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Protein

Calumenin

Gene

CALU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi81 – 921PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi117 – 1282PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi164 – 1753; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi201 – 2124PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi242 – 2535PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi278 – 2896PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Alternative name(s):
Crocalbin
IEF SSP 9302
Gene namesi
Name:CALU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128595.16
HGNCiHGNC:1458 CALU
MIMi603420 gene
neXtProtiNX_O43852

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi813
OpenTargetsiENSG00000128595
PharmGKBiPA26047

Polymorphism and mutation databases

BioMutaiCALU

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000000415320 – 315CalumeninAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei65PhosphothreonineCombined sources1
Modified residuei69Phosphoserine; by FAM20C1 Publication1
Glycosylationi131N-linked (GlcNAc...) (complex) asparagine2 Publications1
Modified residuei165N6-acetyllysineBy similarity1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO43852
PaxDbiO43852
PeptideAtlasiO43852
PRIDEiO43852
ProteomicsDBi49203
49204 [O43852-2]
49205 [O43852-3]
49206 [O43852-4]
TopDownProteomicsiO43852-1 [O43852-1]
O43852-2 [O43852-2]
O43852-3 [O43852-3]
O43852-4 [O43852-4]
O43852-5 [O43852-5]
O43852-6 [O43852-6]
O43852-8 [O43852-8]
O43852-9 [O43852-9]

2D gel databases

DOSAC-COBS-2DPAGEiO43852

PTM databases

iPTMnetiO43852
PhosphoSitePlusiO43852
SwissPalmiO43852

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Gene expression databases

BgeeiENSG00000128595
CleanExiHS_CALU
ExpressionAtlasiO43852 baseline and differential
GenevisibleiO43852 HS

Organism-specific databases

HPAiHPA006018

Interactioni

Subunit structurei

Interacts with GGCX.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107263, 139 interactors
IntActiO43852, 55 interactors
MINTiO43852
STRINGi9606.ENSP00000420381

Structurei

3D structure databases

ProteinModelPortaliO43852
SMRiO43852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 103EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini104 – 139EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini188 – 223EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini229 – 264EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini265 – 300EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 315Prevents secretion from ERBy similarity4

Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223 Eukaryota
ENOG410XRVE LUCA
GeneTreeiENSGT00550000074546
HOGENOMiHOG000230934
HOVERGENiHBG002834
InParanoidiO43852
OMAiNVERQWQ
OrthoDBiEOG091G0GUL
PhylomeDBiO43852
TreeFamiTF314849

Family and domain databases

InterProiView protein in InterPro
IPR027239 Calumenin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR10827:SF70 PTHR10827:SF70, 1 hit
PfamiView protein in Pfam
PF13202 EF-hand_5, 2 hits
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 6 hits

Sequences (15)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43852-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD
60 70 80 90 100
AFLGAEEAKT FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA
110 120 130 140 150
QKRWIYEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK
160 170 180 190 200
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI
210 220 230 240 250
DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF RDKNRDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Length:315
Mass (Da):37,107
Last modified:July 15, 1999 - v2
Checksum:i25BAE5A99B527375
GO
Isoform 2 (identifier: O43852-2) [UniParc]FASTAAdd to basket
Also known as: Crocalbin

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Show »
Length:315
Mass (Da):37,135
Checksum:iE1BF415B25076676
GO
Isoform 3 (identifier: O43852-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM

Show »
Length:323
Mass (Da):38,051
Checksum:i0357815A65B4C364
GO
Isoform 4 (identifier: O43852-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Show »
Length:323
Mass (Da):38,079
Checksum:iC75225A8DBE1D667
GO
Isoform 5 (identifier: O43852-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-249: Missing.

Show »
Length:229
Mass (Da):26,892
Checksum:iB73499A59B44F6D0
GO
Isoform 6 (identifier: O43852-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-275: Missing.

Show »
Length:265
Mass (Da):30,957
Checksum:i853B18C78BFD2FD5
GO
Isoform 7 (identifier: O43852-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     154-161: VRDERRFK → GILMSRNG
     162-315: Missing.

Show »
Length:161
Mass (Da):18,789
Checksum:i2F30CCD0362501B9
GO
Isoform 8 (identifier: O43852-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     172-285: Missing.

Show »
Length:201
Mass (Da):23,519
Checksum:i031A48109B3A5721
GO
Isoform 9 (identifier: O43852-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-254: Missing.

Show »
Length:154
Mass (Da):17,639
Checksum:iC01A8709FEEEE48F
GO
Isoform 10 (identifier: O43852-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR

Show »
Length:224
Mass (Da):26,326
Checksum:iA58B5C4DF48D5C56
GO
Isoform 11 (identifier: O43852-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-170: KDGDLI → RARAVC
     171-315: Missing.

Show »
Length:170
Mass (Da):19,993
Checksum:iDE2FFE0A2E51C11B
GO
Isoform 12 (identifier: O43852-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-315: Missing.

Show »
Length:74
Mass (Da):8,511
Checksum:i24C00B317B5508DE
GO
Isoform 13 (identifier: O43852-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: D → E
     140-315: Missing.

