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Protein

Vascular endothelial growth factor D

Gene

VEGFD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.1 Publication

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • growth factor activity Source: GO_Central
  • platelet-derived growth factor receptor binding Source: ProtInc
  • protein homodimerization activity Source: Ensembl
  • vascular endothelial growth factor receptor 3 binding Source: GO_Central
  • vascular endothelial growth factor receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

BRENDAi3.4.21.46 2681
ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-194313 VEGF ligand-receptor interactions
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
SIGNORiO43915

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor DImported
Short name:
VEGF-D
Alternative name(s):
c-Fos-induced growth factor
Short name:
FIGF
Gene namesi
Name:VEGFDImported
Synonyms:FIGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000165197.4
HGNCiHGNC:3708 VEGFD
MIMi300091 gene
neXtProtiNX_O43915

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2277
OpenTargetsiENSG00000165197
PharmGKBiPA28146

Polymorphism and mutation databases

BioMutaiFIGF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002340822 – 88Or 99 (in a minor form)1 PublicationAdd BLAST67
ChainiPRO_000002340989 – 205Vascular endothelial growth factor DAdd BLAST117
PropeptideiPRO_0000023410206 – 354Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi111 ↔ 1531 Publication
Disulfide bondi136Interchain1 Publication
Disulfide bondi142 ↔ 1891 Publication
Disulfide bondi145Interchain1 Publication
Disulfide bondi146 ↔ 1911 Publication
Glycosylationi155N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi185N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43915
PeptideAtlasiO43915
PRIDEiO43915
ProteomicsDBi49231

PTM databases

iPTMnetiO43915
PhosphoSitePlusiO43915

Expressioni

Tissue specificityi

Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.

Gene expression databases

BgeeiENSG00000165197
CleanExiHS_FIGF
GenevisibleiO43915 HS

Organism-specific databases

HPAiHPA027342

Interactioni

Subunit structurei

Homodimer; non-covalent and antiparallel.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VAMP3Q158364EBI-11750035,EBI-722343

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • growth factor activity Source: GO_Central
  • platelet-derived growth factor receptor binding Source: ProtInc
  • protein homodimerization activity Source: Ensembl
  • vascular endothelial growth factor receptor 3 binding Source: GO_Central
  • vascular endothelial growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108567, 12 interactors
CORUMiO43915
IntActiO43915, 1 interactor
STRINGi9606.ENSP00000297904

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi93 – 108Combined sources16
Beta strandi110 – 119Combined sources10
Helixi120 – 123Combined sources4
Helixi127 – 129Combined sources3
Beta strandi133 – 143Combined sources11
Beta strandi152 – 166Combined sources15
Beta strandi169 – 171Combined sources3
Beta strandi178 – 192Combined sources15

3D structure databases

ProteinModelPortaliO43915
SMRiO43915
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43915

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati222 – 2371; approximateAdd BLAST16
Repeati258 – 2732Add BLAST16
Repeati277 – 2933Add BLAST17
Repeati301 – 3184Add BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 3184 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd BLAST97

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVDX Eukaryota
ENOG4111ICH LUCA
GeneTreeiENSGT00730000110889
HOGENOMiHOG000231512
HOVERGENiHBG073119
InParanoidiO43915
KOiK05449
OMAiCEDRCPF
OrthoDBiEOG091G07BT
PhylomeDBiO43915
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYREWVVVNV FMMLYVQLVQ GSSNEHGPVK RSSQSTLERS EQQIRAASSL
60 70 80 90 100
EELLRITHSE DWKLWRCRLR LKSFTSMDSR SASHRSTRFA ATFYDIETLK
110 120 130 140 150
VIDEEWQRTQ CSPRETCVEV ASELGKSTNT FFKPPCVNVF RCGGCCNEES
160 170 180 190 200
LICMNTSTSY ISKQLFEISV PLTSVPELVP VKVANHTGCK CLPTAPRHPY
210 220 230 240 250
SIIRRSIQIP EEDRCSHSKK LCPIDMLWDS NKCKCVLQEE NPLAGTEDHS
260 270 280 290 300
HLQEPALCGP HMMFDEDRCE CVCKTPCPKD LIQHPKNCSC FECKESLETC
310 320 330 340 350
CQKHKLFHPD TCSCEDRCPF HTRPCASGKT ACAKHCRFPK EKRAAQGPHS

RKNP
Length:354
Mass (Da):40,444
Last modified:June 1, 1998 - v1
Checksum:i2048D769D735173E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89630 mRNA Translation: BAA24264.1
Y12863 mRNA Translation: CAA73370.1
Y12864
, Y12865, Y12866, Y12867, Y12868, Y12869, Y12870 Genomic DNA Translation: CAA73371.1
AJ000185 mRNA Translation: CAA03942.1
AK313173 mRNA Translation: BAG35990.1
CH471074 Genomic DNA Translation: EAW98885.1
BC027948 mRNA Translation: AAH27948.1
CCDSiCCDS14166.1
RefSeqiNP_004460.1, NM_004469.4
UniGeneiHs.11392

Genome annotation databases

EnsembliENST00000297904; ENSP00000297904; ENSG00000165197
GeneIDi2277
KEGGihsa:2277
UCSCiuc004cwt.3 human

Similar proteinsi

Entry informationi

Entry nameiVEGFD_HUMAN
AccessioniPrimary (citable) accession number: O43915
Secondary accession number(s): B2R7Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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