UniProtKB - O43896 (KIF1C_HUMAN)
Protein
Kinesin-like protein KIF1C
Gene
KIF1C
Organism
Homo sapiens (Human)
Status
Functioni
Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 97 – 104 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
- microtubule binding Source: GO_Central
- microtubule motor activity Source: GO_Central
- motor activity Source: ProtInc
- RNA binding Source: UniProtKB
GO - Biological processi
- anterograde neuronal dense core vesicle transport Source: ARUK-UCL
- cytoskeleton-dependent intracellular transport Source: GO_Central
- microtubule-based movement Source: GO_Central
- retrograde neuronal dense core vesicle transport Source: ARUK-UCL
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: ProtInc
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O43896 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
SIGNORi | O43896 |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF1C |
Gene namesi | Name:KIF1C Synonyms:KIAA0706 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6317, KIF1C |
MIMi | 603060, gene |
neXtProti | NX_O43896 |
VEuPathDBi | HostDB:ENSG00000129250.11 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum Source: ProtInc
Golgi apparatus
- Golgi apparatus Source: ProtInc
Other locations
- axon Source: GO_Central
- axon cytoplasm Source: GOC
- dendrite Source: GO_Central
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Involvement in diseasei
Spastic ataxia 2, autosomal recessive (SPAX2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070937 | 169 | R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, NeurodegenerationOrganism-specific databases
DisGeNETi | 10749 |
MalaCardsi | KIF1C |
MIMi | 611302, phenotype |
OpenTargetsi | ENSG00000129250 |
Orphaneti | 397946, Autosomal spastic paraplegia type 58 |
PharmGKBi | PA30100 |
Miscellaneous databases
Pharosi | O43896, Tbio |
Genetic variation databases
BioMutai | KIF1C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125410 | 1 – 1103 | Kinesin-like protein KIF1CAdd BLAST | 1103 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 494 | PhosphoserineCombined sources | 1 | |
Modified residuei | 674 | PhosphoserineCombined sources | 1 | |
Modified residuei | 676 | PhosphoserineCombined sources | 1 | |
Modified residuei | 915 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1033 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1041 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 1083 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1092 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues.1 Publication
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | O43896 |
jPOSTi | O43896 |
MassIVEi | O43896 |
MaxQBi | O43896 |
PaxDbi | O43896 |
PeptideAtlasi | O43896 |
PRIDEi | O43896 |
ProteomicsDBi | 49220 |
PTM databases
iPTMneti | O43896 |
MetOSitei | O43896 |
PhosphoSitePlusi | O43896 |
Expressioni
Tissue specificityi
Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000129250, Expressed in gastrocnemius and 252 other tissues |
ExpressionAtlasi | O43896, baseline and differential |
Genevisiblei | O43896, HS |
Organism-specific databases
HPAi | ENSG00000129250, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Monomer.
Interacts with BICD2.
Curated1 PublicationBinary interactionsi
O43896
With | #Exp. | IntAct |
---|---|---|
Bicdl1 [A0JNT9] from Mus musculus. | 3 | EBI-1644048,EBI-7893170 |
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 115972, 89 interactors |
DIPi | DIP-40376N |
IntActi | O43896, 39 interactors |
MINTi | O43896 |
STRINGi | 9606.ENSP00000320821 |
Miscellaneous databases
RNActi | O43896, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O43896 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43896 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 348 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 344 | |
Domaini | 523 – 590 | FHAAdd BLAST | 68 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 359 – 388 | Sequence analysisAdd BLAST | 30 | |
Coiled coili | 438 – 479 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 633 – 674 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 828 – 872 | Sequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 965 – 1085 | Pro-richAdd BLAST | 121 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000159295 |
HOGENOMi | CLU_009645_0_0_1 |
InParanoidi | O43896 |
OMAi | WAQPQGS |
OrthoDBi | 76316at2759 |
PhylomeDBi | O43896 |
TreeFami | TF105221 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR027640, Kinesin-like_fam IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O43896-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF
60 70 80 90 100
TFDYSYWSHT STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV SENQSAQLSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK VSKISLVDLA
260 270 280 290 300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY
310 320 330 340 350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC
360 370 380 390 400
NAIINEDPNA RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA
410 420 430 440 450
