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UniProtKB - O43852 (CALU_HUMAN)

Entry version 204 (23 Feb 2022)
Sequence version 2 (15 Jul 1999)
Previous versions | rss
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Protein

Calumenin

Gene

CALU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi81 – 921PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi117 – 1282PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi164 – 1753; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi201 – 2124PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi242 – 2535PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi278 – 2896PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43852

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43852

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43852

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calumenin
Alternative name(s):
Crocalbin
IEF SSP 9302
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALU
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1458, CALU

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603420, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43852

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128595

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		813

Open Targets

More...OpenTargetsi		ENSG00000128595

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26047

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43852, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CALU

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000415320 – 315CalumeninAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei65PhosphothreonineCombined sources1
Modified residuei69Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi131N-linked (GlcNAc...) (complex) asparagine2 Publications1
Modified residuei165N6-acetyllysineBy similarity1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43852

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43852

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43852

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43852

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43852

PeptideAtlas

More...PeptideAtlasi		O43852

PRoteomics IDEntifications database

More...PRIDEi		O43852

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		25733
27707
49203 [O43852-1]
49204 [O43852-2]
49205 [O43852-3]
49206 [O43852-4]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O43852-1 [O43852-1]
O43852-2 [O43852-2]
O43852-3 [O43852-3]
O43852-4 [O43852-4]
O43852-5 [O43852-5]
O43852-6 [O43852-6]
O43852-8 [O43852-8]
O43852-9 [O43852-9]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		O43852

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1062, 43 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43852, 3 sites, 45 N-linked glycans (1 site), 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43852

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O43852

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43852

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43852

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128595, Expressed in stromal cell of endometrium and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43852, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43852, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128595, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GGCX.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107263, 276 interactors

Protein interaction database and analysis system

More...IntActi		O43852, 87 interactors

Molecular INTeraction database

More...MINTi		O43852

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000438248

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43852, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		O43852

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 103EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini104 – 139EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini188 – 223EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini229 – 264EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini265 – 300EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi312 – 315Prevents secretion from ERBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4223, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222360

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044718_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43852

Database of Orthologous Groups

More...OrthoDBi		909079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43852

TreeFam database of animal gene trees

More...TreeFami		TF314849

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027239, Calumenin
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

The PANTHER Classification System

More...PANTHERi		PTHR10827:SF76, PTHR10827:SF76, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13202, EF-hand_5, 2 hits
PF13833, EF-hand_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (15+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 15 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O43852-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD 
        60         70         80         90        100
AFLGAEEAKT FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA 
       110        120        130        140        150
QKRWIYEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK 
       160        170        180        190        200
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI 
       210        220        230        240        250
DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF RDKNRDGKMD 
       260        270        280        290        300
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 
       310 
QATDFGEALV RHDEF
Length:315
Mass (Da):37,107
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25BAE5A99B527375
GO
Isoform 2 (identifier: O43852-2) [UniParc]FASTAAdd to basket
Also known as: Crocalbin

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Show »
Length:315
Mass (Da):37,135
Checksum:iE1BF415B25076676
GO
Isoform 3 (identifier: O43852-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM

Show »
Length:323
Mass (Da):38,051
Checksum:i0357815A65B4C364
GO
Isoform 4 (identifier: O43852-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Show »
Length:323
Mass (Da):38,079
Checksum:iC75225A8DBE1D667
GO
Isoform 5 (identifier: O43852-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-249: Missing.

Show »
Length:229
Mass (Da):26,892
Checksum:iB73499A59B44F6D0
GO
Isoform 6 (identifier: O43852-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-275: Missing.

Show »
Length:265
Mass (Da):30,957
Checksum:i853B18C78BFD2FD5
GO
Isoform 7 (identifier: O43852-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     154-161: VRDERRFK → GILMSRNG
     162-315: Missing.

Show »
Length:161
Mass (Da):18,789
Checksum:i2F30CCD0362501B9
GO
Isoform 8 (identifier: O43852-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     172-285: Missing.

Show »
Length:201
Mass (Da):23,519
Checksum:i031A48109B3A5721
GO
Isoform 9 (identifier: O43852-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-254: Missing.

Show »
Length:154
Mass (Da):17,639
Checksum:iC01A8709FEEEE48F
GO
Isoform 10 (identifier: O43852-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR

Show »
Length:224
Mass (Da):26,326
Checksum:iA58B5C4DF48D5C56
GO
Isoform 11 (identifier: O43852-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-170: KDGDLI → RARAVC
     171-315: Missing.

Show »
Length:170
Mass (Da):19,993
Checksum:iDE2FFE0A2E51C11B
GO
Isoform 12 (identifier: O43852-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-315: Missing.

Show »
Length:74
Mass (Da):8,511
Checksum:i24C00B317B5508DE
GO
Isoform 13 (identifier: O43852-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: D → E
     140-315: Missing.

