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Protein

Glucose-6-phosphate exchanger SLC37A4

Gene

SLC37A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.2 Publications

Activity regulationi

Inhibited by vanadate and chlorogenic acid.1 Publication

GO - Molecular functioni

  • glucose 6-phosphate:inorganic phosphate antiporter activity Source: UniProtKB
  • glucose-6-phosphate transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAntiport, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-3229133 Glycogen storage disease type Ib (SLC37A4)
R-HSA-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.1.4.5 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A42 Publications
Alternative name(s):
Glucose-5-phosphate transporter
Glucose-6-phosphate translocase1 Publication
Solute carrier family 37 member 4Imported
Transformation-related gene 19 proteinImported
Short name:
TRG-19Imported
Gene namesi
Name:SLC37A4Imported
Synonyms:G6PT, G6PT1
ORF Names:PRO0685, TRG19Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4061 SLC37A4
MIMi602671 gene
neXtProtiNX_O43826

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Glycogen storage disease 1B (GSD1B)21 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Glycogen storage disease type 1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease.
See also OMIM:232220
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02558120G → D in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302881EnsemblClinVar.1
Natural variantiVAR_02558224Y → H in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302887EnsemblClinVar.1
Natural variantiVAR_02558327N → K in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302889EnsemblClinVar.1
Natural variantiVAR_02558428R → C in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302882EnsemblClinVar.1
Natural variantiVAR_01684028R → H in GSD1B; inactive glucose-6-phosphate transport. 2 PublicationsCorresponds to variant dbSNP:rs121908978EnsemblClinVar.1
Natural variantiVAR_06639450G → E in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302877EnsemblClinVar.1
Natural variantiVAR_02558550G → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302894EnsemblClinVar.1
Natural variantiVAR_02558654S → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302898EnsemblClinVar.1
Natural variantiVAR_02558755S → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302884EnsemblClinVar.1
Natural variantiVAR_02558868G → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302885EnsemblClinVar.1
Natural variantiVAR_02558985L → P in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302899EnsemblClinVar.1
Natural variantiVAR_02559088G → D in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302886EnsemblClinVar.1
Natural variantiVAR_007850118W → R in GSD1B. 4 PublicationsCorresponds to variant dbSNP:rs80356489EnsemblClinVar.1
Natural variantiVAR_066395148A → V in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302879EnsemblClinVar.1
Natural variantiVAR_003184149G → E in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302892EnsemblClinVar.1
Natural variantiVAR_025592150G → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302883EnsemblClinVar.1
Natural variantiVAR_025593153P → L in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302890EnsemblClinVar.1
Natural variantiVAR_025594176C → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302895EnsemblClinVar.1
Natural variantiVAR_025595183C → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302893EnsemblClinVar.1
Natural variantiVAR_032113191P → L in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302888EnsemblClinVar.1
Natural variantiVAR_025597229L → P in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302902EnsemblClinVar.1
Natural variantiVAR_012356235Missing in GSD1B. 1 Publication1
Natural variantiVAR_066396246W → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302878EnsemblClinVar.1
Natural variantiVAR_025598278I → N in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302900EnsemblClinVar.1
Natural variantiVAR_066397300R → C in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302880EnsemblClinVar.1
Natural variantiVAR_025599300R → H in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302903EnsemblClinVar.1
Natural variantiVAR_025600301H → P in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302891EnsemblClinVar.1
Natural variantiVAR_003185339G → C in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs80356490EnsemblClinVar.1
Natural variantiVAR_025601339G → D in GSD1B. 2 PublicationsCorresponds to variant dbSNP:rs121908980EnsemblClinVar.1
Natural variantiVAR_025602367A → T in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs80356492EnsemblClinVar.1
Natural variantiVAR_025603373A → D in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302901EnsemblClinVar.1
Glycogen storage disease 1C (GSD1C)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia.
See also OMIM:232240
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025591133Q → P in GSD1C. 1 PublicationCorresponds to variant dbSNP:rs193302896EnsemblClinVar.1
Natural variantiVAR_025604376G → S in GSD1C. 1 PublicationCorresponds to variant dbSNP:rs193302897EnsemblClinVar.1
Glycogen storage disease 1D (GSD1D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia.
See also OMIM:232240

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNETi2542
GeneReviewsiSLC37A4
MalaCardsiSLC37A4
MIMi232220 phenotype
232240 phenotype
Orphaneti79259 Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
PharmGKBiPA28472

Chemistry databases

ChEMBLiCHEMBL3217398

Polymorphism and mutation databases

BioMutaiSLC37A4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998911 – 429Glucose-6-phosphate exchanger SLC37A4Add BLAST429

Proteomic databases

EPDiO43826
MaxQBiO43826
PeptideAtlasiO43826
PRIDEiO43826
ProteomicsDBi49192
49193 [O43826-2]

PTM databases

iPTMnetiO43826
PhosphoSitePlusiO43826

Expressioni

Tissue specificityi

Mostly expressed in liver and kidney.