LPAVSSPPAP VSPSSPTTHN GELEPSFSPN TESQIGPEEA MERLQETEKI
460 470 480 490 500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH
510 520 530 540 550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR EQHCLFRSIP
560 570 580 590 600
QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP
610 620 630 640 650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL
660 670 680 690 700
ENQYRKEKEE ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP
710 720 730 740 750
PTTVQTIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ
760 770 780 790 800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPD GPGDAWRAVA
810 820 830 840 850
RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL TGILQEVKLQ
860 870 880 890 900
NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE
910 920 930 940 950
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ
960 970 980 990 1000
GLQGSGGRGG GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP
1010 1020 1030 1040 1050
TPLQPPEEVT PHPATPARRP PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP
1060 1070 1080 1090 1100
QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP YTTPPRMRRQ RSAPDLKESG
AAV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L1B1 | I3L1B1_HUMAN | Kinesin-like protein KIF1C | KIF1C | 138 | Annotation score: |
Sequence cautioni
The sequence BAA31681 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 669 | R → Q in AAC52117 (PubMed:9685376).Curated | 1 | |
Sequence conflicti | 955 – 962 | SGGRGGGL → LWGPGRGV in AAC52117 (PubMed:9685376).Curated | 8 | |
Sequence conflicti | 976 – 977 | KL → NV in AAC52117 (PubMed:9685376).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070937 | 169 | R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91329 mRNA Translation: AAC52117.1 AB014606 mRNA Translation: BAA31681.2 Different initiation. CH471108 Genomic DNA Translation: EAW90366.1 CH471108 Genomic DNA Translation: EAW90367.1 CH471108 Genomic DNA Translation: EAW90368.1 CH471108 Genomic DNA Translation: EAW90369.1 BC034993 mRNA Translation: AAH34993.1 |
CCDSi | CCDS11065.1 |
RefSeqi | NP_006603.2, NM_006612.5 XP_005256481.1, XM_005256424.2 |
Genome annotation databases
Ensembli | ENST00000320785; ENSP00000320821; ENSG00000129250 |
GeneIDi | 10749 |
KEGGi | hsa:10749 |
UCSCi | uc002gan.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91329 mRNA Translation: AAC52117.1 AB014606 mRNA Translation: BAA31681.2 Different initiation. CH471108 Genomic DNA Translation: EAW90366.1 CH471108 Genomic DNA Translation: EAW90367.1 CH471108 Genomic DNA Translation: EAW90368.1 CH471108 Genomic DNA Translation: EAW90369.1 BC034993 mRNA Translation: AAH34993.1 |
CCDSi | CCDS11065.1 |
RefSeqi | NP_006603.2, NM_006612.5 XP_005256481.1, XM_005256424.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G1L | X-ray | 2.60 | A | 498-599 | [»] | |
SMRi | O43896 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115972, 89 interactors |
DIPi | DIP-40376N |
IntActi | O43896, 39 interactors |
MINTi | O43896 |
STRINGi | 9606.ENSP00000320821 |
PTM databases
iPTMneti | O43896 |
MetOSitei | O43896 |
PhosphoSitePlusi | O43896 |
Genetic variation databases
BioMutai | KIF1C |
Proteomic databases
EPDi | O43896 |
jPOSTi | O43896 |
MassIVEi | O43896 |
MaxQBi | O43896 |
PaxDbi | O43896 |
PeptideAtlasi | O43896 |
PRIDEi | O43896 |
ProteomicsDBi | 49220 |
Protocols and materials databases
Antibodypediai | 11469, 132 antibodies |
Genome annotation databases
Ensembli | ENST00000320785; ENSP00000320821; ENSG00000129250 |
GeneIDi | 10749 |
KEGGi | hsa:10749 |
UCSCi | uc002gan.3, human |
Organism-specific databases
CTDi | 10749 |
DisGeNETi | 10749 |
GeneCardsi | KIF1C |
HGNCi | HGNC:6317, KIF1C |
HPAi | ENSG00000129250, Tissue enhanced (skeletal) |
MalaCardsi | KIF1C |
MIMi | 603060, gene 611302, phenotype |
neXtProti | NX_O43896 |
OpenTargetsi | ENSG00000129250 |
Orphaneti | 397946, Autosomal spastic paraplegia type 58 |
PharmGKBi | PA30100 |
VEuPathDBi | HostDB:ENSG00000129250.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000159295 |
HOGENOMi | CLU_009645_0_0_1 |
InParanoidi | O43896 |
OMAi | WAQPQGS |
OrthoDBi | 76316at2759 |
PhylomeDBi | O43896 |
TreeFami | TF105221 |
Enzyme and pathway databases
PathwayCommonsi | O43896 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
SIGNORi | O43896 |
Miscellaneous databases
BioGRID-ORCSi | 10749, 6 hits in 875 CRISPR screens |
ChiTaRSi | KIF1C, human |
EvolutionaryTracei | O43896 |
GeneWikii | KIF1C |
GenomeRNAii | 10749 |
Pharosi | O43896, Tbio |
PROi | PR:O43896 |
RNActi | O43896, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129250, Expressed in gastrocnemius and 252 other tissues |
ExpressionAtlasi | O43896, baseline and differential |
Genevisiblei | O43896, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR027640, Kinesin-like_fam IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF1C_HUMAN | |
Accessioni | O43896Primary (citable) accession number: O43896 Secondary accession number(s): D3DTL6, O75186, Q5U618 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants