Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ephrin-A2

Gene

EFNA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).By similarity

GO - Molecular functioni

  • ephrin receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
SignaLinkiO43921
SIGNORiO43921

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A2
Alternative name(s):
EPH-related receptor tyrosine kinase ligand 6
Short name:
LERK-6
HEK7 ligand
Short name:
HEK7-L
Gene namesi
Name:EFNA2
Synonyms:EPLG6, LERK6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099617.3
HGNCiHGNC:3222 EFNA2
MIMi602756 gene
neXtProtiNX_O43921

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1943
OpenTargetsiENSG00000099617
PharmGKBiPA27657

Chemistry databases

ChEMBLiCHEMBL1795109

Polymorphism and mutation databases

BioMutaiEFNA2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000836125 – 188Ephrin-A2Add BLAST164
PropeptideiPRO_0000008362189 – 213Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 114PROSITE-ProRule annotation1 Publication
Disulfide bondi102 ↔ 163PROSITE-ProRule annotation1 Publication
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi188GPI-anchor amidated asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO43921
PeptideAtlasiO43921
PRIDEiO43921
ProteomicsDBi49238

PTM databases

iPTMnetiO43921
PhosphoSitePlusiO43921

Miscellaneous databases

PMAP-CutDBiO43921

Expressioni

Gene expression databases

BgeeiENSG00000099617 Expressed in 48 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_EFNA2
GenevisibleiO43921 HS

Organism-specific databases

HPAiCAB005178
HPA067567

Interactioni

Subunit structurei

Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EPHA4P547644EBI-8603210,EBI-5773557

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108263, 4 interactors
DIPiDIP-48293N
IntActiO43921, 3 interactors
MINTiO43921
STRINGi9606.ENSP00000215368

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43921
SMRiO43921
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43921

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 174Ephrin RBDPROSITE-ProRule annotationAdd BLAST141

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiO43921
KOiK05462
OMAiSDRYAVY
OrthoDBiEOG091G0LOO
PhylomeDBiO43921

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAQRPLLP LLLLLLPLPP PPFARAEDAA RANSDRYAVY WNRSNPRFHA
60 70 80 90 100
GAGDDGGGYT VEVSINDYLD IYCPHYGAPL PPAERMEHYV LYMVNGEGHA
110 120 130 140 150
SCDHRQRGFK RWECNRPAAP GGPLKFSEKF QLFTPFSLGF EFRPGHEYYY
160 170 180 190 200
ISATPPNAVD RPCLRLKVYV RPTNETLYEA PEPIFTSNNS CSSPGGCRLF
210
LSTIPVLWTL LGS
Length:213
Mass (Da):23,878
Last modified:June 1, 1998 - v1
Checksum:i33C9FB1A8168B2D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6R → A in CAA07435 (PubMed:9826538).Curated1
Sequence conflicti25 – 26RA → PP in CAA07435 (PubMed:9826538).Curated2
Sequence conflicti29 – 30AA → RR in CAA07435 (PubMed:9826538).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92896, U92893, U92894 Genomic DNA Translation: AAC39577.1
AJ007292 mRNA Translation: CAA07435.1
AC004258 Genomic DNA Translation: AAC04896.1
CCDSiCCDS12061.1
PIRiJE0322
RefSeqiNP_001396.2, NM_001405.3
UniGeneiHs.741510

Genome annotation databases

EnsembliENST00000215368; ENSP00000215368; ENSG00000099617
GeneIDi1943
KEGGihsa:1943
UCSCiuc002lry.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92896, U92893, U92894 Genomic DNA Translation: AAC39577.1
AJ007292 mRNA Translation: CAA07435.1
AC004258 Genomic DNA Translation: AAC04896.1
CCDSiCCDS12061.1
PIRiJE0322
RefSeqiNP_001396.2, NM_001405.3
UniGeneiHs.741510

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WO3X-ray2.35B33-173[»]
ProteinModelPortaliO43921
SMRiO43921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108263, 4 interactors
DIPiDIP-48293N
IntActiO43921, 3 interactors
MINTiO43921
STRINGi9606.ENSP00000215368

Chemistry databases

ChEMBLiCHEMBL1795109

PTM databases

iPTMnetiO43921
PhosphoSitePlusiO43921

Polymorphism and mutation databases

BioMutaiEFNA2

Proteomic databases

PaxDbiO43921
PeptideAtlasiO43921
PRIDEiO43921
ProteomicsDBi49238

Protocols and materials databases

DNASUi1943
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215368; ENSP00000215368; ENSG00000099617
GeneIDi1943
KEGGihsa:1943
UCSCiuc002lry.3 human

Organism-specific databases

CTDi1943
DisGeNETi1943
EuPathDBiHostDB:ENSG00000099617.3
GeneCardsiEFNA2
HGNCiHGNC:3222 EFNA2
HPAiCAB005178
HPA067567
MIMi602756 gene
neXtProtiNX_O43921
OpenTargetsiENSG00000099617
PharmGKBiPA27657
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiO43921
KOiK05462
OMAiSDRYAVY
OrthoDBiEOG091G0LOO
PhylomeDBiO43921

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
SignaLinkiO43921
SIGNORiO43921

Miscellaneous databases

ChiTaRSiEFNA2 human
EvolutionaryTraceiO43921
GeneWikiiEFNA2
GenomeRNAii1943
PMAP-CutDBiO43921
PROiPR:O43921
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099617 Expressed in 48 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_EFNA2
GenevisibleiO43921 HS

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFNA2_HUMAN
AccessioniPrimary (citable) accession number: O43921
Secondary accession number(s): O76020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again