Cyclic AMP-responsive element-binding protein 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cAMP response element binding Source: InterPro
• cAMP response element binding protein binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."
    Lu R., Yang P., O'Hare P., Misra V.
    Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), DNA-BINDING (ISOFORM 1), INTERACTION WITH HCFC1 (ISOFORM 1), TISSUE SPECIFICITY.
• CCR1 chemokine receptor binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.13

    "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
    Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
    FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING, INTERACTION WITH CCR1.
• chromatin binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• DNA binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation."
    Jin D.-Y., Wang H.-L., Zhou Y., Chun A.C.S., Kibler K.V., Hou Y.-D., Kung H.-F., Jeang K.-T.
    EMBO J. 19:729-740(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION IN CELL PROLIFERATION (MICROBIAL INFECTION), HOMODIMERIZATION, INTERACTION WITH HCV CORE PROTEIN (MICROBIAL INFECTION), DNA-BINDING, SUBCELLULAR LOCATION.
  • Ref.1

    "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."
    Lu R., Yang P., O'Hare P., Misra V.
    Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), DNA-BINDING (ISOFORM 1), INTERACTION WITH HCFC1 (ISOFORM 1), TISSUE SPECIFICITY.
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• DNA-binding transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation."
    Jin D.-Y., Wang H.-L., Zhou Y., Chun A.C.S., Kibler K.V., Hou Y.-D., Kung H.-F., Jeang K.-T.
    EMBO J. 19:729-740(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION IN CELL PROLIFERATION (MICROBIAL INFECTION), HOMODIMERIZATION, INTERACTION WITH HCV CORE PROTEIN (MICROBIAL INFECTION), DNA-BINDING, SUBCELLULAR LOCATION.
  • "Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model."
    Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B.
    Apoptosis 15:631-638(2010) [PubMed] [Europe PMC] [Abstract]
  • "Sustained rolling of microparticles in shear flow over an electrostatically patchy surface."
    Kalasin S., Santore M.M.
    Langmuir 26:2317-2324(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• protein dimerization activity Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.9

    "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency."
    Lu R., Misra V.
    J. Virol. 74:934-943(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN HSV-1 INFECTION (MICROBIAL INFECTION), MUTAGENESIS OF TYR-81, SUBCELLULAR LOCATION (ISOFORM 1).
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation."
    Jin D.-Y., Wang H.-L., Zhou Y., Chun A.C.S., Kibler K.V., Hou Y.-D., Kung H.-F., Jeang K.-T.
    EMBO J. 19:729-740(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION IN CELL PROLIFERATION (MICROBIAL INFECTION), HOMODIMERIZATION, INTERACTION WITH HCV CORE PROTEIN (MICROBIAL INFECTION), DNA-BINDING, SUBCELLULAR LOCATION.
  • "Sustained rolling of microparticles in shear flow over an electrostatically patchy surface."
    Kalasin S., Santore M.M.
    Langmuir 26:2317-2324(2010) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• sequence-specific double-stranded DNA binding Source: ARUK-UCLInferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• chemotaxis Source: UniProtKB-KW
• cytoplasmic sequestering of transcription factor Source: UniProtKBInferred from direct assayⁱ
  • "Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model."
    Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B.
    Apoptosis 15:631-638(2010) [PubMed] [Europe PMC] [Abstract]
• endoplasmic reticulum unfolded protein response Source: Reactome
• establishment of viral latency Source: UniProtKBInferred from direct assayⁱ
  • "Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model."
    Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B.
    Apoptosis 15:631-638(2010) [PubMed] [Europe PMC] [Abstract]
• induction of positive chemotaxis Source: UniProtKBInferred from direct assayⁱ
  • Ref.4

    "A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor."
    Kang H., Kim Y.S., Ko J.
    Mol. Endocrinol. 23:1746-1757(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 1), FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING (ISOFORM 1), FUNCTION IN GLUCOCORTICOID-INDUCED TRANSCRIPTIONAL REPRESSION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), TISSUE SPECIFICITY (ISOFORMS 1 AND 2), MUTAGENESIS OF 16-LEU-LEU-17 AND 57-LEU-LEU-58.
• negative regulation of cell cycle Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.9

