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Protein

Beta-1,3-galactosyltransferase 2

Gene

B3GALT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.2 Publications

Catalytic activityi

UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R.2 Publications

Cofactori

Mn2+By similarity

Kineticsi

  1. KM=90 µM for UDP-alpha-D-galactose1 Publication

    Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    GO - Molecular functioni

    GO - Biological processi

    • galactosylceramide biosynthetic process Source: BHF-UCL
    • oligosaccharide biosynthetic process Source: Ensembl
    • protein glycosylation Source: ProtInc

    Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    LigandManganese

    Enzyme and pathway databases

    BRENDAi2.4.1.62 2681
    UniPathwayiUPA00378

    Protein family/group databases

    CAZyiGT31 Glycosyltransferase Family 31

    Chemistry databases

    SwissLipidsiSLP:000000773

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1,3-galactosyltransferase 2 (EC:2.4.1.862 Publications)
    Short name:
    Beta-1,3-GalTase 2
    Short name:
    Beta3Gal-T2
    Short name:
    Beta3GalT2
    Alternative name(s):
    UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
    Gene namesi
    Name:B3GALT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000162630.5
    HGNCiHGNC:917 B3GALT2
    MIMi603018 gene
    neXtProtiNX_O43825

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
    Transmembranei25 – 45Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini46 – 422LumenalSequence analysisAdd BLAST377

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    OpenTargetsiENSG00000162630
    PharmGKBiPA25210

    Polymorphism and mutation databases

    BioMutaiB3GALT2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002191501 – 422Beta-1,3-galactosyltransferase 2Add BLAST422

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO43825
    PRIDEiO43825
    ProteomicsDBi49191

    PTM databases

    iPTMnetiO43825
    PhosphoSitePlusiO43825

    Expressioni

    Tissue specificityi

    Detected in heart and brain.2 Publications

    Gene expression databases

    BgeeiENSG00000162630
    CleanExiHS_B3GALT2
    GenevisibleiO43825 HS

    Interactioni

    Protein-protein interaction databases

    BioGridi114250, 11 interactors
    IntActiO43825, 1 interactor
    STRINGi9606.ENSP00000356404

    Structurei

    3D structure databases

    ProteinModelPortaliO43825
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG2287 Eukaryota
    ENOG410ZZ1B LUCA
    GeneTreeiENSGT00760000118879
    HOGENOMiHOG000059604
    HOVERGENiHBG101354
    InParanoidiO43825
    KOiK07820
    OMAiYTIRGFR
    OrthoDBiEOG091G0AXM
    PhylomeDBiO43825
    TreeFamiTF318639

    Family and domain databases

    InterProiView protein in InterPro
    IPR002659 Glyco_trans_31
    PANTHERiPTHR11214 PTHR11214, 1 hit
    PfamiView protein in Pfam
    PF01762 Galactosyl_T, 1 hit

    Sequencei

    Sequence statusi: Complete.

    O43825-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MLQWRRRHCC FAKMTWNAKR SLFRTHLIGV LSLVFLFAMF LFFNHHDWLP
    60 70 80 90 100
    GRAGFKENPV TYTFRGFRST KSETNHSSLR NIWKETVPQT LRPQTATNSN
    110 120 130 140 150
    NTDLSPQGVT GLENTLSANG SIYNEKGTGH PNSYHFKYII NEPEKCQEKS
    160 170 180 190 200
    PFLILLIAAE PGQIEARRAI RQTWGNESLA PGIQITRIFL LGLSIKLNGY
    210 220 230 240 250
    LQRAILEESR QYHDIIQQEY LDTYYNLTIK TLMGMNWVAT YCPHIPYVMK
    260 270 280 290 300
    TDSDMFVNTE YLINKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP
    310 320 330 340 350
    DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLGIRRLHLE DVYVGICLAK
    360 370 380 390 400
    LRIDPVPPPN EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN
    410 420
    KHNACANAAK EKAGRYRHRK LH
    Length:422
    Mass (Da):49,213
    Last modified:June 1, 1998 - v1
    Checksum:iBA62942D6AFB4B0C
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti172Q → R in AAG60610 (PubMed:11318611).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Y15014 mRNA Translation: CAA75245.1
    Y15060 mRNA Translation: CAA75344.1
    AF288390 mRNA Translation: AAG60610.1
    AK314116 mRNA Translation: BAG36808.1
    AL390863 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW91251.1
    BC022507 mRNA Translation: AAH22507.1
    CCDSiCCDS1383.1
    RefSeqiNP_003774.1, NM_003783.3
    UniGeneiHs.518834

    Genome annotation databases

    EnsembliENST00000367434; ENSP00000356404; ENSG00000162630
    GeneIDi8707
    KEGGihsa:8707
    UCSCiuc001gtc.5 human

    Similar proteinsi

    Entry informationi

    Entry nameiB3GT2_HUMAN
    AccessioniPrimary (citable) accession number: O43825
    Secondary accession number(s): B2RAB1, Q9BZQ9
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: June 1, 1998
    Last modified: June 20, 2018
    This is version 125 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

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