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Entry version 177 (17 Jun 2020)
Sequence version 4 (25 Nov 2008)
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Protein

Probable phospholipid-transporting ATPase IIB

Gene

ATP9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). EC:7.6.2.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4684-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi874MagnesiumBy similarity1
Metal bindingi878MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837 Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IIB (EC:7.6.2.1)
Alternative name(s):
ATPase class II type 9B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP9B
Synonyms:ATPIIB, NEO1L
ORF Names:HUSSY-20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166377.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13541 ATP9B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614446 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43861

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 146CytoplasmicSequence analysisAdd BLAST146
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei147 – 168HelicalSequence analysisAdd BLAST22
Topological domaini169 – 173ExtracellularSequence analysis5
Transmembranei174 – 196HelicalSequence analysisAdd BLAST23
Topological domaini197 – 380CytoplasmicSequence analysisAdd BLAST184
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 409ExtracellularSequence analysis8
Transmembranei410 – 431HelicalSequence analysisAdd BLAST22
Topological domaini432 – 930CytoplasmicSequence analysisAdd BLAST499
Transmembranei931 – 951HelicalSequence analysisAdd BLAST21
Topological domaini952 – 963ExtracellularSequence analysisAdd BLAST12
Transmembranei964 – 982HelicalSequence analysisAdd BLAST19
Topological domaini983 – 1012CytoplasmicSequence analysisAdd BLAST30
Transmembranei1013 – 1031HelicalSequence analysisAdd BLAST19
Topological domaini1032 – 1038ExtracellularSequence analysis7
Transmembranei1039 – 1061HelicalSequence analysisAdd BLAST23
Topological domaini1062 – 1067CytoplasmicSequence analysis6
Transmembranei1068 – 1088HelicalSequence analysisAdd BLAST21
Topological domaini1089 – 1105ExtracellularSequence analysisAdd BLAST17
Transmembranei1106 – 1130HelicalSequence analysisAdd BLAST25
Topological domaini1131 – 1147CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
374868

Open Targets

More...
OpenTargetsi
ENSG00000166377

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25172

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O43861 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP9B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463771 – 1147Probable phospholipid-transporting ATPase IIBAdd BLAST1147

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43861

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43861

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O43861

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43861

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43861

PeptideAtlas

More...
PeptideAtlasi
O43861

PRoteomics IDEntifications database

More...
PRIDEi
O43861

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49209 [O43861-1]
49210 [O43861-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43861

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43861

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O43861

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166377 Expressed in corpus callosum and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43861 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43861 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166377 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131925, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398076

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O43861 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0210 Eukaryota
ENOG410XPYK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000846_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43861

KEGG Orthology (KO)

More...
KOi
K01530

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSIEQFC

Database of Orthologous Groups

More...
OrthoDBi
587717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43861

