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Protein

EGF-like repeat and discoidin I-like domain-containing protein 3

Gene

EDIL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi119Calcium1
Metal bindingi120Calcium; via carbonyl oxygen1
Metal bindingi122Calcium1
Metal bindingi136Calcium1
Metal bindingi137Calcium; via carbonyl oxygen1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: BHF-UCL
  • integrin binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EGF-like repeat and discoidin I-like domain-containing protein 3
Alternative name(s):
Developmentally-regulated endothelial cell locus 1 protein
Integrin-binding protein DEL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDIL3
Synonyms:DEL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164176.12

Human Gene Nomenclature Database

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HGNCi
HGNC:3173 EDIL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606018 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43854

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10085

Open Targets

More...
OpenTargetsi
ENSG00000164176

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27613

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EDIL3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000752224 – 480EGF-like repeat and discoidin I-like domain-containing protein 3Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 371 Publication
Disulfide bondi31 ↔ 481 Publication
Disulfide bondi50 ↔ 591 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi78 ↔ 891 Publication
Disulfide bondi83 ↔ 1051 Publication
Glycosylationi88O-linked (Fuc...) threonine1 Publication1
Disulfide bondi107 ↔ 1161 Publication
Disulfide bondi123 ↔ 1341 Publication
Disulfide bondi128 ↔ 1431 Publication
Glycosylationi140N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi145 ↔ 1541 Publication
Disulfide bondi158 ↔ 314By similarity
Disulfide bondi301 ↔ 305By similarity
Disulfide bondi319 ↔ 476By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43854

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43854

MaxQB - The MaxQuant DataBase

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MaxQBi
O43854

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43854

PeptideAtlas

More...
PeptideAtlasi
O43854

PRoteomics IDEntifications database

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PRIDEi
O43854

ProteomicsDB human proteome resource

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ProteomicsDBi
49207
49208 [O43854-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43854

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43854

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164176 Expressed in 216 organ(s), highest expression level in Brodmann (1909) area 46

CleanEx database of gene expression profiles

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CleanExi
HS_EDIL3

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43854 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA020415

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115394, 11 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O43854

Protein interaction database and analysis system

More...
IntActi
O43854, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D90X-ray2.60A/B24-157[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43854

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43854

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 60EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini74 – 117EGF-like 2PROSITE-ProRule annotationAdd BLAST44
Domaini119 – 155EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini158 – 314F5/8 type C 1PROSITE-ProRule annotationAdd BLAST157
Domaini319 – 476F5/8 type C 2PROSITE-ProRule annotationAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 98Cell attachment site3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

EGF2 and EGF3 form a rigid rod via an interdomain calcium ion binding site, while the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFBC Eukaryota
ENOG41114BV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236278

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002385

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43854

Identification of Orthologs from Complete Genome Data

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OMAi
CKGDICD

Database of Orthologous Groups

More...
OrthoDBi
441415at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43854

TreeFam database of animal gene trees

More...
TreeFami
TF330156

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.260, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029828 EDIL-3
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf

The PANTHER Classification System

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PANTHERi
PTHR44122:SF3 PTHR44122:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00008 EGF, 2 hits
PF00754 F5_F8_type_C, 2 hits
PF12661 hEGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 3 hits
SM00231 FA58C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O43854-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC
60 70 80 90 100
PDGFTDPNCS SVVEVASDEE EPTSAGPCTP NPCHNGGTCE ISEAYRGDTF
110 120 130 140 150
IGYVCKCPRG FNGIHCQHNI NECEVEPCKN GGICTDLVAN YSCECPGEFM
160 170 180 190 200
GRNCQYKCSG PLGIEGGIIS NQQITASSTH RALFGLQKWY PYYARLNKKG
210 220 230 240 250
LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP EYIKSYKIAY
260 270 280 290 300
SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV
310 320 330 340 350
CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT
360 370 380 390 400
WEPRKARLDK QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG
410 420 430 440 450
HVQFVGSYKL AYSNDGEHWT VYQDEKQRKD KVFQGNFDND THRKNVIDPP
460 470 480
IYARHIRILP WSWYGRITLR SELLGCTEEE
Length:480
Mass (Da):53,765
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7171E23A309FD48
GO
Isoform 2 (identifier: O43854-2) [UniParc]FASTAAdd to basket
Also known as: Short, Z20

The sequence of this isoform differs from the canonical sequence as follows:
     66-66: A → G
     67-76: Missing.

