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Protein

Kinesin-like protein KIF1C

Gene

KIF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central
  • motor activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins
SIGNORiO43896

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1C
Gene namesi
Name:KIF1C
Synonyms:KIAA0706
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129250.11
HGNCiHGNC:6317 KIF1C
MIMi603060 gene
neXtProtiNX_O43896

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Spastic ataxia 2, autosomal recessive (SPAX2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
See also OMIM:611302
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070937169R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi10749
MalaCardsiKIF1C
MIMi611302 phenotype
OpenTargetsiENSG00000129250
Orphaneti397946 Autosomal recessive spastic paraplegia type 58
PharmGKBiPA30100

Polymorphism and mutation databases

BioMutaiKIF1C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254101 – 1103Kinesin-like protein KIF1CAdd BLAST1103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1041Omega-N-methylarginineCombined sources1
Modified residuei1083PhosphothreonineCombined sources1
Modified residuei1092PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO43896
MaxQBiO43896
PaxDbiO43896
PeptideAtlasiO43896
PRIDEiO43896
ProteomicsDBi49220

PTM databases

iPTMnetiO43896
PhosphoSitePlusiO43896

Expressioni

Tissue specificityi

Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000129250
CleanExiHS_KIF1C
ExpressionAtlasiO43896 baseline and differential
GenevisibleiO43896 HS

Organism-specific databases

HPAiHPA024602
HPA045020

Interactioni

Subunit structurei

Monomer. Interacts with BICD2.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Bicdl1A0JNT93EBI-1644048,EBI-7893170From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115972, 79 interactors
DIPiDIP-40376N
IntActiO43896, 75 interactors
MINTiO43896
STRINGi9606.ENSP00000320821

Structurei

Secondary structure

11103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi500 – 503Combined sources4
Beta strandi510 – 512Combined sources3
Beta strandi515 – 517Combined sources3
Beta strandi520 – 529Combined sources10
Beta strandi531 – 533Combined sources3
Beta strandi541 – 550Combined sources10
Beta strandi556 – 562Combined sources7
Beta strandi568 – 570Combined sources3
Beta strandi586 – 589Combined sources4
Turni590 – 592Combined sources3
Beta strandi593 – 598Combined sources6

3D structure databases

ProteinModelPortaliO43896
SMRiO43896
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43896

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 348Kinesin motorPROSITE-ProRule annotationAdd BLAST344
Domaini523 – 590FHAAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili359 – 388Sequence analysisAdd BLAST30
Coiled coili438 – 479Sequence analysisAdd BLAST42
Coiled coili633 – 674Sequence analysisAdd BLAST42
Coiled coili828 – 872Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi965 – 1085Pro-richAdd BLAST121

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00890000139327
HOGENOMiHOG000231453
HOVERGENiHBG057158
InParanoidiO43896
KOiK10392
OMAiTSQDAKC
OrthoDBiEOG091G009V
PhylomeDBiO43896
TreeFamiTF105221

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O43896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF
60 70 80 90 100
TFDYSYWSHT STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV SENQSAQLSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK VSKISLVDLA
260 270 280 290 300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY
310 320 330 340 350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC
360 370 380 390 400
NAIINEDPNA RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA
410 420 430 440 450
LPAVSSPPAP VSPSSPTTHN GELEPSFSPN TESQIGPEEA MERLQETEKI
460 470 480 490 500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH
510 520 530 540 550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR EQHCLFRSIP
560 570 580 590 600
QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP
610 620 630 640 650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL
660 670 680 690 700
ENQYRKEKEE ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP
710 720 730 740 750
PTTVQTIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ
760 770 780 790 800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPD GPGDAWRAVA
810 820 830 840 850
RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL TGILQEVKLQ
860 870 880 890 900
NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE
910 920 930 940 950
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ
960 970 980 990 1000
GLQGSGGRGG GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP
1010 1020 1030 1040 1050
TPLQPPEEVT PHPATPARRP PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP
1060 1070 1080 1090 1100
QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP YTTPPRMRRQ RSAPDLKESG

AAV
Length:1,103
Mass (Da):122,947
Last modified:October 17, 2006 - v3
Checksum:i5FDEEB8C91B3C46B
GO

Sequence cautioni

The sequence BAA31681 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti669R → Q in AAC52117 (PubMed:9685376).Curated1
Sequence conflicti955 – 962SGGRGGGL → LWGPGRGV in AAC52117 (PubMed:9685376).Curated8
Sequence conflicti976 – 977KL → NV in AAC52117 (PubMed:9685376).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070937169R → W in SPAX2. 1 PublicationCorresponds to variant dbSNP:rs587777198EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91329 mRNA Translation: AAC52117.1
AB014606 mRNA Translation: BAA31681.2 Different initiation.
CH471108 Genomic DNA Translation: EAW90366.1
CH471108 Genomic DNA Translation: EAW90367.1
CH471108 Genomic DNA Translation: EAW90368.1
CH471108 Genomic DNA Translation: EAW90369.1
BC034993 mRNA Translation: AAH34993.1
CCDSiCCDS11065.1
RefSeqiNP_006603.2, NM_006612.5
XP_005256481.1, XM_005256424.2
UniGeneiHs.435120

Genome annotation databases

EnsembliENST00000320785; ENSP00000320821; ENSG00000129250
GeneIDi10749
KEGGihsa:10749
UCSCiuc002gan.3 human

Similar proteinsi

Entry informationi

Entry nameiKIF1C_HUMAN
AccessioniPrimary (citable) accession number: O43896
Secondary accession number(s): D3DTL6, O75186, Q5U618
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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