TreeFam database of animal gene trees

More...
TreeFami
TF300590

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030355 ATP9B
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...
PANTHERi
PTHR24092 PTHR24092, 1 hit
PTHR24092:SF50 PTHR24092:SF50, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43861-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADQIPLYPV RSAAAAAANR KRAAYYSAAG PRPGADRHSR YQLEDESAHL
60 70 80 90 100
DEMPLMMSEE GFENEESDYH TLPRARIMQR KRGLEWFVCD GWKFLCTSCC
110 120 130 140 150
GWLINICRRK KELKARTVWL GCPEKCEEKH PRNSIKNQKY NVFTFIPGVL
160 170 180 190 200
YEQFKFFLNL YFLVISCSQF VPALKIGYLY TYWAPLGFVL AVTMTREAID
210 220 230 240 250
EFRRFQRDKE VNSQLYSKLT VRGKVQVKSS DIQVGDLIIV EKNQRIPSDM
260 270 280 290 300
VFLRTSEKAG SCFIRTDQLD GETDWKLKVA VSCTQQLPAL GDLFSISAYV
310 320 330 340 350
YAQKPQMDIH SFEGTFTRED SDPPIHESLS IENTLWASTI VASGTVIGVV
360 370 380 390 400
IYTGKETRSV MNTSNPKNKV GLLDLELNRL TKALFLALVA LSIVMVTLQG
410 420 430 440 450
FVGPWYRNLF RFLLLFSYII PISLRVNLDM GKAVYGWMMM KDENIPGTVV
460 470 480 490 500
RTSTIPEELG RLVYLLTDKT GTLTQNEMIF KRLHLGTVSY GADTMDEIQS
510 520 530 540 550
HVRDSYSQMQ SQAGGNNTGS TPLRKAQSSA PKVRKSVSSR IHEAVKAIVL
560 570 580 590 600
CHNVTPVYES RAGVTEETEF AEADQDFSDE NRTYQASSPD EVALVQWTES
610 620 630 640 650
VGLTLVSRDL TSMQLKTPSG QVLSFCILQL FPFTSESKRM GVIVRDESTA
660 670 680 690 700
EITFYMKGAD VAMSPIVQYN DWLEEECGNM AREGLRTLVV AKKALTEEQY
710 720 730 740 750
QDFESRYTQA KLSMHDRSLK VAAVVESLER EMELLCLTGV EDQLQADVRP
760 770 780 790 800
TLEMLRNAGI KIWMLTGDKL ETATCIAKSS HLVSRTQDIH IFRQVTSRGE
810 820 830 840 850
AHLELNAFRR KHDCALVISG DSLEVCLKYY EHEFVELACQ CPAVVCCRCS
860 870 880 890 900
PTQKARIVTL LQQHTGRRTC AIGDGGNDVS MIQAADCGIG IEGKEGKQAS
910 920 930 940 950
LAADFSITQF RHIGRLLMVH GRNSYKRSAA LGQFVMHRGL IISTMQAVFS
960 970 980 990 1000
SVFYFASVPL YQGFLMVGYA TIYTMFPVFS LVLDQDVKPE MAMLYPELYK
1010 1020 1030 1040 1050
DLTKGRSLSF KTFLIWVLIS IYQGGILMYG ALVLFESEFV HVVAISFTAL
1060 1070 1080 1090 1100
ILTELLMVAL TVRTWHWLMV VAEFLSLGCY VSSLAFLNEY FGIGRVSFGA
1110 1120 1130 1140
FLDVAFITTV TFLWKVSAIT VVSCLPLYVL KYLRRKLSPP SYCKLAS
Length:1,147
Mass (Da):129,304
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C3787BF07EFD637
GO
Isoform 2 (identifier: O43861-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1092-1102: Missing.