Show »
Length:470
Mass (Da):52,748
Checksum:iEFF139A13FE5337A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16G → S in AAH30828 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05000666A → G in isoform 2. 2 Publications1
Alternative sequenceiVSP_05000767 – 76Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70312 mRNA Translation: AAC02648.1
U70313 mRNA Translation: AAC02649.1
AK312858 mRNA Translation: BAG35710.1
CH471084 Genomic DNA Translation: EAW95917.1
CH471084 Genomic DNA Translation: EAW95918.1
BC030828 mRNA Translation: AAH30828.1
BC053656 mRNA Translation: AAH53656.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4062.1 [O43854-1]
CCDS64195.1 [O43854-2]

NCBI Reference Sequences

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RefSeqi
NP_001265571.1, NM_001278642.1 [O43854-2]
NP_005702.3, NM_005711.4 [O43854-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.482730

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296591; ENSP00000296591; ENSG00000164176 [O43854-1]
ENST00000380138; ENSP00000369483; ENSG00000164176 [O43854-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10085

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10085

UCSC genome browser

More...
UCSCi
uc003kio.3 human [O43854-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70312 mRNA Translation: AAC02648.1
U70313 mRNA Translation: AAC02649.1
AK312858 mRNA Translation: BAG35710.1
CH471084 Genomic DNA Translation: EAW95917.1
CH471084 Genomic DNA Translation: EAW95918.1
BC030828 mRNA Translation: AAH30828.1
BC053656 mRNA Translation: AAH53656.1
CCDSiCCDS4062.1 [O43854-1]
CCDS64195.1 [O43854-2]
RefSeqiNP_001265571.1, NM_001278642.1 [O43854-2]
NP_005702.3, NM_005711.4 [O43854-1]
UniGeneiHs.482730

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D90X-ray2.60A/B24-157[»]
ProteinModelPortaliO43854
SMRiO43854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115394, 11 interactors
ELMiO43854
IntActiO43854, 2 interactors
STRINGi9606.ENSP00000296591

PTM databases

iPTMnetiO43854
PhosphoSitePlusiO43854

Polymorphism and mutation databases

BioMutaiEDIL3

Proteomic databases

EPDiO43854
jPOSTiO43854
MaxQBiO43854
PaxDbiO43854
PeptideAtlasiO43854
PRIDEiO43854
ProteomicsDBi49207
49208 [O43854-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10085
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296591; ENSP00000296591; ENSG00000164176 [O43854-1]
ENST00000380138; ENSP00000369483; ENSG00000164176 [O43854-2]
GeneIDi10085
KEGGihsa:10085
UCSCiuc003kio.3 human [O43854-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10085
DisGeNETi10085
EuPathDBiHostDB:ENSG00000164176.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EDIL3
HGNCiHGNC:3173 EDIL3
HPAiHPA020415
MIMi606018 gene
neXtProtiNX_O43854
OpenTargetsiENSG00000164176
PharmGKBiPA27613

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFBC Eukaryota
ENOG41114BV LUCA
GeneTreeiENSGT00940000158144
HOGENOMiHOG000236278
HOVERGENiHBG002385
InParanoidiO43854
OMAiCKGDICD
OrthoDBi441415at2759
PhylomeDBiO43854
TreeFamiTF330156

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EDIL3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10085

Protein Ontology

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PROi
PR:O43854

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164176 Expressed in 216 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_EDIL3
GenevisibleiO43854 HS

Family and domain databases

CDDicd00057 FA58C, 2 hits
Gene3Di2.60.120.260, 2 hits
InterProiView protein in InterPro
IPR029828 EDIL-3
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR44122:SF3 PTHR44122:SF3, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 2 hits
PF00754 F5_F8_type_C, 2 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 3 hits
SM00231 FA58C, 2 hits
SUPFAMiSSF49785 SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEDIL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43854
Secondary accession number(s): B2R763
, O43855, Q5D094, Q8N610
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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