    "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency."
    Lu R., Misra V.
    J. Virol. 74:934-943(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN HSV-1 INFECTION (MICROBIAL INFECTION), MUTAGENESIS OF TYR-81, SUBCELLULAR LOCATION (ISOFORM 1).
• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• negative regulation of nuclear receptor transcription coactivator activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.4

    "A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor."
    Kang H., Kim Y.S., Ko J.
    Mol. Endocrinol. 23:1746-1757(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 1), FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING (ISOFORM 1), FUNCTION IN GLUCOCORTICOID-INDUCED TRANSCRIPTIONAL REPRESSION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), TISSUE SPECIFICITY (ISOFORMS 1 AND 2), MUTAGENESIS OF 16-LEU-LEU-17 AND 57-LEU-LEU-58.
• positive regulation of calcium ion transport Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
    Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
    FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING, INTERACTION WITH CCR1.
• positive regulation of cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
    Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
    FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING, INTERACTION WITH CCR1.
• positive regulation of deacetylase activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.4

    "A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor."
    Kang H., Kim Y.S., Ko J.
    Mol. Endocrinol. 23:1746-1757(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 1), FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING (ISOFORM 1), FUNCTION IN GLUCOCORTICOID-INDUCED TRANSCRIPTIONAL REPRESSION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), TISSUE SPECIFICITY (ISOFORMS 1 AND 2), MUTAGENESIS OF 16-LEU-LEU-17 AND 57-LEU-LEU-58.
• positive regulation of defense response to virus by host Source: UniProtKBInferred from direct assayⁱ
  • "Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model."
    Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B.
    Apoptosis 15:631-638(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of monocyte chemotaxis Source: UniProtKBInferred from direct assayⁱ
  • Ref.18

    "Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1."
    Jang S.W., Kim Y.S., Kim Y.R., Sung H.J., Ko J.
    J. Biol. Chem. 282:11092-11100(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING, INDUCTION.
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."
    Lu R., Yang P., O'Hare P., Misra V.
    Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), DNA-BINDING (ISOFORM 1), INTERACTION WITH HCFC1 (ISOFORM 1), TISSUE SPECIFICITY.
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.18

    "Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1."
    Jang S.W., Kim Y.S., Kim Y.R., Sung H.J., Ko J.
    J. Biol. Chem. 282:11092-11100(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING, INDUCTION.
  • Ref.14

    "Luman is capable of binding and activating transcription from the unfolded protein response element."
    DenBoer L.M., Hardy-Smith P.W., Hogan M.R., Cockram G.P., Audas T.E., Lu R.
    Biochem. Biophys. Res. Commun. 331:113-119(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, INDUCTION.
  • "Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model."
    Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B.
    Apoptosis 15:631-638(2010) [PubMed] [Europe PMC] [Abstract]
  • "Sustained rolling of microparticles in shear flow over an electrostatically patchy surface."
    Kalasin S., Santore M.M.
    Langmuir 26:2317-2324(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
• regulation of cell growth Source: UniProtKBInferred from direct assayⁱ
  • "Sustained rolling of microparticles in shear flow over an electrostatically patchy surface."
    Kalasin S., Santore M.M.
    Langmuir 26:2317-2324(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.3

    "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation."
    Jin D.-Y., Wang H.-L., Zhou Y., Chun A.C.S., Kibler K.V., Hou Y.-D., Kung H.-F., Jeang K.-T.
    EMBO J. 19:729-740(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION IN CELL PROLIFERATION (MICROBIAL INFECTION), HOMODIMERIZATION, INTERACTION WITH HCV CORE PROTEIN (MICROBIAL INFECTION), DNA-BINDING, SUBCELLULAR LOCATION.
• release from viral latency Source: UniProtKBInferred from direct assayⁱ
  • "Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model."
    Almonte-Becerril M., Navarro-Garcia F., Gonzalez-Robles A., Vega-Lopez M.A., Lavalle C., Kouri J.B.
    Apoptosis 15:631-638(2010) [PubMed] [Europe PMC] [Abstract]
• response to endoplasmic reticulum stress Source: UniProtKBInferred from direct assayⁱ
  • Ref.17