Show »
Length:139
Mass (Da):16,291
Checksum:iDC485712A52F6454
GO
Isoform 14 (identifier: O43852-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     139-139: D → E
     140-315: Missing.

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Length:147
Mass (Da):17,235
Checksum:i895C953C9569567E
GO
Isoform 15 (identifier: O43852-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:164
Mass (Da):19,455
Checksum:iE53F4259F8265B8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y875H0Y875_HUMAN
Calumenin
CALU
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48D → G in ADG45013 (Ref. 4) Curated1
Sequence conflicti84K → R in ADG45007 (Ref. 4) Curated1
Sequence conflicti90V → A in ADG45010 (Ref. 4) Curated1
Sequence conflicti117D → G in ADG45007 (Ref. 4) Curated1
Sequence conflicti118L → H in ADG45011 (Ref. 4) Curated1
Sequence conflicti147F → S in ADG45012 (Ref. 4) Curated1
Sequence conflicti188M → V in ADG45015 (Ref. 4) Curated1
Sequence conflicti207F → L in AAB97725 (PubMed:9675259).Curated1
Sequence conflicti232T → S in ADG45015 (Ref. 4) Curated1
Sequence conflicti267E → V in CAG46634 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0220514R → Q1 PublicationCorresponds to variant dbSNP:rs2290228Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0459391 – 151Missing in isoform 15. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_0435701M → MKETDLIIM in isoform 3, isoform 4 and isoform 14. 2 Publications1
Alternative sequenceiVSP_04594075 – 315Missing in isoform 12. 1 PublicationAdd BLAST241
Alternative sequenceiVSP_00731775 – 137KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8. 3 PublicationsAdd BLAST63
Alternative sequenceiVSP_04594194 – 254Missing in isoform 9. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_045942139D → E in isoform 13 and isoform 14. 1 Publication1
Alternative sequenceiVSP_045943140 – 315Missing in isoform 13 and isoform 14. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_045944154 – 161VRDERRFK → GILMSRNG in isoform 7. 1 Publication8
Alternative sequenceiVSP_045945162 – 315Missing in isoform 7. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_045946164 – 249Missing in isoform 5. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_045947165 – 170KDGDLI → RARAVC in isoform 11. 1 Publication6
Alternative sequenceiVSP_045948171 – 315Missing in isoform 11. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_045949172 – 285Missing in isoform 8. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_045950216 – 315DMYSH…RHDEF → WQAYQGGDR in isoform 10. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_045951226 – 275Missing in isoform 6. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U67280 mRNA Translation: AAB97725.1
AF013759 mRNA Translation: AAC17216.1
AF345637 mRNA Translation: AAK72908.1
HM002604 mRNA Translation: ADG45004.1
HM002605 mRNA Translation: ADG45005.1
HM002606 mRNA Translation: ADG45006.1
HM002607 mRNA Translation: ADG45007.1
HM002608 mRNA Translation: ADG45008.1
HM002609 mRNA Translation: ADG45009.1
HM002610 mRNA Translation: ADG45010.1
HM002611 mRNA Translation: ADG45011.1
HM002612 mRNA Translation: ADG45012.1
HM002613 mRNA Translation: ADG45013.1
HM002614 mRNA Translation: ADG45014.1
HM002615 mRNA Translation: ADG45015.1
HM002616 mRNA Translation: ADG45016.1
AK056338 mRNA Translation: BAG51681.1
CR541835 mRNA Translation: CAG46634.1
AC024952 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83679.1
BC013383 mRNA Translation: AAH13383.1
AF257659 mRNA Translation: AAF76141.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47703.1 [O43852-2]
CCDS56506.1 [O43852-3]
CCDS56507.1 [O43852-4]
CCDS56508.1 [O43852-10]
CCDS5805.1 [O43852-1]

NCBI Reference Sequences

More...RefSeqi		NP_001124146.1, NM_001130674.2 [O43852-2]
NP_001186600.1, NM_001199671.1 [O43852-3]
NP_001186601.1, NM_001199672.1 [O43852-4]
NP_001186602.1, NM_001199673.1 [O43852-10]
NP_001210.1, NM_001219.4 [O43852-1]
XP_016868148.1, XM_017012659.1 [O43852-15]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249364; ENSP00000249364; ENSG00000128595
ENST00000449187; ENSP00000408838; ENSG00000128595 [O43852-2]
ENST00000479257; ENSP00000420381; ENSG00000128595 [O43852-3]
ENST00000535011; ENSP00000442110; ENSG00000128595 [O43852-10]
ENST00000542996; ENSP00000438248; ENSG00000128595 [O43852-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:813

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000249364.9; ENSP00000249364.4; NM_001219.5; NP_001210.1

