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Protein

NKG2-F type II integral membrane protein

Gene

KLRC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

GO - Biological processi

  • cellular defense response Source: ProtInc

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2-F type II integral membrane protein
Alternative name(s):
NK cell receptor F
NKG2-F-activating NK receptor
Gene namesi
Name:KLRC4
Synonyms:NKG2F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000183542.5
HGNCiHGNC:6377 KLRC4
MIMi602893 gene
neXtProtiNX_O43908

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini96 – 158ExtracellularSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8302
MalaCardsiKLRC4
OpenTargetsiENSG00000183542
Orphaneti117 Behcet disease
PharmGKBiPA30166

Polymorphism and mutation databases

BioMutaiKLRC4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466731 – 158NKG2-F type II integral membrane proteinAdd BLAST158

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO43908
PRIDEiO43908
ProteomicsDBi49225

PTM databases

iPTMnetiO43908
PhosphoSitePlusiO43908

Expressioni

Tissue specificityi

Natural killer cells.

Gene expression databases

BgeeiENSG00000183542 Expressed in 79 organ(s), highest expression level in corpus callosum
GenevisibleiO43908 HS

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with CD94.

Protein-protein interaction databases

BioGridi113903, 38 interactors
STRINGi9606.ENSP00000310216

Structurei

3D structure databases

ProteinModelPortaliO43908
SMRiO43908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KGBU Eukaryota
ENOG4110SFD LUCA
GeneTreeiENSGT00730000110282
HOGENOMiHOG000220925
HOVERGENiHBG077044
InParanoidiO43908
KOiK06541
OMAiGHCPEES
OrthoDBiEOG091G0I60
PhylomeDBiO43908

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
SUPFAMiSSF56436 SSF56436, 1 hit

Sequencei

Sequence statusi: Complete.

O43908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS
60 70 80 90 100
DHQGNDKTYH CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL
110 120 130 140 150
EQNNFSLNRR MQKARHCGHC PEEWITYSNS CYYIGKERRT WEERVCWPVL

RRTLICFL
Length:158
Mass (Da):18,234
Last modified:January 11, 2011 - v2
Checksum:i1AABC0E5ED26ACCC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01340629I → S in allele NKG2-F*02. 4 PublicationsCorresponds to variant dbSNP:rs1841958Ensembl.1
Natural variantiVAR_013407104N → S in allele NKG2-F*02. 4 PublicationsCorresponds to variant dbSNP:rs2617170Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96846 Genomic DNA Translation: AAC51910.1
U96845 mRNA Translation: AAC51909.1
AF027164 Genomic DNA Translation: AAC17491.1
AJ001683 mRNA Translation: CAA04921.1
AJ001686 Genomic DNA Translation: CAA04924.1
AF350018 mRNA Translation: AAK83805.1
AF350019 mRNA Translation: AAK83806.1
AC022075 Genomic DNA No translation available.
BC017784 mRNA Translation: AAH17784.1
CCDSiCCDS8624.1
RefSeqiNP_038459.1, NM_013431.2
UniGeneiHs.721094

Genome annotation databases

EnsembliENST00000309384; ENSP00000310216; ENSG00000183542
GeneIDi8302
KEGGihsa:8302
UCSCiuc001qye.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96846 Genomic DNA Translation: AAC51910.1
U96845 mRNA Translation: AAC51909.1
AF027164 Genomic DNA Translation: AAC17491.1
AJ001683 mRNA Translation: CAA04921.1
AJ001686 Genomic DNA Translation: CAA04924.1
AF350018 mRNA Translation: AAK83805.1
AF350019 mRNA Translation: AAK83806.1
AC022075 Genomic DNA No translation available.
BC017784 mRNA Translation: AAH17784.1
CCDSiCCDS8624.1
RefSeqiNP_038459.1, NM_013431.2
UniGeneiHs.721094

3D structure databases

ProteinModelPortaliO43908
SMRiO43908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113903, 38 interactors
STRINGi9606.ENSP00000310216

PTM databases

iPTMnetiO43908
PhosphoSitePlusiO43908

Polymorphism and mutation databases

BioMutaiKLRC4

Proteomic databases

PaxDbiO43908
PRIDEiO43908
ProteomicsDBi49225

Protocols and materials databases

DNASUi8302
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309384; ENSP00000310216; ENSG00000183542
GeneIDi8302
KEGGihsa:8302
UCSCiuc001qye.4 human

Organism-specific databases

CTDi8302
DisGeNETi8302
EuPathDBiHostDB:ENSG00000183542.5
GeneCardsiKLRC4
HGNCiHGNC:6377 KLRC4
MalaCardsiKLRC4
MIMi602893 gene
neXtProtiNX_O43908
OpenTargetsiENSG00000183542
Orphaneti117 Behcet disease
PharmGKBiPA30166
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KGBU Eukaryota
ENOG4110SFD LUCA
GeneTreeiENSGT00730000110282
HOGENOMiHOG000220925
HOVERGENiHBG077044
InParanoidiO43908
KOiK06541
OMAiGHCPEES
OrthoDBiEOG091G0I60
PhylomeDBiO43908

Miscellaneous databases

GeneWikiiKLRC4
GenomeRNAii8302
PROiPR:O43908
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183542 Expressed in 79 organ(s), highest expression level in corpus callosum
GenevisibleiO43908 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
SUPFAMiSSF56436 SSF56436, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKG2F_HUMAN
AccessioniPrimary (citable) accession number: O43908
Secondary accession number(s): O60851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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