CD5L

Functionⁱ

Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).By similarity5 Publications

GO - Molecular functionⁱ

scavenger receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 9045627
immune system process Source: UniProtKB-KW
inflammatory response Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Immunity, Inflammatory response

Biological process

Apoptosis, Immunity, Inflammatory response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD5 antigen-like Alternative name(s): Apoptosis inhibitor expressed by macrophages1 Publication Short name: hAIM1 Publication CT-21 Publication IgM-associated peptide1 Publication SP-alpha1 Publication
Gene namesⁱ	Name:CD5L Synonyms:API6 ORF Names:UNQ203/PRO2291 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000073754.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1690 CD5L
MIMⁱ	602592 gene
neXtProtⁱ	NX_O43866

Keywords - Cellular componentⁱ

Cytoplasm, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	123	S → A: No effect; when associated with 129-A--A-132. 1 Publication		1
Mutagenesisⁱ	129 – 132	SSFS → AAFA: No effect; when associated with A-123. 1 Publication		4

Organism-specific databases

DisGeNET More...DisGeNETⁱ	922
Open Targets More...OpenTargetsⁱ	ENSG00000073754
PharmGKBⁱ	PA26229

Polymorphism and mutation databases

BioMutaⁱ	CD5L

BioMutaⁱ

CD5L

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	3 PublicationsAdd BLAST		19
ChainⁱPRO_0000033225	20 – 347	CD5 antigen-likeAdd BLAST		328

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	33 ↔ 67	PROSITE-ProRule annotation
Disulfide bondⁱ	49 ↔ 114	PROSITE-ProRule annotation
Disulfide bondⁱ	62 ↔ 124	PROSITE-ProRule annotation
Disulfide bondⁱ	96 ↔ 106	PROSITE-ProRule annotation
Disulfide bondⁱ	163 ↔ 228	PROSITE-ProRule annotation
Disulfide bondⁱ	176 ↔ 238	PROSITE-ProRule annotation
Disulfide bondⁱ	208 ↔ 218	PROSITE-ProRule annotation
Disulfide bondⁱ	253 ↔ 287	PROSITE-ProRule annotation
Disulfide bondⁱ	269 ↔ 335	PROSITE-ProRule annotation
Disulfide bondⁱ	282 ↔ 345	PROSITE-ProRule annotation
Disulfide bondⁱ	315 ↔ 325	PROSITE-ProRule annotation

Post-translational modificationⁱ

Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605).1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O43866
PeptideAtlas More...PeptideAtlasⁱ	O43866
PRIDEⁱ	O43866
ProteomicsDBⁱ	49213

PTM databases

iPTMnetⁱ	O43866
PhosphoSitePlusⁱ	O43866

Expressionⁱ

Tissue specificityⁱ

Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000073754 Expressed in 61 organ(s), highest expression level in spleen
CleanExⁱ	HS_CD5L
Genevisibleⁱ	O43866 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065686 HPA068384

HPAⁱ

HPA065686
HPA068384

Interactionⁱ

Subunit structureⁱ

Interacts with FASN; the interaction is direct (By similarity). Interacts with IgM; protecting CD5L from renal excretion and leading to increased CD5L levels in circulating blood (PubMed:8034987, PubMed:24804991).By similarity2 Publications

Protein-protein interaction databases

IntActⁱ	O43866, 7 interactors
STRINGⁱ	9606.ENSP00000357156

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43866
SMRⁱ	O43866
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 125	SRCR 1PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	138 – 239	SRCR 2PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	244 – 346	SRCR 3PROSITE-ProRule annotationAdd BLAST	103

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IKHN Eukaryota ENOG4110209 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140803
HOGENOMⁱ	HOG000290652
HOVERGENⁱ	HBG031373
InParanoidⁱ	O43866
OMAⁱ	YHGEDAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	O43866
TreeFamⁱ	TF329295

Family and domain databases

Gene3Dⁱ	3.10.250.10, 3 hits
InterProⁱ	View protein in InterPro IPR001190 SRCR IPR017448 SRCR-like_dom IPR036772 SRCR-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00530 SRCR, 3 hits
PRINTSⁱ	PR00258 SPERACTRCPTR
SMARTⁱ	View protein in SMART SM00202 SR, 3 hits
SUPFAMⁱ	SSF56487 SSF56487, 3 hits
PROSITEⁱ	View protein in PROSITE PS00420 SRCR_1, 2 hits PS50287 SRCR_2, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O43866-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD 
        60         70         80         90        100
DGWDIKDVAV LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE 
       110        120        130        140        150
DTLAQCEQEE VYDCSHDEDA GASCENPESS FSPVPEGVRL ADGPGHCKGR 
       160        170        180        190        200
VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG CGRAVLTQKR CNKHAYGRKP 
       210        220        230        240        250
IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED PFDLRLVGGD 
       260        270        280        290        300
NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC 
       310        320        330        340 
YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG

Length:347

Mass (Da):38,088

Last modified:June 1, 1998 - v1

Checksum:ⁱ40A8BE08F9495D83

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	347	G → V in AAQ88858 (PubMed:12975309).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033728	117	D → E. Corresponds to variant dbSNP:rs11537583Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U82812 mRNA Translation: AAB91989.1 AF011429 mRNA Translation: AAD01446.1 AY358494 mRNA Translation: AAQ88858.1 AK292040 mRNA Translation: BAF84729.1 AL139409 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52859.1 BC033586 mRNA Translation: AAH33586.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1171.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001334627.1, NM_001347698.1 NP_005885.1, NM_005894.2
UniGeneⁱ	Hs.134035

Genome annotation databases

Ensemblⁱ	ENST00000368174; ENSP00000357156; ENSG00000073754
GeneIDⁱ	922
KEGGⁱ	hsa:922
UCSC genome browser More...UCSCⁱ	uc001frk.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43866	Uncharacterized protein		PONAB		355	UniRef90_O43866
Uncharacterized protein (Fragment)		MACMU		348
Uncharacterized protein		MACNE		347
Uncharacterized protein		NOMLE		347
CD5 molecule like		GORGO		347
+21

Protein	Similar proteins		Species	Score	Length	Source
O43866	Uncharacterized protein		PONAB		355	UniRef50_O43866
Uncharacterized protein (Fragment)		MACMU		348
CD5 molecule like		GORGO		347
Uncharacterized protein		NOMLE		347
Uncharacterized protein		RHIBE		347
+81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U82812 mRNA Translation: AAB91989.1 AF011429 mRNA Translation: AAD01446.1 AY358494 mRNA Translation: AAQ88858.1 AK292040 mRNA Translation: BAF84729.1 AL139409 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52859.1 BC033586 mRNA Translation: AAH33586.1
CCDSⁱ	CCDS1171.1
RefSeqⁱ	NP_001334627.1, NM_001347698.1 NP_005885.1, NM_005894.2
UniGeneⁱ	Hs.134035

3D structure databases

ProteinModelPortalⁱ	O43866
SMRⁱ	O43866
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O43866, 7 interactors
STRINGⁱ	9606.ENSP00000357156

PTM databases

iPTMnetⁱ	O43866
PhosphoSitePlusⁱ	O43866

Polymorphism and mutation databases

BioMutaⁱ	CD5L

BioMutaⁱ

CD5L

Proteomic databases

PaxDbⁱ	O43866
PeptideAtlasⁱ	O43866
PRIDEⁱ	O43866
ProteomicsDBⁱ	49213

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	922
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368174; ENSP00000357156; ENSG00000073754
GeneIDⁱ	922
KEGGⁱ	hsa:922
UCSCⁱ	uc001frk.5 human

Organism-specific databases

CTDⁱ	922
DisGeNETⁱ	922
EuPathDBⁱ	HostDB:ENSG00000073754.5
GeneCardsⁱ	CD5L
HGNCⁱ	HGNC:1690 CD5L
HPAⁱ	HPA065686 HPA068384
MIMⁱ	602592 gene
neXtProtⁱ	NX_O43866
OpenTargetsⁱ	ENSG00000073754
PharmGKBⁱ	PA26229
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKHN Eukaryota ENOG4110209 LUCA
GeneTreeⁱ	ENSGT00900000140803
HOGENOMⁱ	HOG000290652
HOVERGENⁱ	HBG031373
InParanoidⁱ	O43866
OMAⁱ	YHGEDAS
OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	O43866
TreeFamⁱ	TF329295

Miscellaneous databases

ChiTaRSⁱ	CD5L human
GeneWikiⁱ	CD5L
GenomeRNAiⁱ	922
Protein Ontology More...PROⁱ	PR:O43866
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000073754 Expressed in 61 organ(s), highest expression level in spleen
CleanExⁱ	HS_CD5L
Genevisibleⁱ	O43866 HS

Family and domain databases

Gene3Dⁱ	3.10.250.10, 3 hits
InterProⁱ	View protein in InterPro IPR001190 SRCR IPR017448 SRCR-like_dom IPR036772 SRCR-like_dom_sf
Pfamⁱ	View protein in Pfam PF00530 SRCR, 3 hits
PRINTSⁱ	PR00258 SPERACTRCPTR
SMARTⁱ	View protein in SMART SM00202 SR, 3 hits
SUPFAMⁱ	SSF56487 SSF56487, 3 hits
PROSITEⁱ	View protein in PROSITE PS00420 SRCR_1, 2 hits PS50287 SRCR_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD5L_HUMAN
Accessionⁱ	O43866Primary (citable) accession number: O43866 Secondary accession number(s): A8K7M5, Q6UX63
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	June 1, 1998
	Last modified:	September 12, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - O43866 (CD5L_HUMAN)

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CD5 antigen-like

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