UniProtKB - O43896 (KIF1C_HUMAN)

BLAST

>sp|O43896|KIF1C_HUMAN Kinesin-like protein KIF1C OS=Homo sapiens OX=9606 GN=KIF1C PE=1 SV=3
MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHT
STEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVP
QLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQD
LSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEK
VSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPY
RDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNA
RLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHN
GELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMG
VAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDMDIKLTGQFIR
EQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP
EQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEE
ADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRR
APRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMR
ELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKL
TGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAE
EAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGG
GLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRP
PSPRRSHHPRRNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPP
YTTPPRMRRQRSAPDLKESGAAV

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History
Entry version 174 (07 Nov 2018)
Sequence version 3 (17 Oct 2006)
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Protein

Kinesin-like protein KIF1C

Gene

KIF1C

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	97 – 104	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP binding Source: UniProtKB-KW
ATP-dependent microtubule motor activity, plus-end-directed
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule motor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
motor activity
Source: ProtInc
Traceable author statementⁱ
- 9685376
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterograde neuronal dense core vesicle transport Source: ARUK-UCL
cytoskeleton-dependent intracellular transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule-based movement
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde neuronal dense core vesicle transport Source: ARUK-UCL
retrograde vesicle-mediated transport, Golgi to ER
Source: ProtInc
Traceable author statementⁱ
- 9685376
vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189 Kinesins
SIGNORⁱ	O43896

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinesin-like protein KIF1C
Gene namesⁱ	Name:KIF1C Synonyms:KIAA0706
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129250.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6317 KIF1C
MIMⁱ	603060 gene
neXtProtⁱ	NX_O43896

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spastic ataxia 2, autosomal recessive (SPAX2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10749
MalaCards human disease database More...MalaCardsⁱ	KIF1C
MIMⁱ	611302 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000129250
Orphanetⁱ	397946 Autosomal recessive spastic paraplegia type 58
PharmGKBⁱ	PA30100

Polymorphism and mutation databases

BioMutaⁱ	KIF1C

BioMutaⁱ

KIF1C

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000125410	1 – 1103	Kinesin-like protein KIF1CAdd BLAST		1103

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	295	PhosphoserineCombined sources	1
Modified residueⁱ	494	PhosphoserineCombined sources	1
Modified residueⁱ	674	PhosphoserineCombined sources	1
Modified residueⁱ	676	PhosphoserineCombined sources	1
Modified residueⁱ	915	PhosphoserineCombined sources	1
Modified residueⁱ	1033	PhosphoserineCombined sources	1
Modified residueⁱ	1041	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1083	PhosphothreonineCombined sources	1
Modified residueⁱ	1092	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	O43896
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43896
PaxDbⁱ	O43896
PeptideAtlas More...PeptideAtlasⁱ	O43896
PRIDEⁱ	O43896
ProteomicsDBⁱ	49220

PTM databases

iPTMnetⁱ	O43896
PhosphoSitePlusⁱ	O43896

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000129250 Expressed in 239 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_KIF1C
ExpressionAtlasⁱ	O43896 baseline and differential
Genevisibleⁱ	O43896 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024602 HPA045020

HPAⁱ

HPA024602
HPA045020

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with BICD2.Curated1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Bicdl1	A0JNT9	3	EBI-1644048,EBI-7893170	From Mus musculus.

With

Entry

#Exp.

IntAct

Notes

Bicdl1

A0JNT9

EBI-1644048,EBI-7893170

From Mus musculus.

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115972, 79 interactors
Database of interacting proteins More...DIPⁱ	DIP-40376N
IntActⁱ	O43896, 33 interactors
Molecular INTeraction database More...MINTⁱ	O43896
STRINGⁱ	9606.ENSP00000320821

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	500 – 503	Combined sources	4
Beta strandⁱ	510 – 512	Combined sources	3
Beta strandⁱ	515 – 517	Combined sources	3
Beta strandⁱ	520 – 529	Combined sources	10
Beta strandⁱ	531 – 533	Combined sources	3
Beta strandⁱ	541 – 550	Combined sources	10
Beta strandⁱ	556 – 562	Combined sources	7
Beta strandⁱ	568 – 570	Combined sources	3
Beta strandⁱ	586 – 589	Combined sources	4
Turnⁱ	590 – 592	Combined sources	3
Beta strandⁱ	593 – 598	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	O43896
SMRⁱ	O43896
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O43896

