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UniProtKB - O43896 (KIF1C_HUMAN)

Entry version 188 (10 Feb 2021)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Kinesin-like protein KIF1C

Gene

KIF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43896

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43896

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF1C
Synonyms:KIAA0706
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6317, KIF1C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603060, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43896

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000129250.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic ataxia 2, autosomal recessive (SPAX2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070937169R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		10749

MalaCards human disease database

More...MalaCardsi		KIF1C
MIMi611302, phenotype

Open Targets

More...OpenTargetsi		ENSG00000129250

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		397946, Autosomal spastic paraplegia type 58

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30100

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43896, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIF1C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254101 – 1103Kinesin-like protein KIF1CAdd BLAST1103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1041Omega-N-methylarginineCombined sources1
Modified residuei1083PhosphothreonineCombined sources1
Modified residuei1092PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43896

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43896

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43896

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43896

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43896

PeptideAtlas

More...PeptideAtlasi		O43896

PRoteomics IDEntifications database

More...PRIDEi		O43896

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49220

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43896

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O43896

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43896

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129250, Expressed in gastrocnemius and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43896, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43896, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129250, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with BICD2.

Curated1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115972, 89 interactors

Database of interacting proteins

More...DIPi		DIP-40376N

Protein interaction database and analysis system

More...IntActi		O43896, 39 interactors

Molecular INTeraction database

More...MINTi		O43896

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000320821

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43896, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43896

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43896

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 348Kinesin motorPROSITE-ProRule annotationAdd BLAST344
Domaini523 – 590FHAAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili359 – 388Sequence analysisAdd BLAST30
Coiled coili438 – 479Sequence analysisAdd BLAST42
Coiled coili633 – 674Sequence analysisAdd BLAST42
Coiled coili828 – 872Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi965 – 1085Pro-richAdd BLAST121

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0245, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159295

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009645_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43896

Identification of Orthologs from Complete Genome Data

More...OMAi		WAQPQGS

Database of Orthologous Groups

More...OrthoDBi		76316at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43896

TreeFam database of animal gene trees

More...TreeFami		TF105221

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253, FHA_dom
IPR027640, Kinesin-like_fam
IPR032405, Kinesin_assoc
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
IPR008984, SMAD_FHA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24115, PTHR24115, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00498, FHA, 1 hit
PF00225, Kinesin, 1 hit
PF16183, Kinesin_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF 
        60         70         80         90        100
TFDYSYWSHT STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG 
       110        120        130        140        150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV SENQSAQLSY SVEVSYMEIY 
       160        170        180        190        200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN 
       210        220        230        240        250
KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK VSKISLVDLA 
       260        270        280        290        300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY 
       310        320        330        340        350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC 
       360        370        380        390        400
NAIINEDPNA RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA 
       410        420        430        440        450
LPAVSSPPAP VSPSSPTTHN GELEPSFSPN TESQIGPEEA MERLQETEKI 
       460        470        480        490        500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH 
       510        520        530        540        550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR EQHCLFRSIP 
       560        570        580        590        600
QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP 
       610        620        630        640        650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL 
       660        670        680        690        700
ENQYRKEKEE ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP 
       710        720        730        740        750
PTTVQTIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ 
       760        770        780        790        800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPD GPGDAWRAVA 
       810        820        830        840        850
RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL TGILQEVKLQ 
       860        870        880        890        900
NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE 
       910        920        930        940        950
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ 
       960        970        980        990       1000
GLQGSGGRGG GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP 
      1010       1020       1030       1040       1050
TPLQPPEEVT PHPATPARRP PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP 
      1060       1070       1080       1090       1100
QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP YTTPPRMRRQ RSAPDLKESG 

