UniProtKB - O43852 (CALU_HUMAN)
Calumenin
CALU
Functioni
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 81 – 92 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 117 – 128 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 164 – 175 | 3; possibly ancestralPROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 201 – 212 | 4PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 242 – 253 | 5PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 278 – 289 | 6PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | O43852 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | O43852 |
SIGNORi | O43852 |
Names & Taxonomyi
Protein namesi | Recommended name: CalumeninAlternative name(s): Crocalbin IEF SSP 9302 |
Gene namesi | Name:CALU |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1458, CALU |
MIMi | 603420, gene |
neXtProti | NX_O43852 |
VEuPathDBi | HostDB:ENSG00000128595 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 1 Publication
Extracellular region or secreted
- Secreted Curated
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Other locations
- Melanosome 1 Publication
- Sarcoplasmic reticulum lumen Curated
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: ProtInc
Other locations
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 813 |
OpenTargetsi | ENSG00000128595 |
PharmGKBi | PA26047 |
Miscellaneous databases
Pharosi | O43852, Tbio |
Genetic variation databases
BioMutai | CALU |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000004153 | 20 – 315 | CalumeninAdd BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 65 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 69 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 131 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Modified residuei | 165 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 254 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 261 | PhosphoserineCombined sources | 1 | |
Modified residuei | 277 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O43852 |
jPOSTi | O43852 |
MassIVEi | O43852 |
MaxQBi | O43852 |
PaxDbi | O43852 |
PeptideAtlasi | O43852 |
PRIDEi | O43852 |
ProteomicsDBi | 25733 27707 49203 [O43852-1] 49204 [O43852-2] 49205 [O43852-3] 49206 [O43852-4] |
TopDownProteomicsi | O43852-1 [O43852-1] O43852-2 [O43852-2] O43852-3 [O43852-3] O43852-4 [O43852-4] O43852-5 [O43852-5] O43852-6 [O43852-6] O43852-8 [O43852-8] O43852-9 [O43852-9] |
2D gel databases
DOSAC-COBS-2DPAGEi | O43852 |
PTM databases
GlyConnecti | 1062, 43 N-Linked glycans (1 site) |
GlyGeni | O43852, 3 sites, 45 N-linked glycans (1 site), 2 O-linked glycans (2 sites) |
iPTMneti | O43852 |
MetOSitei | O43852 |
PhosphoSitePlusi | O43852 |
SwissPalmi | O43852 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000128595, Expressed in stromal cell of endometrium and 249 other tissues |
ExpressionAtlasi | O43852, baseline and differential |
Genevisiblei | O43852, HS |
Organism-specific databases
HPAi | ENSG00000128595, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with GGCX.
By similarityBinary interactionsi
O43852
With | #Exp. | IntAct |
---|---|---|
UBQLN1 - isoform 2 [Q9UMX0-2] | 3 | EBI-1171069,EBI-10173939 |
Isoform 1 [O43852-1]
With | #Exp. | IntAct |
---|---|---|
CFTR [P13569] | 2 | EBI-5280679,EBI-349854 |
Isoform 3 [O43852-3]
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-11536607,EBI-77613 |
Protein-protein interaction databases
BioGRIDi | 107263, 276 interactors |
IntActi | O43852, 87 interactors |
MINTi | O43852 |
STRINGi | 9606.ENSP00000438248 |
Miscellaneous databases
RNActi | O43852, protein |
Structurei
3D structure databases
SASBDBi | O43852 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 103 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 104 – 139 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 151 – 186 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 188 – 223 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 229 – 264 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 265 – 300 | EF-hand 6PROSITE-ProRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 312 – 315 | Prevents secretion from ERBy similarity | 4 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG4223, Eukaryota |