Show »
Length:139
Mass (Da):16,291
Checksum:iDC485712A52F6454
GO
Isoform 14 (identifier: O43852-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     139-139: D → E
     140-315: Missing.

Show »
Length:147
Mass (Da):17,235
Checksum:i895C953C9569567E
GO
Isoform 15 (identifier: O43852-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:164
Mass (Da):19,455
Checksum:iE53F4259F8265B8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48D → G in ADG45013 (Ref. 4) Curated1
Sequence conflicti84K → R in ADG45007 (Ref. 4) Curated1
Sequence conflicti90V → A in ADG45010 (Ref. 4) Curated1
Sequence conflicti117D → G in ADG45007 (Ref. 4) Curated1
Sequence conflicti118L → H in ADG45011 (Ref. 4) Curated1
Sequence conflicti147F → S in ADG45012 (Ref. 4) Curated1
Sequence conflicti188M → V in ADG45015 (Ref. 4) Curated1
Sequence conflicti207F → L in AAB97725 (PubMed:9675259).Curated1
Sequence conflicti232T → S in ADG45015 (Ref. 4) Curated1
Sequence conflicti267E → V in CAG46634 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0220514R → Q1 PublicationCorresponds to variant dbSNP:rs2290228Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459391 – 151Missing in isoform 15. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_0435701M → MKETDLIIM in isoform 3, isoform 4 and isoform 14. 2 Publications1
Alternative sequenceiVSP_04594075 – 315Missing in isoform 12. 1 PublicationAdd BLAST241
Alternative sequenceiVSP_00731775 – 137KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8. 3 PublicationsAdd BLAST63
Alternative sequenceiVSP_04594194 – 254Missing in isoform 9. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_045942139D → E in isoform 13 and isoform 14. 1 Publication1
Alternative sequenceiVSP_045943140 – 315Missing in isoform 13 and isoform 14. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_045944154 – 161VRDERRFK → GILMSRNG in isoform 7. 1 Publication8
Alternative sequenceiVSP_045945162 – 315Missing in isoform 7. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_045946164 – 249Missing in isoform 5. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_045947165 – 170KDGDLI → RARAVC in isoform 11. 1 Publication6
Alternative sequenceiVSP_045948171 – 315Missing in isoform 11. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_045949172 – 285Missing in isoform 8. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_045950216 – 315DMYSH…RHDEF → WQAYQGGDR in isoform 10. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_045951226 – 275Missing in isoform 6. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67280 mRNA Translation: AAB97725.1
AF013759 mRNA Translation: AAC17216.1
AF345637 mRNA Translation: AAK72908.1
HM002604 mRNA Translation: ADG45004.1
HM002605 mRNA Translation: ADG45005.1
HM002606 mRNA Translation: ADG45006.1
HM002607 mRNA Translation: ADG45007.1
HM002608 mRNA Translation: ADG45008.1
HM002609 mRNA Translation: ADG45009.1
HM002610 mRNA Translation: ADG45010.1
HM002611 mRNA Translation: ADG45011.1
HM002612 mRNA Translation: ADG45012.1
HM002613 mRNA Translation: ADG45013.1
HM002614 mRNA Translation: ADG45014.1
HM002615 mRNA Translation: ADG45015.1
HM002616 mRNA Translation: ADG45016.1
AK056338 mRNA Translation: BAG51681.1
CR541835 mRNA Translation: CAG46634.1
AC024952 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83679.1
BC013383 mRNA Translation: AAH13383.1
AF257659 mRNA Translation: AAF76141.1
CCDSiCCDS47703.1 [O43852-2]
CCDS56506.1 [O43852-3]
CCDS56507.1 [O43852-4]
CCDS56508.1 [O43852-10]
CCDS5805.1 [O43852-1]
RefSeqiNP_001124146.1, NM_001130674.2 [O43852-2]
NP_001186600.1, NM_001199671.1 [O43852-3]
NP_001186601.1, NM_001199672.1 [O43852-4]
NP_001186602.1, NM_001199673.1 [O43852-10]
NP_001210.1, NM_001219.4 [O43852-1]
XP_016868148.1, XM_017012659.1 [O43852-15]
UniGeneiHs.743262
Hs.7753

Genome annotation databases

EnsembliENST00000249364; ENSP00000249364; ENSG00000128595 [O43852-1]
ENST00000449187; ENSP00000408838; ENSG00000128595 [O43852-2]
ENST00000479257; ENSP00000420381; ENSG00000128595 [O43852-3]
ENST00000535011; ENSP00000442110; ENSG00000128595 [O43852-10]
ENST00000542996; ENSP00000438248; ENSG00000128595 [O43852-4]
GeneIDi813
KEGGihsa:813
UCSCiuc003vnr.4 human [O43852-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCALU_HUMAN
AccessioniPrimary (citable) accession number: O43852
Secondary accession number(s): B3KPG9
, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52, D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, D6QS58, D6QS59, F5H1Q9, F5H879, O60456, Q6FHB9, Q96RL3, Q9NR43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: July 18, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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