AAV
Length:1,103
Mass (Da):122,947
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FDEEB8C91B3C46B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1B1I3L1B1_HUMAN
Kinesin-like protein KIF1C
KIF1C
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31681 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti669R → Q in AAC52117 (PubMed:9685376).Curated1
Sequence conflicti955 – 962SGGRGGGL → LWGPGRGV in AAC52117 (PubMed:9685376).Curated8
Sequence conflicti976 – 977KL → NV in AAC52117 (PubMed:9685376).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070937169R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U91329 mRNA Translation: AAC52117.1
AB014606 mRNA Translation: BAA31681.2 Different initiation.
CH471108 Genomic DNA Translation: EAW90366.1
CH471108 Genomic DNA Translation: EAW90367.1
CH471108 Genomic DNA Translation: EAW90368.1
CH471108 Genomic DNA Translation: EAW90369.1
BC034993 mRNA Translation: AAH34993.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11065.1

NCBI Reference Sequences

More...RefSeqi		NP_006603.2, NM_006612.5
XP_005256481.1, XM_005256424.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000320785; ENSP00000320821; ENSG00000129250

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10749

UCSC genome browser

More...UCSCi		uc002gan.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91329 mRNA Translation: AAC52117.1
AB014606 mRNA Translation: BAA31681.2 Different initiation.
CH471108 Genomic DNA Translation: EAW90366.1
CH471108 Genomic DNA Translation: EAW90367.1
CH471108 Genomic DNA Translation: EAW90368.1
CH471108 Genomic DNA Translation: EAW90369.1
BC034993 mRNA Translation: AAH34993.1
CCDSiCCDS11065.1
RefSeqiNP_006603.2, NM_006612.5
XP_005256481.1, XM_005256424.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G1LX-ray2.60A498-599[»]
SMRiO43896
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115972, 89 interactors
DIPiDIP-40376N
IntActiO43896, 39 interactors
MINTiO43896
STRINGi9606.ENSP00000320821

PTM databases

iPTMnetiO43896
MetOSiteiO43896
PhosphoSitePlusiO43896

Genetic variation databases

BioMutaiKIF1C

Proteomic databases

EPDiO43896
jPOSTiO43896
MassIVEiO43896
MaxQBiO43896
PaxDbiO43896
PeptideAtlasiO43896
PRIDEiO43896
ProteomicsDBi49220

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11469, 132 antibodies

Genome annotation databases

EnsembliENST00000320785; ENSP00000320821; ENSG00000129250
GeneIDi10749
KEGGihsa:10749
UCSCiuc002gan.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10749
DisGeNETi10749

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIF1C
HGNCiHGNC:6317, KIF1C
HPAiENSG00000129250, Tissue enhanced (skeletal)
MalaCardsiKIF1C
MIMi603060, gene
611302, phenotype
neXtProtiNX_O43896
OpenTargetsiENSG00000129250
Orphaneti397946, Autosomal spastic paraplegia type 58
PharmGKBiPA30100
VEuPathDBiHostDB:ENSG00000129250.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0245, Eukaryota
GeneTreeiENSGT00940000159295
HOGENOMiCLU_009645_0_0_1
InParanoidiO43896
OMAiWAQPQGS
OrthoDBi76316at2759
PhylomeDBiO43896
TreeFamiTF105221

Enzyme and pathway databases

PathwayCommonsiO43896
ReactomeiR-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins
SIGNORiO43896

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10749, 6 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIF1C, human
EvolutionaryTraceiO43896

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KIF1C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10749
PharosiO43896, Tbio

Protein Ontology

More...PROi		PR:O43896
RNActiO43896, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000129250, Expressed in gastrocnemius and 252 other tissues
ExpressionAtlasiO43896, baseline and differential
GenevisibleiO43896, HS

Family and domain databases

CDDicd00060, FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253, FHA_dom
IPR027640, Kinesin-like_fam
IPR032405, Kinesin_assoc
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
IPR008984, SMAD_FHA_dom_sf
PANTHERiPTHR24115, PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498, FHA, 1 hit
PF00225, Kinesin, 1 hit
PF16183, Kinesin_assoc, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF1C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43896
Secondary accession number(s): D3DTL6, O75186, Q5U618
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 17, 2006
Last modified: February 10, 2021
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
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