EvolutionaryTraceⁱ

O43896

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 348	Kinesin motorPROSITE-ProRule annotationAdd BLAST		344
Domainⁱ	523 – 590	FHAAdd BLAST		68

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	359 – 388	Sequence analysisAdd BLAST	30
Coiled coilⁱ	438 – 479	Sequence analysisAdd BLAST	42
Coiled coilⁱ	633 – 674	Sequence analysisAdd BLAST	42
Coiled coilⁱ	828 – 872	Sequence analysisAdd BLAST	45

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	965 – 1085	Pro-richAdd BLAST		121

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0245 Eukaryota COG5059 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150817
HOGENOMⁱ	HOG000231453
HOVERGENⁱ	HBG057158
InParanoidⁱ	O43896
KEGG Orthology (KO) More...KOⁱ	K10392
OMAⁱ	PKGTPHL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G009V
PhylomeDBⁱ	O43896
TreeFamⁱ	TF105221

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00060 FHA, 1 hit
Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR027640 Kinesin-like_fam IPR032405 Kinesin_assoc IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase IPR008984 SMAD_FHA_dom_sf
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit PF00225 Kinesin, 1 hit PF16183 Kinesin_assoc, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00129 KISc, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O43896-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF 
        60         70         80         90        100
TFDYSYWSHT STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG 
       110        120        130        140        150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV SENQSAQLSY SVEVSYMEIY 
       160        170        180        190        200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN 
       210        220        230        240        250
KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK VSKISLVDLA 
       260        270        280        290        300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY 
       310        320        330        340        350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC 
       360        370        380        390        400
NAIINEDPNA RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA 
       410        420        430        440        450
LPAVSSPPAP VSPSSPTTHN GELEPSFSPN TESQIGPEEA MERLQETEKI 
       460        470        480        490        500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH 
       510        520        530        540        550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR EQHCLFRSIP 
       560        570        580        590        600
QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP 
       610        620        630        640        650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL 
       660        670        680        690        700
ENQYRKEKEE ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP 
       710        720        730        740        750
PTTVQTIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ 
       760        770        780        790        800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPD GPGDAWRAVA 
       810        820        830        840        850
RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL TGILQEVKLQ 
       860        870        880        890        900
NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE 
       910        920        930        940        950
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ 
       960        970        980        990       1000
GLQGSGGRGG GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP 
      1010       1020       1030       1040       1050
TPLQPPEEVT PHPATPARRP PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP 
      1060       1070       1080       1090       1100
QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP YTTPPRMRRQ RSAPDLKESG 

AAV

Length:1,103

Mass (Da):122,947

Last modified:October 17, 2006 - v3

Checksum:ⁱ5FDEEB8C91B3C46B

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	I3L1B1	I3L1B1_HUMAN		Kinesin-like protein KIF1C Kinesin-like protein KIF1C	KIF1C	138	Annotation score:

Sequence cautionⁱ

The sequence BAA31681 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	669	R → Q in AAC52117 (PubMed:9685376).Curated	1
Sequence conflictⁱ	955 – 962	SGGRGGGL → LWGPGRGV in AAC52117 (PubMed:9685376).Curated	8
Sequence conflictⁱ	976 – 977	KL → NV in AAC52117 (PubMed:9685376).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070937	169	R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91329 mRNA Translation: AAC52117.1 AB014606 mRNA Translation: BAA31681.2 Different initiation. CH471108 Genomic DNA Translation: EAW90366.1 CH471108 Genomic DNA Translation: EAW90367.1 CH471108 Genomic DNA Translation: EAW90368.1 CH471108 Genomic DNA Translation: EAW90369.1 BC034993 mRNA Translation: AAH34993.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11065.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006603.2, NM_006612.5 XP_005256481.1, XM_005256424.2
UniGeneⁱ	Hs.435120

Genome annotation databases

Ensemblⁱ	ENST00000320785; ENSP00000320821; ENSG00000129250
GeneIDⁱ	10749
KEGGⁱ	hsa:10749
UCSC genome browser More...UCSCⁱ	uc002gan.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43896	Kinesin-like protein KIF1C (Fragment)		HUMAN		138	UniRef100_O43896