Show »
Length:1,136
Mass (Da):128,198
Checksum:iEE75E3FF2C930873
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJP9K7EJP9_HUMAN
Probable phospholipid-transporting ...
ATP9B
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL57K7EL57_HUMAN
Probable phospholipid-transporting ...
ATP9B
80Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XUP2F6XUP2_HUMAN
Probable phospholipid-transporting ...
ATP9B
471Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERE0K7ERE0_HUMAN
Probable phospholipid-transporting ...
ATP9B
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DJ94B4DJ94_HUMAN
Probable phospholipid-transporting ...
ATP9B
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQQ5K7EQQ5_HUMAN
Probable phospholipid-transporting ...
ATP9B
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EII3K7EII3_HUMAN
Probable phospholipid-transporting ...
ATP9B
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPH4K7EPH4_HUMAN
Probable phospholipid-transporting ...
ATP9B
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES39K7ES39_HUMAN
Probable phospholipid-transporting ...
ATP9B
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJG1K7EJG1_HUMAN
Probable phospholipid-transporting ...
ATP9B
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti886D → N in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1006R → K in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1020S → I in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1036E → D in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1073E → D in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1095R → K in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1103D → N in AAC05243 (PubMed:9548971).Curated1
Sequence conflicti1131K → N in AAC05243 (PubMed:9548971).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04755739S → G1 PublicationCorresponds to variant dbSNP:rs4078115Ensembl.1
Natural variantiVAR_061037108R → Q. Corresponds to variant dbSNP:rs34938281Ensembl.1
Natural variantiVAR_047558504D → N. Corresponds to variant dbSNP:rs36034863Ensembl.1
Natural variantiVAR_047559732M → L. Corresponds to variant dbSNP:rs585033Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357901092 – 1102Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC023090 Genomic DNA No translation available.
AC099689 Genomic DNA No translation available.
AC104423 Genomic DNA No translation available.
AC125437 Genomic DNA No translation available.
BC125219 mRNA Translation: AAI25220.1
BC125220 mRNA Translation: AAI25221.1
AK097757 mRNA No translation available.
U78978 mRNA Translation: AAC05243.1
AJ006268 mRNA Translation: CAA06934.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12014.1 [O43861-1]
CCDS77202.1 [O43861-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001293014.1, NM_001306085.1 [O43861-2]
NP_940933.3, NM_198531.4 [O43861-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307671; ENSP00000304500; ENSG00000166377 [O43861-2]
ENST00000426216; ENSP00000398076; ENSG00000166377 [O43861-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
374868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374868

UCSC genome browser

More...
UCSCi
uc002lmw.2 human [O43861-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023090 Genomic DNA No translation available.
AC099689 Genomic DNA No translation available.
AC104423 Genomic DNA No translation available.
AC125437 Genomic DNA No translation available.
BC125219 mRNA Translation: AAI25220.1
BC125220 mRNA Translation: AAI25221.1
AK097757 mRNA No translation available.
U78978 mRNA Translation: AAC05243.1
AJ006268 mRNA Translation: CAA06934.1
CCDSiCCDS12014.1 [O43861-1]
CCDS77202.1 [O43861-2]
RefSeqiNP_001293014.1, NM_001306085.1 [O43861-2]
NP_940933.3, NM_198531.4 [O43861-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131925, 2 interactors
STRINGi9606.ENSP00000398076

PTM databases

iPTMnetiO43861
PhosphoSitePlusiO43861
SwissPalmiO43861

Polymorphism and mutation databases

BioMutaiATP9B

Proteomic databases

EPDiO43861
jPOSTiO43861
MassIVEiO43861
MaxQBiO43861
PaxDbiO43861
PeptideAtlasiO43861
PRIDEiO43861
ProteomicsDBi49209 [O43861-1]
49210 [O43861-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23438 10 antibodies

Genome annotation databases

EnsembliENST00000307671; ENSP00000304500; ENSG00000166377 [O43861-2]
ENST00000426216; ENSP00000398076; ENSG00000166377 [O43861-1]
GeneIDi374868
KEGGihsa:374868
UCSCiuc002lmw.2 human [O43861-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
374868
DisGeNETi374868
EuPathDBiHostDB:ENSG00000166377.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP9B
HGNCiHGNC:13541 ATP9B
HPAiENSG00000166377 Low tissue specificity
MIMi614446 gene
neXtProtiNX_O43861
OpenTargetsiENSG00000166377
PharmGKBiPA25172

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0210 Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00940000157071
HOGENOMiCLU_000846_3_1_1
InParanoidiO43861
KOiK01530
OMAiFSIEQFC
OrthoDBi587717at2759
PhylomeDBiO43861
TreeFamiTF300590

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
374868 1 hit in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP9B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
374868
PharosiO43861 Tdark

Protein Ontology

More...
PROi
PR:O43861
RNActiO43861 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166377 Expressed in corpus callosum and 200 other tissues
ExpressionAtlasiO43861 baseline and differential
GenevisibleiO43861 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030355 ATP9B
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF50 PTHR24092:SF50, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP9B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43861
Secondary accession number(s): O60872, Q08AD8, Q08AD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 177 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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