    "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
    Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
    Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN THE UNFOLDED PROTEIN RESPONSE, DNA-BINDING, GLYCOSYLATION, PROTEOLYTIC PROCESSING, INDUCTION.
  • Ref.20

    "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response."
    Audas T.E., Li Y., Liang G., Lu R.
    Mol. Cell. Biol. 28:3952-3966(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH CREBRF, PROTEOLYTIC PROCESSING, INDUCTION, SUBCELLULAR LOCATION.
• transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."
    Lu R., Yang P., O'Hare P., Misra V.
    Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), DNA-BINDING (ISOFORM 1), INTERACTION WITH HCFC1 (ISOFORM 1), TISSUE SPECIFICITY.
• viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cAMP response element binding protein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."
    Lu R., Yang P., O'Hare P., Misra V.
    Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), DNA-BINDING (ISOFORM 1), INTERACTION WITH HCFC1 (ISOFORM 1), TISSUE SPECIFICITY.
• CCR1 chemokine receptor binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.13

    "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
    Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
    FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN LKN-1-STIMULATED CHEMOTAXIS SIGNALING, INTERACTION WITH CCR1.
• protein dimerization activity Source: UniProtKBTraceable author statementⁱ
  • Ref.9

    "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency."
    Lu R., Misra V.
    J. Virol. 74:934-943(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN HSV-1 INFECTION (MICROBIAL INFECTION), MUTAGENESIS OF TYR-81, SUBCELLULAR LOCATION (ISOFORM 1).
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation."
    Jin D.-Y., Wang H.-L., Zhou Y., Chun A.C.S., Kibler K.V., Hou Y.-D., Kung H.-F., Jeang K.-T.
    EMBO J. 19:729-740(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION IN CELL PROLIFERATION (MICROBIAL INFECTION), HOMODIMERIZATION, INTERACTION WITH HCV CORE PROTEIN (MICROBIAL INFECTION), DNA-BINDING, SUBCELLULAR LOCATION.
  • "Sustained rolling of microparticles in shear flow over an electrostatically patchy surface."
    Kalasin S., Santore M.M.
    Langmuir 26:2317-2324(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV 
        60         70         80         90        100
DDLLCSLLSP PASLNILSSS NPCLVHHDHT YSLPRETVSM DLESESCRKE 
       110        120        130        140        150
GTQMTPQHME ELAEQEIARL VLTDEEKSLL EKEGLILPET LPLTKTEEQI 
       160        170        180        190        200
LKRVRRKIRN KRSAQESRRK KKVYVGGLES RVLKYTAQNM ELQNKVQLLE 
       210        220        230        240        250
EQNLSLLDQL RKLQAMVIEI SNKTSSSSTC ILVLLVSFCL LLVPAMYSSD 
       260        270        280        290        300
TRGSLPAEHG VLSRQLRALP SEDPYQLELP ALQSEVPKDS THQWLDGSDC 
       310        320        330        340        350
VLQAPGNTSC LLHYMPQAPS AEPPLEWPFP DLFSEPLCRG PILPLQANLT 
       360        370 
RKGGWLPTGS PSVILQDRYS G                                

        10         20         30         40         50
MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV 
        60         70         80         90        100
DDLLCSLLSP PASLNILSSS NPCLVHHDHT YSLPRETVSM DLESESCRKE 
       110        120        130        140        150
GTQMTPQHME ELAEQEIARL VLTDEEKSLL EKEGLILPET LPLTKTEEQI 
       160        170        180        190        200
LKRVRRKIRN KRSAQESRRK KKVYVGGLES RVLKYTAQNM ELQNKVQLLE 
       210        220        230        240        250
EQNLSLLDQL RKLQAMVIEI SNKTSSSSMY SSDTRGSLPA EHGVLSRQLR 
       260        270        280        290        300
ALPSEDPYQL ELPALQSEVP KDSTHQWLDG SDCVLQAPGN TSCLLHYMPQ 
       310        320        330        340        350
APSAEPPLEW PFPDLFSEPL CRGPILPLQA NLTRKGGWLP TGSPSVILQD 

RYSG                                                   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 9
   Human chromosome 9: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families