Gene expression databases

CleanExiHS_SLC37A4

Organism-specific databases

HPAiHPA038939
HPA038940

Interactioni

Protein-protein interaction databases

BioGridi108817, 2 interactors
IntActiO43826, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliO43826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000274730
HOVERGENiHBG051682
InParanoidiO43826
KOiK08171
OrthoDBiEOG091G06B9
PhylomeDBiO43826

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR021159 Sugar-P_transporter_CS
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS00942 GLPT, 1 hit
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43826-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG
60 70 80 90 100
FITSSQSAAY AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV
110 120 130 140 150
PVFAALWFLN GLAQGLGWPP CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG
160 170 180 190 200
LGPILATILA QSYSWRSTLA LSGALCVVVS FLCLLLIHNE PADVGLRNLD
210 220 230 240 250
PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK TCCTDWGQFF
260 270 280 290 300
LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR
310 320 330 340 350
HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG
360 370 380 390 400
VIANESAPPN LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA
410 420
EVICAASTAA FFLLRNIRTK MGRVSKKAE
Length:429
Mass (Da):46,360
Last modified:June 1, 1998 - v1
Checksum:iC0399332FE72694B
GO
Isoform 2 (identifier: O43826-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → KDVAFWTLALHPLAELTGFTEHE

Show »
Length:451
Mass (Da):48,840
Checksum:iA5696ADCDC67D90A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQS2U3KQS2_HUMAN
Glucose-6-phosphate exchanger SLC37...
SLC37A4
451Annotation score:
U3KQL4U3KQL4_HUMAN
Glucose-6-phosphate exchanger SLC37...
SLC37A4
356Annotation score:
U3KPU7U3KPU7_HUMAN
Glucose-6-phosphate exchanger SLC37...
SLC37A4
429Annotation score:

Sequence cautioni

The sequence AAF16691 differs from that shown. Reason: Frameshift at position 128.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109L → F in AAD19898 (PubMed:10026167).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02558120G → D in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302881EnsemblClinVar.1
Natural variantiVAR_02558224Y → H in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302887EnsemblClinVar.1
Natural variantiVAR_02558327N → K in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302889EnsemblClinVar.1
Natural variantiVAR_02558428R → C in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302882EnsemblClinVar.1
Natural variantiVAR_01684028R → H in GSD1B; inactive glucose-6-phosphate transport. 2 PublicationsCorresponds to variant dbSNP:rs121908978EnsemblClinVar.1
Natural variantiVAR_06639450G → E in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302877EnsemblClinVar.1
Natural variantiVAR_02558550G → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302894EnsemblClinVar.1
Natural variantiVAR_02558654S → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302898EnsemblClinVar.1
Natural variantiVAR_02558755S → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302884EnsemblClinVar.1
Natural variantiVAR_02558868G → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302885EnsemblClinVar.1
Natural variantiVAR_02558985L → P in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302899EnsemblClinVar.1
Natural variantiVAR_02559088G → D in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302886EnsemblClinVar.1
Natural variantiVAR_007850118W → R in GSD1B. 4 PublicationsCorresponds to variant dbSNP:rs80356489EnsemblClinVar.1
Natural variantiVAR_025591133Q → P in GSD1C. 1 PublicationCorresponds to variant dbSNP:rs193302896EnsemblClinVar.1
Natural variantiVAR_066395148A → V in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302879EnsemblClinVar.1
Natural variantiVAR_003184149G → E in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302892EnsemblClinVar.1
Natural variantiVAR_025592150G → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302883EnsemblClinVar.1
Natural variantiVAR_025593153P → L in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302890EnsemblClinVar.1
Natural variantiVAR_025594176C → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302895EnsemblClinVar.1
Natural variantiVAR_025595183C → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302893EnsemblClinVar.1
Natural variantiVAR_032113191P → L in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302888EnsemblClinVar.1
Natural variantiVAR_025596198N → I1 PublicationCorresponds to variant dbSNP:rs34203644EnsemblClinVar.1
Natural variantiVAR_025597229L → P in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302902EnsemblClinVar.1
Natural variantiVAR_012356235Missing in GSD1B. 1 Publication1
Natural variantiVAR_066396246W → R in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302878EnsemblClinVar.1
Natural variantiVAR_025598278I → N in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302900EnsemblClinVar.1
Natural variantiVAR_066397300R → C in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302880EnsemblClinVar.1
Natural variantiVAR_025599300R → H in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302903EnsemblClinVar.1
Natural variantiVAR_025600301H → P in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302891EnsemblClinVar.1
Natural variantiVAR_003185339G → C in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs80356490EnsemblClinVar.1
Natural variantiVAR_025601339G → D in GSD1B. 2 PublicationsCorresponds to variant dbSNP:rs121908980EnsemblClinVar.1
Natural variantiVAR_025602367A → T in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs80356492EnsemblClinVar.1
Natural variantiVAR_025603373A → D in GSD1B. 1 PublicationCorresponds to variant dbSNP:rs193302901EnsemblClinVar.1
Natural variantiVAR_025604376G → S in GSD1C. 1 PublicationCorresponds to variant dbSNP:rs193302897EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006171328K → KDVAFWTLALHPLAELTGFT EHE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15409 mRNA Translation: CAA75608.1
AF078163 Genomic DNA Translation: AAC72916.1
AF097831 Genomic DNA Translation: AAD19898.1
AF111852 mRNA Translation: AAF16691.1 Frameshift.
AF110819 mRNA Translation: AAF37735.1
AF110820 mRNA Translation: AAF37736.1
Y17864 Genomic DNA Translation: CAA76898.1
AF116864, AF116862, AF116863 Genomic DNA Translation: AAD13111.1
AY423732 mRNA Translation: AAS00495.1
CH471065 Genomic DNA Translation: EAW67432.1
BC002400 mRNA Translation: AAH02400.1
BC003589 mRNA Translation: AAH03589.1
BC014663 mRNA Translation: AAH14663.1
BC015650 mRNA Translation: AAH15650.1
BC064563 mRNA Translation: AAH64563.1
RefSeqiNP_001157749.1, NM_001164277.1 [O43826-1]
NP_001157750.1, NM_001164278.1 [O43826-2]
NP_001157751.1, NM_001164279.1
NP_001157752.1, NM_001164280.1 [O43826-1]
NP_001458.1, NM_001467.5 [O43826-1]
UniGeneiHs.719203