Protein	Similar proteins		Species	Score	Length	Source
O43896	Kinesin-like protein KIF1C		MOUSE		1100	UniRef90_O43896
Kinesin-like protein KIF1C		RAT		1097
Kinesin-like protein KIF1C (Fragment)		HUMAN		138
Kinesin-like protein KIF1C		MYODS		1157
kinesin-like protein KIF1C isoform X1		ODORO		1141
+138

Protein	Similar proteins		Species	Score	Length	Source
O43896	Kinesin-like protein KIF1C		MOUSE		1100	UniRef50_O43896
Kinesin-like protein KIF1C		RAT		1097
Kinesin-like protein KIF1C (Fragment)		HUMAN		138
Kinesin-like protein KIF1C		MYODS		1157
kinesin-like protein KIF1C isoform X1		ODORO		1141
+151

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91329 mRNA Translation: AAC52117.1 AB014606 mRNA Translation: BAA31681.2 Different initiation. CH471108 Genomic DNA Translation: EAW90366.1 CH471108 Genomic DNA Translation: EAW90367.1 CH471108 Genomic DNA Translation: EAW90368.1 CH471108 Genomic DNA Translation: EAW90369.1 BC034993 mRNA Translation: AAH34993.1
CCDSⁱ	CCDS11065.1
RefSeqⁱ	NP_006603.2, NM_006612.5 XP_005256481.1, XM_005256424.2
UniGeneⁱ	Hs.435120

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2G1L	X-ray	2.60	A	498-599	[»]
ProteinModelPortalⁱ	O43896
SMRⁱ	O43896
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115972, 79 interactors
DIPⁱ	DIP-40376N
IntActⁱ	O43896, 33 interactors
MINTⁱ	O43896
STRINGⁱ	9606.ENSP00000320821

PTM databases

iPTMnetⁱ	O43896
PhosphoSitePlusⁱ	O43896

Polymorphism and mutation databases

BioMutaⁱ	KIF1C

BioMutaⁱ

KIF1C

Proteomic databases

EPDⁱ	O43896
MaxQBⁱ	O43896
PaxDbⁱ	O43896
PeptideAtlasⁱ	O43896
PRIDEⁱ	O43896
ProteomicsDBⁱ	49220

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000320785; ENSP00000320821; ENSG00000129250
GeneIDⁱ	10749
KEGGⁱ	hsa:10749
UCSCⁱ	uc002gan.3 human

Organism-specific databases

CTDⁱ	10749
DisGeNETⁱ	10749
EuPathDBⁱ	HostDB:ENSG00000129250.11
GeneCardsⁱ	KIF1C
HGNCⁱ	HGNC:6317 KIF1C
HPAⁱ	HPA024602 HPA045020
MalaCardsⁱ	KIF1C
MIMⁱ	603060 gene 611302 phenotype
neXtProtⁱ	NX_O43896
OpenTargetsⁱ	ENSG00000129250
Orphanetⁱ	397946 Autosomal recessive spastic paraplegia type 58
PharmGKBⁱ	PA30100
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0245 Eukaryota COG5059 LUCA
GeneTreeⁱ	ENSGT00930000150817
HOGENOMⁱ	HOG000231453
HOVERGENⁱ	HBG057158
InParanoidⁱ	O43896
KOⁱ	K10392
OMAⁱ	PKGTPHL
OrthoDBⁱ	EOG091G009V
PhylomeDBⁱ	O43896
TreeFamⁱ	TF105221

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189 Kinesins
SIGNORⁱ	O43896

Miscellaneous databases

ChiTaRSⁱ	KIF1C human
EvolutionaryTraceⁱ	O43896
GeneWikiⁱ	KIF1C
GenomeRNAiⁱ	10749
Protein Ontology More...PROⁱ	PR:O43896
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129250 Expressed in 239 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_KIF1C
ExpressionAtlasⁱ	O43896 baseline and differential
Genevisibleⁱ	O43896 HS

Family and domain databases

CDDⁱ	cd00060 FHA, 1 hit
Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR027640 Kinesin-like_fam IPR032405 Kinesin_assoc IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase IPR008984 SMAD_FHA_dom_sf
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit
Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit PF00225 Kinesin, 1 hit PF16183 Kinesin_assoc, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00129 KISc, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KIF1C_HUMAN
Accessionⁱ	O43896Primary (citable) accession number: O43896 Secondary accession number(s): D3DTL6, O75186, Q5U618
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43896 (KIF1C_HUMAN)

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Kinesin-like protein KIF1C

KIF1C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Endoplasmic reticulum

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