Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth arrest-specific protein 2

Gene

GAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle, Cell shape, Growth arrest

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
SIGNORiO43903

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 2
Short name:
GAS-2
Gene namesi
Name:GAS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000148935.10
HGNCiHGNC:4167 GAS2
MIMi602835 gene
neXtProtiNX_O43903

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2620
OpenTargetsiENSG00000148935
PharmGKBiPA28580

Polymorphism and mutation databases

BioMutaiGAS2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904401 – 313Growth arrest-specific protein 2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineBy similarity1
Modified residuei187PhosphoserineCombined sources1

Post-translational modificationi

Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei278 – 279Cleavage; by a caspase during apoptosis2

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43903
PaxDbiO43903
PeptideAtlasiO43903
PRIDEiO43903
ProteomicsDBi49224

PTM databases

iPTMnetiO43903
PhosphoSitePlusiO43903

Miscellaneous databases

PMAP-CutDBiO43903

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.

Developmental stagei

Specifically expressed at growth arrest.

Gene expression databases

BgeeiENSG00000148935 Expressed in 174 organ(s), highest expression level in liver
CleanExiHS_GAS2
ExpressionAtlasiO43903 baseline and differential
GenevisibleiO43903 HS

Organism-specific databases

HPAiHPA058904

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108890, 2 interactors
IntActiO43903, 1 interactor
STRINGi9606.ENSP00000278187

Structurei

3D structure databases

ProteinModelPortaliO43903
SMRiO43903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 156Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST123
Domaini197 – 270GARPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the GAS2 family.Curated

Phylogenomic databases

eggNOGiENOG410IQBT Eukaryota
ENOG4111BF1 LUCA
GeneTreeiENSGT00390000002205
HOGENOMiHOG000007404
HOVERGENiHBG005805
InParanoidiO43903
OMAiWETFESY
OrthoDBiEOG091G0PJ6
PhylomeDBiO43903
TreeFamiTF323754

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR029929 GAS2
PANTHERiPTHR44350:SF2 PTHR44350:SF2, 2 hits
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF02187 GAS2, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00243 GAS2, 1 hit
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51460 GAR, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43903-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK
60 70 80 90 100
EITAETFMEK LDNGALLCQL AETMQEKFKE SMDANKPTKN LPLKKIPCKT
110 120 130 140 150
SAPSGSFFAR DNTANFLSWC RDLGVDETCL FESEGLVLHK QPREVCLCLL
160 170 180 190 200
ELGRIAARYG VEPPGLIKLE KEIEQEETLS APSPSPSPSS KSSGKKSTGN
210 220 230 240 250
LLDDAVKRIS EDPPCKCPNK FCVERLSQGR YRVGEKILFI RMLHNKHVMV
260 270 280 290 300
RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPIQSKSPT LKDMNPDNYL
310
VVSASYKAKK EIK
Length:313
Mass (Da):34,945
Last modified:June 1, 1998 - v1
Checksum:iA5FBA611A0C8B36F
GO
Isoform 2 (identifier: O43903-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-141: VLHKQ → GFGGQ
     142-313: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):15,635
Checksum:i22C8443039AADADF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM28E9PM28_HUMAN
Growth arrest-specific protein 2
GAS2
155Annotation score:
E9PQ74E9PQ74_HUMAN
Growth arrest-specific protein 2
GAS2
181Annotation score:
E9PRR5E9PRR5_HUMAN
Growth arrest-specific protein 2
GAS2
205Annotation score:
E9PQ37E9PQ37_HUMAN
Growth arrest-specific protein 2
GAS2
136Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055080137 – 141VLHKQ → GFGGQ in isoform 2. 1 Publication5
Alternative sequenceiVSP_055081142 – 313Missing in isoform 2. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95032 mRNA Translation: AAC52058.1
CR450285 mRNA Translation: CAG29281.1
AK313734 mRNA Translation: BAG36475.1
AC006299 Genomic DNA No translation available.
AC103801 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68317.1
CH471064 Genomic DNA Translation: EAW68318.1
BC013326 mRNA Translation: AAH13326.1
BC040470 mRNA Translation: AAH40470.1
CCDSiCCDS7858.1 [O43903-1]
RefSeqiNP_001137302.1, NM_001143830.1 [O43903-1]
NP_005247.1, NM_005256.3 [O43903-1]
NP_808221.1, NM_177553.2 [O43903-1]
XP_016873017.1, XM_017017528.1
XP_016873018.1, XM_017017529.1
XP_016873019.1, XM_017017530.1
XP_016873020.1, XM_017017531.1
UniGeneiHs.711297