GeneTreei | ENSGT01010000222360 |
HOGENOMi | CLU_044718_0_1_1 |
InParanoidi | O43852 |
OrthoDBi | 909079at2759 |
PhylomeDBi | O43852 |
TreeFami | TF314849 |
Family and domain databases
InterProi | View protein in InterPro IPR027239, Calumenin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR10827:SF76, PTHR10827:SF76, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 2 hits PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 6 hits |
s (15+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 15 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 15 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD
60 70 80 90 100
AFLGAEEAKT FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA
110 120 130 140 150
QKRWIYEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK
160 170 180 190 200
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI
210 220 230 240 250
DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF RDKNRDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
310
QATDFGEALV RHDEF
The sequence of this isoform differs from the canonical sequence as follows:
216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR
The sequence of this isoform differs from the canonical sequence as follows:
165-170: KDGDLI → RARAVC
171-315: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
75-315: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
139-139: D → E
140-315: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MKETDLIIM
139-139: D → E
140-315: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-151: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y875 | H0Y875_HUMAN | Calumenin | CALU | 147 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | D → G in ADG45013 (Ref. 4) Curated | 1 | |
Sequence conflicti | 84 | K → R in ADG45007 (Ref. 4) Curated | 1 | |
Sequence conflicti | 90 | V → A in ADG45010 (Ref. 4) Curated | 1 | |
Sequence conflicti | 117 | D → G in ADG45007 (Ref. 4) Curated | 1 | |
Sequence conflicti | 118 | L → H in ADG45011 (Ref. 4) Curated | 1 | |
Sequence conflicti | 147 | F → S in ADG45012 (Ref. 4) Curated | 1 | |
Sequence conflicti | 188 | M → V in ADG45015 (Ref. 4) Curated | 1 | |
Sequence conflicti | 207 | F → L in AAB97725 (PubMed:9675259).Curated | 1 | |
Sequence conflicti | 232 | T → S in ADG45015 (Ref. 4) Curated | 1 | |
Sequence conflicti | 267 | E → V in CAG46634 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022051 | 4 | R → Q1 PublicationCorresponds to variant dbSNP:rs2290228Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045939 | 1 – 151 | Missing in isoform 15. 1 PublicationAdd BLAST | 151 | |
Alternative sequenceiVSP_043570 | 1 | M → MKETDLIIM in isoform 3, isoform 4 and isoform 14. 2 Publications | 1 | |
Alternative sequenceiVSP_045940 | 75 – 315 | Missing in isoform 12. 1 PublicationAdd BLAST | 241 | |
Alternative sequenceiVSP_007317 | 75 – 137 | KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8. 3 PublicationsAdd BLAST | 63 | |
Alternative sequenceiVSP_045941 | 94 – 254 | Missing in isoform 9. 1 PublicationAdd BLAST | 161 | |
Alternative sequenceiVSP_045942 | 139 | D → E in isoform 13 and isoform 14. 1 Publication | 1 | |
Alternative sequenceiVSP_045943 | 140 – 315 | Missing in isoform 13 and isoform 14. 1 PublicationAdd BLAST | 176 | |
Alternative sequenceiVSP_045944 | 154 – 161 | VRDERRFK → GILMSRNG in isoform 7. 1 Publication | 8 | |
Alternative sequenceiVSP_045945 | 162 – 315 | Missing in isoform 7. 1 PublicationAdd BLAST | 154 | |
Alternative sequenceiVSP_045946 | 164 – 249 | Missing in isoform 5. 1 PublicationAdd BLAST | 86 | |
Alternative sequenceiVSP_045947 | 165 – 170 | KDGDLI → RARAVC in isoform 11. 1 Publication | 6 | |
Alternative sequenceiVSP_045948 | 171 – 315 | Missing in isoform 11. 1 PublicationAdd BLAST | 145 | |
