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Protein

Sodium/nucleoside cotransporter 2

Gene

SLC28A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Enzyme regulationi

Inhibited by formycin B.

GO - Molecular functioni

  • nucleoside:sodium symporter activity Source: GO_Central
  • purine nucleoside transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • nucleobase-containing compound metabolic process Source: ProtInc
  • purine nucleoside transmembrane transport Source: ProtInc

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Protein family/group databases

TCDBi2.A.41.2.4 the concentrative nucleoside transporter (cnt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 2
Alternative name(s):
Concentrative nucleoside transporter 2
Short name:
CNT 2
Short name:
hCNT2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside co-transporter
Short name:
SPNT
Solute carrier family 28 member 2
Gene namesi
Name:SLC28A2
Synonyms:CNT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137860.11
HGNCiHGNC:11002 SLC28A2
MIMi606208 gene
neXtProtiNX_O43868

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei104 – 123HelicalSequence analysisAdd BLAST20
Transmembranei148 – 166HelicalSequence analysisAdd BLAST19
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei295 – 314HelicalSequence analysisAdd BLAST20
Transmembranei336 – 355HelicalSequence analysisAdd BLAST20
Transmembranei362 – 381HelicalSequence analysisAdd BLAST20
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9153
OpenTargetsiENSG00000137860
PharmGKBiPA386

Chemistry databases

ChEMBLiCHEMBL5780
DrugBankiDB01033 Mercaptopurine
GuidetoPHARMACOLOGYi1115

Polymorphism and mutation databases

BioMutaiSLC28A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704501 – 658Sodium/nucleoside cotransporter 2Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO43868
PeptideAtlasiO43868
PRIDEiO43868
ProteomicsDBi49214

PTM databases

CarbonylDBiO43868
iPTMnetiO43868
PhosphoSitePlusiO43868

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.

Gene expression databases

BgeeiENSG00000137860
CleanExiHS_SLC28A2
ExpressionAtlasiO43868 baseline and differential
GenevisibleiO43868 HS

Organism-specific databases

HPAiHPA046068
HPA055623

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315006

Chemistry databases

BindingDBiO43868

Structurei

3D structure databases

ProteinModelPortaliO43868
SMRiO43868
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3747 Eukaryota
COG1972 LUCA
GeneTreeiENSGT00390000016025
HOGENOMiHOG000267658
HOVERGENiHBG054073
InParanoidiO43868
KOiK11536
OMAiVFMMGVE
OrthoDBiEOG091G05D5
PhylomeDBiO43868
TreeFamiTF314131

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PTHR10590:SF11 PTHR10590:SF11, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

Sequencei

Sequence statusi: Complete.

O43868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL
60 70 80 90 100
GPSTYQRRSR WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN
110 120 130 140 150
FQRALALFVI TCLVIFVLVH SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV
160 170 180 190 200
FAGVSLVGLI LWLALDTAQR PEQLIPFAGI CMFILILFAC SKHHSAVSWR
210 220 230 240 250
TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT VAGSSFVFGD
260 270 280 290 300
TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA
310 320 330 340 350
TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG
360 370 380 390 400
AFIAFGVDAS SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG
410 420 430 440 450
KERNVLEAAS NGAVDAIGLA TNVAANLIAF LAVLAFINAA LSWLGELVDI
460 470 480 490 500
QGLTFQVICS YLLRPMVFMM GVEWTDCPMV AEMVGIKFFI NEFVAYQQLS
510 520 530 540 550
QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS SIGITLGGLT
560 570 580 590 600
SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN
610 620 630 640 650
TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG

FYNNTVCA
Length:658
Mass (Da):71,926
Last modified:October 17, 2006 - v2
Checksum:i273545EE75E0D663
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03681712L → P1 PublicationCorresponds to variant dbSNP:rs567096708Ensembl.1
Natural variantiVAR_02463922P → L2 PublicationsCorresponds to variant dbSNP:rs11854484Ensembl.1
Natural variantiVAR_02464075S → R3 PublicationsCorresponds to variant dbSNP:rs1060896Ensembl.1
Natural variantiVAR_036818142R → H1 PublicationCorresponds to variant dbSNP:rs115740452Ensembl.1
Natural variantiVAR_022001163L → W2 PublicationsCorresponds to variant dbSNP:rs2271437Ensembl.1
Natural variantiVAR_036819172E → D1 PublicationCorresponds to variant dbSNP:rs113624548Ensembl.1
Natural variantiVAR_024641245S → T1 PublicationCorresponds to variant dbSNP:rs10519020Ensembl.1
Natural variantiVAR_024642355F → S1 PublicationCorresponds to variant dbSNP:rs17215633Ensembl.1
Natural variantiVAR_036820385E → K1 PublicationCorresponds to variant dbSNP:rs376327143Ensembl.1
Natural variantiVAR_024643462L → F1 PublicationCorresponds to variant dbSNP:rs17222057Ensembl.1
Natural variantiVAR_028724509G → E. Corresponds to variant dbSNP:rs9635306Ensembl.1
Natural variantiVAR_036821612M → T1 PublicationCorresponds to variant dbSNP:rs373539209Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84392 mRNA Translation: AAC51930.1
AF036109 mRNA Translation: AAB88539.1
AK291974 mRNA Translation: BAF84663.1
BC093737 mRNA Translation: AAH93737.1
CCDSiCCDS10121.1
RefSeqiNP_004203.2, NM_004212.3
XP_011520500.1, XM_011522198.2
UniGeneiHs.367833

Genome annotation databases

EnsembliENST00000347644; ENSP00000315006; ENSG00000137860
GeneIDi9153
KEGGihsa:9153
UCSCiuc001zva.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS28A2_HUMAN
AccessioniPrimary (citable) accession number: O43868
Secondary accession number(s): A8K7F9, O43239, Q52LZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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