Genome annotation databases

EnsembliENST00000631372; ENSP00000486168; ENSG00000281500 [O43826-2]
ENST00000642844; ENSP00000493469; ENSG00000281500 [O43826-1]
ENST00000644666; ENSP00000494243; ENSG00000281500 [O43826-2]
ENST00000645735; ENSP00000495653; ENSG00000281500 [O43826-1]
GeneIDi2542
KEGGihsa:2542

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Mendelian genes solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15409 mRNA Translation: CAA75608.1
AF078163 Genomic DNA Translation: AAC72916.1
AF097831 Genomic DNA Translation: AAD19898.1
AF111852 mRNA Translation: AAF16691.1 Frameshift.
AF110819 mRNA Translation: AAF37735.1
AF110820 mRNA Translation: AAF37736.1
Y17864 Genomic DNA Translation: CAA76898.1
AF116864, AF116862, AF116863 Genomic DNA Translation: AAD13111.1
AY423732 mRNA Translation: AAS00495.1
CH471065 Genomic DNA Translation: EAW67432.1
BC002400 mRNA Translation: AAH02400.1
BC003589 mRNA Translation: AAH03589.1
BC014663 mRNA Translation: AAH14663.1
BC015650 mRNA Translation: AAH15650.1
BC064563 mRNA Translation: AAH64563.1
RefSeqiNP_001157749.1, NM_001164277.1 [O43826-1]
NP_001157750.1, NM_001164278.1 [O43826-2]
NP_001157751.1, NM_001164279.1
NP_001157752.1, NM_001164280.1 [O43826-1]
NP_001458.1, NM_001467.5 [O43826-1]
UniGeneiHs.719203

3D structure databases

ProteinModelPortaliO43826
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108817, 2 interactors
IntActiO43826, 3 interactors

Chemistry databases

ChEMBLiCHEMBL3217398

Protein family/group databases

TCDBi2.A.1.4.5 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO43826
PhosphoSitePlusiO43826

Polymorphism and mutation databases

BioMutaiSLC37A4

Proteomic databases

EPDiO43826
MaxQBiO43826
PeptideAtlasiO43826
PRIDEiO43826
ProteomicsDBi49192
49193 [O43826-2]

Protocols and materials databases

DNASUi2542
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000631372; ENSP00000486168; ENSG00000281500 [O43826-2]
ENST00000642844; ENSP00000493469; ENSG00000281500 [O43826-1]
ENST00000644666; ENSP00000494243; ENSG00000281500 [O43826-2]
ENST00000645735; ENSP00000495653; ENSG00000281500 [O43826-1]
GeneIDi2542
KEGGihsa:2542

Organism-specific databases

CTDi2542
DisGeNETi2542
GeneCardsiSLC37A4
GeneReviewsiSLC37A4
HGNCiHGNC:4061 SLC37A4
HPAiHPA038939
HPA038940
MalaCardsiSLC37A4
MIMi232220 phenotype
232240 phenotype
602671 gene
neXtProtiNX_O43826
Orphaneti79259 Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
PharmGKBiPA28472
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000274730
HOVERGENiHBG051682
InParanoidiO43826
KOiK08171
OrthoDBiEOG091G06B9
PhylomeDBiO43826

Enzyme and pathway databases

ReactomeiR-HSA-3229133 Glycogen storage disease type Ib (SLC37A4)
R-HSA-70263 Gluconeogenesis

Miscellaneous databases

GeneWikiiSLC37A4
GenomeRNAii2542
PROiPR:O43826
SOURCEiSearch...

Gene expression databases

CleanExiHS_SLC37A4

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR021159 Sugar-P_transporter_CS
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS00942 GLPT, 1 hit
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG6PT1_HUMAN
AccessioniPrimary (citable) accession number: O43826
Secondary accession number(s): O96016
, Q5J7V4, Q9UI19, Q9UNS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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