Alternative sequenceiVSP_045949 | 172 – 285 | Missing in isoform 8. 1 PublicationAdd BLAST | 114 | |
Alternative sequenceiVSP_045950 | 216 – 315 | DMYSH…RHDEF → WQAYQGGDR in isoform 10. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_045951 | 226 – 275 | Missing in isoform 6. 1 PublicationAdd BLAST | 50 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000249364; ENSP00000249364; ENSG00000128595 ENST00000449187; ENSP00000408838; ENSG00000128595 [O43852-2] ENST00000479257; ENSP00000420381; ENSG00000128595 [O43852-3] ENST00000535011; ENSP00000442110; ENSG00000128595 [O43852-10] ENST00000542996; ENSP00000438248; ENSG00000128595 [O43852-4] |
GeneIDi | 813 |
KEGGi | hsa:813 |
MANE-Selecti | ENST00000249364.9; ENSP00000249364.4; NM_001219.5; NP_001210.1 |
UCSCi | uc003vnr.4, human [O43852-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SASBDBi | O43852 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107263, 276 interactors |
IntActi | O43852, 87 interactors |
MINTi | O43852 |
STRINGi | 9606.ENSP00000438248 |
PTM databases
GlyConnecti | 1062, 43 N-Linked glycans (1 site) |
GlyGeni | O43852, 3 sites, 45 N-linked glycans (1 site), 2 O-linked glycans (2 sites) |
iPTMneti | O43852 |
MetOSitei | O43852 |
PhosphoSitePlusi | O43852 |
SwissPalmi | O43852 |
Genetic variation databases
BioMutai | CALU |
2D gel databases
DOSAC-COBS-2DPAGEi | O43852 |
Proteomic databases
EPDi | O43852 |
jPOSTi | O43852 |
MassIVEi | O43852 |
MaxQBi | O43852 |
PaxDbi | O43852 |
PeptideAtlasi | O43852 |
PRIDEi | O43852 |
ProteomicsDBi | 25733 27707 49203 [O43852-1] 49204 [O43852-2] 49205 [O43852-3] 49206 [O43852-4] |
TopDownProteomicsi | O43852-1 [O43852-1] O43852-2 [O43852-2] O43852-3 [O43852-3] O43852-4 [O43852-4] O43852-5 [O43852-5] O43852-6 [O43852-6] O43852-8 [O43852-8] O43852-9 [O43852-9] |
Protocols and materials databases
Antibodypediai | 1219, 270 antibodies from 33 providers |
DNASUi | 813 |
Genome annotation databases
Ensembli | ENST00000249364; ENSP00000249364; ENSG00000128595 ENST00000449187; ENSP00000408838; ENSG00000128595 [O43852-2] ENST00000479257; ENSP00000420381; ENSG00000128595 [O43852-3] ENST00000535011; ENSP00000442110; ENSG00000128595 [O43852-10] ENST00000542996; ENSP00000438248; ENSG00000128595 [O43852-4] |
GeneIDi | 813 |
KEGGi | hsa:813 |
MANE-Selecti | ENST00000249364.9; ENSP00000249364.4; NM_001219.5; NP_001210.1 |
UCSCi | uc003vnr.4, human [O43852-1] |
Organism-specific databases
CTDi | 813 |
DisGeNETi | 813 |
GeneCardsi | CALU |
HGNCi | HGNC:1458, CALU |
HPAi | ENSG00000128595, Low tissue specificity |
MIMi | 603420, gene |
neXtProti | NX_O43852 |
OpenTargetsi | ENSG00000128595 |
PharmGKBi | PA26047 |
VEuPathDBi | HostDB:ENSG00000128595 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4223, Eukaryota |
GeneTreei | ENSGT01010000222360 |
HOGENOMi | CLU_044718_0_1_1 |
InParanoidi | O43852 |
OrthoDBi | 909079at2759 |
PhylomeDBi | O43852 |
TreeFami | TF314849 |
Enzyme and pathway databases
PathwayCommonsi | O43852 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | O43852 |
SIGNORi | O43852 |
Miscellaneous databases
BioGRID-ORCSi | 813, 7 hits in 1045 CRISPR screens |
ChiTaRSi | CALU, human |
GeneWikii | CALU_(gene) |
GenomeRNAii | 813 |
Pharosi | O43852, Tbio |
PROi | PR:O43852 |
RNActi | O43852, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128595, Expressed in stromal cell of endometrium and 249 other tissues |
ExpressionAtlasi | O43852, baseline and differential |
Genevisiblei | O43852, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027239, Calumenin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR10827:SF76, PTHR10827:SF76, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 2 hits PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CALU_HUMAN | |
Accessioni | O43852Primary (citable) accession number: O43852 Secondary accession number(s): B3KPG9 Q9NR43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 204 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families