
Angie
B cell-attracting chemokine 1
Short name:
BCA-1
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:CXCL13
Synonyms:BCA1, BLC, SCYB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000156234.7
HGNCiHGNC:10639 CXCL13
MIMi605149 gene
neXtProtiNX_O43927

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10563
OpenTargetsiENSG00000156234
PharmGKBiPA35570

Polymorphism and mutation databases

BioMutaiCXCL13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000511323 – 109C-X-C motif chemokine 13Add BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi35 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO43927
PeptideAtlasiO43927
PRIDEiO43927
ProteomicsDBi49240

PTM databases

iPTMnetiO43927
PhosphoSitePlusiO43927

Expressioni

Tissue specificityi

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Gene expression databases

BgeeiENSG00000156234
CleanExiHS_CXCL13
ExpressionAtlasiO43927 baseline and differential
GenevisibleiO43927 HS

Organism-specific databases

HPAiHPA052613

Interactioni

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: BHF-UCL
  • CXCR3 chemokine receptor binding Source: BHF-UCL
  • CXCR5 chemokine receptor binding Source: BHF-UCL
  • fibroblast growth factor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • receptor ligand activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi115814, 4 interactors
DIPiDIP-5914N
IntActiO43927, 5 interactors
MINTiO43927
STRINGi9606.ENSP00000286758

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 26Combined sources4
Beta strandi35 – 37Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 54Combined sources7
Beta strandi60 – 62Combined sources3
Beta strandi64 – 69Combined sources6
Beta strandi74 – 77Combined sources4
Helixi82 – 93Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZAIX-ray1.95A23-109[»]
5CBAX-ray2.50E/F23-109[»]
5CBEX-ray2.40E/F23-109[»]
ProteinModelPortaliO43927
SMRiO43927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN1 Eukaryota
ENOG4111E5H LUCA
GeneTreeiENSGT00530000064292
HOGENOMiHOG000220915
HOVERGENiHBG098474
InParanoidiO43927
KOiK10032
OMAiCPRKEII
OrthoDBiEOG091G0XS0
PhylomeDBiO43927
TreeFamiTF335204

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR
60 70 80 90 100
IQILPRGNGC PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP

VPVFKRKIP
Length:109
Mass (Da):12,664
Last modified:June 1, 1998 - v1
Checksum:i4057FCA8EFF658A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044197 mRNA Translation: AAC14402.1
AJ002211 mRNA Translation: CAA05250.1
AF029894 mRNA Translation: AAC17980.1
BC012589 mRNA Translation: AAH12589.1
CCDSiCCDS3582.1
RefSeqiNP_006410.1, NM_006419.2
XP_006714126.1, XM_006714063.3
UniGeneiHs.100431

Genome annotation databases

EnsembliENST00000286758; ENSP00000286758; ENSG00000156234
GeneIDi10563
KEGGihsa:10563

Similar proteinsi

Entry informationi

Entry nameiCXL13_HUMAN
AccessioniPrimary (citable) accession number: O43927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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