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Protein

Angiopoietin-related protein 7

Gene

ANGPTL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • response to oxidative stress Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 7
Alternative name(s):
Angiopoietin-like factor
Angiopoietin-like protein 7
Cornea-derived transcript 6 protein
Gene namesi
Name:ANGPTL7
Synonyms:CDT6
ORF Names:UNQ313/PRO356
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171819.4
HGNCiHGNC:24078 ANGPTL7
neXtProtiNX_O43827

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10218
OpenTargetsiENSG00000171819
PharmGKBiPA134959516

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000913127 – 346Angiopoietin-related protein 7Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 162PROSITE-ProRule annotation
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi285 ↔ 298PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43827
PeptideAtlasiO43827
PRIDEiO43827
ProteomicsDBi49194

PTM databases

iPTMnetiO43827
PhosphoSitePlusiO43827

Expressioni

Tissue specificityi

Highly and specifically expressed in the cornea where is confined to the stromal layer.1 Publication

Gene expression databases

BgeeiENSG00000171819 Expressed in 103 organ(s), highest expression level in tibial nerve
CleanExiHS_ANGPTL7
GenevisibleiO43827 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356093EBI-12698369,EBI-77797

Protein-protein interaction databases

BioGridi115513, 17 interactors
IntActiO43827, 1 interactor
STRINGi9606.ENSP00000366015

Structurei

3D structure databases

ProteinModelPortaliO43827
SMRiO43827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 343Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST222

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 119Sequence analysisAdd BLAST81

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO43827
OMAiDKCVDDC
OrthoDBiEOG091G03M1
PhylomeDBiO43827
TreeFamiTF329953

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43827-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKKPLSAVT WLCIFIVAFV SHPAWLQKLS KHKTPAQPQL KAANCCEEVK
60 70 80 90 100
ELKAQVANLS SLLSELNKKQ ERDWVSVVMQ VMELESNSKR MESRLTDAES
110 120 130 140 150
KYSEMNNQID IMQLQAAQTV TQTSADAIYD CSSLYQKNYR ISGVYKLPPD
160 170 180 190 200
DFLGSPELEV FCDMETSGGG WTIIQRRKSG LVSFYRDWKQ YKQGFGSIRG
210 220 230 240 250
DFWLGNEHIH RLSRQPTRLR VEMEDWEGNL RYAEYSHFVL GNELNSYRLF
260 270 280 290 300
LGNYTGNVGN DALQYHNNTA FSTKDKDNDN CLDKCAQLRK GGYWYNCCTD
310 320 330 340
SNLNGVYYRL GEHNKHLDGI TWYGWHGSTY SLKRVEMKIR PEDFKP
Length:346
Mass (Da):40,018
Last modified:June 1, 1998 - v1
Checksum:iAEC0A601CC498B43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02507551E → D1 PublicationCorresponds to variant dbSNP:rs28990992Ensembl.1
Natural variantiVAR_025076140R → H1 PublicationCorresponds to variant dbSNP:rs28991002Ensembl.1
Natural variantiVAR_025077175Q → H1 PublicationCorresponds to variant dbSNP:rs28991009Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16132 mRNA Translation: CAA76078.1
AJ300188 Genomic DNA Translation: CAC15571.1
AY358301 mRNA Translation: AAQ88668.1
BT009802 mRNA Translation: AAP88804.1
AK313716 mRNA Translation: BAG36459.1
DQ012507 Genomic DNA Translation: AAY22173.1
AB593026 mRNA Translation: BAJ83980.1
AB593027 mRNA Translation: BAJ83981.1
AL049653 Genomic DNA No translation available.
AL391561 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71685.1
BC001881 mRNA Translation: AAH01881.1
CCDSiCCDS128.1
RefSeqiNP_066969.1, NM_021146.3
UniGeneiHs.146559

Genome annotation databases

EnsembliENST00000376819; ENSP00000366015; ENSG00000171819
GeneIDi10218
KEGGihsa:10218
UCSCiuc001ase.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16132 mRNA Translation: CAA76078.1
AJ300188 Genomic DNA Translation: CAC15571.1
AY358301 mRNA Translation: AAQ88668.1
BT009802 mRNA Translation: AAP88804.1
AK313716 mRNA Translation: BAG36459.1
DQ012507 Genomic DNA Translation: AAY22173.1
AB593026 mRNA Translation: BAJ83980.1
AB593027 mRNA Translation: BAJ83981.1
AL049653 Genomic DNA No translation available.
AL391561 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71685.1
BC001881 mRNA Translation: AAH01881.1
CCDSiCCDS128.1
RefSeqiNP_066969.1, NM_021146.3
UniGeneiHs.146559

3D structure databases

ProteinModelPortaliO43827
SMRiO43827
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115513, 17 interactors
IntActiO43827, 1 interactor
STRINGi9606.ENSP00000366015

PTM databases

iPTMnetiO43827
PhosphoSitePlusiO43827

Proteomic databases

PaxDbiO43827
PeptideAtlasiO43827
PRIDEiO43827
ProteomicsDBi49194

Protocols and materials databases

DNASUi10218
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376819; ENSP00000366015; ENSG00000171819
GeneIDi10218
KEGGihsa:10218
UCSCiuc001ase.5 human

Organism-specific databases

CTDi10218
DisGeNETi10218
EuPathDBiHostDB:ENSG00000171819.4
GeneCardsiANGPTL7
HGNCiHGNC:24078 ANGPTL7
neXtProtiNX_O43827
OpenTargetsiENSG00000171819
PharmGKBiPA134959516
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO43827
OMAiDKCVDDC
OrthoDBiEOG091G03M1
PhylomeDBiO43827
TreeFamiTF329953

Miscellaneous databases

GeneWikiiANGPTL7
GenomeRNAii10218
PROiPR:O43827

Gene expression databases

BgeeiENSG00000171819 Expressed in 103 organ(s), highest expression level in tibial nerve
CleanExiHS_ANGPTL7
GenevisibleiO43827 HS

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANGL7_HUMAN
AccessioniPrimary (citable) accession number: O43827
Secondary accession number(s): B2R9B2, F1T0A6, Q4ZGK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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