Genome annotation databases

EnsembliENST00000278187; ENSP00000278187; ENSG00000148935 [O43903-1]
ENST00000454584; ENSP00000401145; ENSG00000148935 [O43903-1]
ENST00000524701; ENSP00000432026; ENSG00000148935 [O43903-2]
ENST00000630668; ENSP00000485708; ENSG00000148935 [O43903-2]
GeneIDi2620
KEGGihsa:2620
UCSCiuc001mqm.4 human [O43903-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95032 mRNA Translation: AAC52058.1
CR450285 mRNA Translation: CAG29281.1
AK313734 mRNA Translation: BAG36475.1
AC006299 Genomic DNA No translation available.
AC103801 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68317.1
CH471064 Genomic DNA Translation: EAW68318.1
BC013326 mRNA Translation: AAH13326.1
BC040470 mRNA Translation: AAH40470.1
CCDSiCCDS7858.1 [O43903-1]
RefSeqiNP_001137302.1, NM_001143830.1 [O43903-1]
NP_005247.1, NM_005256.3 [O43903-1]
NP_808221.1, NM_177553.2 [O43903-1]
XP_016873017.1, XM_017017528.1
XP_016873018.1, XM_017017529.1
XP_016873019.1, XM_017017530.1
XP_016873020.1, XM_017017531.1
UniGeneiHs.711297

3D structure databases

ProteinModelPortaliO43903
SMRiO43903
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108890, 2 interactors
IntActiO43903, 1 interactor
STRINGi9606.ENSP00000278187

PTM databases

iPTMnetiO43903
PhosphoSitePlusiO43903

Polymorphism and mutation databases

BioMutaiGAS2

Proteomic databases

MaxQBiO43903
PaxDbiO43903
PeptideAtlasiO43903
PRIDEiO43903
ProteomicsDBi49224

Protocols and materials databases

DNASUi2620
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278187; ENSP00000278187; ENSG00000148935 [O43903-1]
ENST00000454584; ENSP00000401145; ENSG00000148935 [O43903-1]
ENST00000524701; ENSP00000432026; ENSG00000148935 [O43903-2]
ENST00000630668; ENSP00000485708; ENSG00000148935 [O43903-2]
GeneIDi2620
KEGGihsa:2620
UCSCiuc001mqm.4 human [O43903-1]

Organism-specific databases

CTDi2620
DisGeNETi2620
EuPathDBiHostDB:ENSG00000148935.10
GeneCardsiGAS2
HGNCiHGNC:4167 GAS2
HPAiHPA058904
MIMi602835 gene
neXtProtiNX_O43903
OpenTargetsiENSG00000148935
PharmGKBiPA28580
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQBT Eukaryota
ENOG4111BF1 LUCA
GeneTreeiENSGT00390000002205
HOGENOMiHOG000007404
HOVERGENiHBG005805
InParanoidiO43903
OMAiWETFESY
OrthoDBiEOG091G0PJ6
PhylomeDBiO43903
TreeFamiTF323754

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
SIGNORiO43903

Miscellaneous databases

ChiTaRSiGAS2 human
GeneWikiiGAS2
GenomeRNAii2620
PMAP-CutDBiO43903
PROiPR:O43903
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148935 Expressed in 174 organ(s), highest expression level in liver
CleanExiHS_GAS2
ExpressionAtlasiO43903 baseline and differential
GenevisibleiO43903 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR029929 GAS2
PANTHERiPTHR44350:SF2 PTHR44350:SF2, 2 hits
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF02187 GAS2, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00243 GAS2, 1 hit
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51460 GAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAS2_HUMAN
AccessioniPrimary (citable) accession number: O43903
Secondary accession number(s): B2R9C8
, D3DQZ0, Q6ICV8, Q7Z3X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again