UCSC genome browser

More...UCSCi		uc003vnr.4, human [O43852-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67280 mRNA Translation: AAB97725.1
AF013759 mRNA Translation: AAC17216.1
AF345637 mRNA Translation: AAK72908.1
HM002604 mRNA Translation: ADG45004.1
HM002605 mRNA Translation: ADG45005.1
HM002606 mRNA Translation: ADG45006.1
HM002607 mRNA Translation: ADG45007.1
HM002608 mRNA Translation: ADG45008.1
HM002609 mRNA Translation: ADG45009.1
HM002610 mRNA Translation: ADG45010.1
HM002611 mRNA Translation: ADG45011.1
HM002612 mRNA Translation: ADG45012.1
HM002613 mRNA Translation: ADG45013.1
HM002614 mRNA Translation: ADG45014.1
HM002615 mRNA Translation: ADG45015.1
HM002616 mRNA Translation: ADG45016.1
AK056338 mRNA Translation: BAG51681.1
CR541835 mRNA Translation: CAG46634.1
AC024952 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83679.1
BC013383 mRNA Translation: AAH13383.1
AF257659 mRNA Translation: AAF76141.1
CCDSiCCDS47703.1 [O43852-2]
CCDS56506.1 [O43852-3]
CCDS56507.1 [O43852-4]
CCDS56508.1 [O43852-10]
CCDS5805.1 [O43852-1]
RefSeqiNP_001124146.1, NM_001130674.2 [O43852-2]
NP_001186600.1, NM_001199671.1 [O43852-3]
NP_001186601.1, NM_001199672.1 [O43852-4]
NP_001186602.1, NM_001199673.1 [O43852-10]
NP_001210.1, NM_001219.4 [O43852-1]
XP_016868148.1, XM_017012659.1 [O43852-15]

3D structure databases

SASBDBiO43852
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi107263, 276 interactors
IntActiO43852, 87 interactors
MINTiO43852
STRINGi9606.ENSP00000438248

PTM databases

GlyConnecti1062, 43 N-Linked glycans (1 site)
GlyGeniO43852, 3 sites, 45 N-linked glycans (1 site), 2 O-linked glycans (2 sites)
iPTMnetiO43852
MetOSiteiO43852
PhosphoSitePlusiO43852
SwissPalmiO43852

Genetic variation databases

BioMutaiCALU

2D gel databases

DOSAC-COBS-2DPAGEiO43852

Proteomic databases

EPDiO43852
jPOSTiO43852
MassIVEiO43852
MaxQBiO43852
PaxDbiO43852
PeptideAtlasiO43852
PRIDEiO43852
ProteomicsDBi25733
27707
49203 [O43852-1]
49204 [O43852-2]
49205 [O43852-3]
49206 [O43852-4]
TopDownProteomicsiO43852-1 [O43852-1]
O43852-2 [O43852-2]
O43852-3 [O43852-3]
O43852-4 [O43852-4]
O43852-5 [O43852-5]
O43852-6 [O43852-6]
O43852-8 [O43852-8]
O43852-9 [O43852-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1219, 270 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		813

Genome annotation databases

EnsembliENST00000249364; ENSP00000249364; ENSG00000128595
ENST00000449187; ENSP00000408838; ENSG00000128595 [O43852-2]
ENST00000479257; ENSP00000420381; ENSG00000128595 [O43852-3]
ENST00000535011; ENSP00000442110; ENSG00000128595 [O43852-10]
ENST00000542996; ENSP00000438248; ENSG00000128595 [O43852-4]
GeneIDi813
KEGGihsa:813
MANE-SelectiENST00000249364.9; ENSP00000249364.4; NM_001219.5; NP_001210.1
UCSCiuc003vnr.4, human [O43852-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		813
DisGeNETi813

GeneCards: human genes, protein and diseases

More...GeneCardsi		CALU
HGNCiHGNC:1458, CALU
HPAiENSG00000128595, Low tissue specificity
MIMi603420, gene
neXtProtiNX_O43852
OpenTargetsiENSG00000128595
PharmGKBiPA26047
VEuPathDBiHostDB:ENSG00000128595

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4223, Eukaryota
GeneTreeiENSGT01010000222360
HOGENOMiCLU_044718_0_1_1
InParanoidiO43852
OrthoDBi909079at2759
PhylomeDBiO43852
TreeFamiTF314849

Enzyme and pathway databases

PathwayCommonsiO43852
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiO43852
SIGNORiO43852

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		813, 7 hits in 1045 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CALU, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CALU_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		813
PharosiO43852, Tbio

Protein Ontology

More...PROi		PR:O43852
RNActiO43852, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128595, Expressed in stromal cell of endometrium and 249 other tissues
ExpressionAtlasiO43852, baseline and differential
GenevisibleiO43852, HS

Family and domain databases

InterProiView protein in InterPro
IPR027239, Calumenin
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PANTHERiPTHR10827:SF76, PTHR10827:SF76, 1 hit
PfamiView protein in Pfam
PF13202, EF-hand_5, 2 hits
PF13833, EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 4 hits
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCALU_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43852
Secondary accession number(s): B3KPG9
, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52, D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, D6QS58, D6QS59, F5H1Q9, F5H879, O60456, Q6FHB9, Q96RL3, Q9NR43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: February 23, 2022
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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