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Protein

Putative GTP-binding protein 6

Gene

GTPBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Cofactori

Mg2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi308MagnesiumPROSITE-ProRule annotation1
Metal bindingi329MagnesiumPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi301 – 308GTPPROSITE-ProRule annotation8
Nucleotide bindingi327 – 331GTPPROSITE-ProRule annotation5
Nucleotide bindingi349 – 352GTPPROSITE-ProRule annotation4
Nucleotide bindingi418 – 421GTPPROSITE-ProRule annotation4
Nucleotide bindingi437 – 439GTPPROSITE-ProRule annotation3

GO - Molecular functioni

  • GTP binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • ribosome binding Source: GO_Central

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative GTP-binding protein 6
Alternative name(s):
Pseudoautosomal GTP-binding protein-like
Gene namesi
Name:GTPBP6
Synonyms:PGPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000178605.13
HGNCiHGNC:30189 GTPBP6
MIMi300124 gene
neXtProtiNX_O43824

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178605

Polymorphism and mutation databases

BioMutaiGTPBP6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047981 – 516Putative GTP-binding protein 6Add BLAST516

Proteomic databases

EPDiO43824
PaxDbiO43824
PeptideAtlasiO43824
PRIDEiO43824
ProteomicsDBi49190

PTM databases

iPTMnetiO43824
PhosphoSitePlusiO43824

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000178605 Expressed in 203 organ(s), highest expression level in right ovary
CleanExiHS_GTPBP6

Organism-specific databases

HPAiHPA035467
HPA055418

Interactioni

Protein-protein interaction databases

BioGridi113858, 18 interactors
IntActiO43824, 2 interactors
STRINGi9606.ENSP00000316598

Structurei

3D structure databases

ProteinModelPortaliO43824
SMRiO43824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 459Hflx-type GPROSITE-ProRule annotationAdd BLAST165

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0410 Eukaryota
COG2262 LUCA
GeneTreeiENSGT00390000001397
HOGENOMiHOG000260368
HOVERGENiHBG052970
InParanoidiO43824
OMAiMDTVGFM
PhylomeDBiO43824
TreeFamiTF315022

Family and domain databases

CDDicd01878 HflX, 1 hit
InterProiView protein in InterPro
IPR030394 G_HFLX_dom
IPR032305 GTP-bd_M
IPR006073 GTP_binding_domain
IPR016496 GTPase_HflX
IPR025121 GTPase_HflX_N
IPR027417 P-loop_NTPase
PANTHERiPTHR10229 PTHR10229, 1 hit
PfamiView protein in Pfam
PF16360 GTP-bdg_M, 1 hit
PF13167 GTP-bdg_N, 1 hit
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF006809 GTP-binding_hflX_prd, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03156 GTP_HflX, 1 hit
PROSITEiView protein in PROSITE
PS51705 G_HFLX, 1 hit

Sequencei

Sequence statusi: Complete.

O43824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP
60 70 80 90 100
WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL
110 120 130 140 150
VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK
160 170 180 190 200
LIFGKGNFEH LTEKIRGSPD ITCVFLNVER MAAPTKKELE AAWGVEVFDR
210 220 230 240 250
FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM
260 270 280 290 300
GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV
310 320 330 340 350
GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT
360 370 380 390 400
IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL
410 420 430 440 450
RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE
460 470 480 490 500
LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV
510
IISNSAYGKF RKLFPG
Length:516
Mass (Da):56,897
Last modified:March 28, 2018 - v4
Checksum:i0BCF19A88FB5A984
GO

Sequence cautioni

The sequence AAH14636 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD97132 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA74749 differs from that shown. Reason: Frameshift at position 64.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60D → E in CAA74749 (PubMed:9466997).Curated1
Sequence conflicti61G → R in BAD97132 (Ref. 3) Curated1
Sequence conflicti67G → E in CAA74749 (PubMed:9466997).Curated1
Sequence conflicti70E → K in CAA74749 (PubMed:9466997).Curated1
Sequence conflicti171I → V in AAH14636 (PubMed:15489334).Curated1
Sequence conflicti171I → V in AAP36024 (Ref. 5) Curated1
Sequence conflicti171I → V in CAA74749 (PubMed:9466997).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126759 Genomic DNA No translation available.
BX000483 Genomic DNA No translation available.
FO681518 Genomic DNA No translation available.
Y14391 mRNA Translation: CAA74749.2 Frameshift.
AK223412 mRNA Translation: BAD97132.1 Different initiation.
BC014636 mRNA Translation: AAH14636.1 Different initiation.
BT007360 mRNA Translation: AAP36024.1
CCDSiCCDS75943.1
RefSeqiNP_036359.3, NM_012227.3
UniGeneiHs.437145

Genome annotation databases

EnsembliENST00000326153; ENSP00000316598; ENSG00000178605
GeneIDi8225
KEGGihsa:8225

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126759 Genomic DNA No translation available.
BX000483 Genomic DNA No translation available.
FO681518 Genomic DNA No translation available.
Y14391 mRNA Translation: CAA74749.2 Frameshift.
AK223412 mRNA Translation: BAD97132.1 Different initiation.
BC014636 mRNA Translation: AAH14636.1 Different initiation.
BT007360 mRNA Translation: AAP36024.1
CCDSiCCDS75943.1
RefSeqiNP_036359.3, NM_012227.3
UniGeneiHs.437145

3D structure databases

ProteinModelPortaliO43824
SMRiO43824
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113858, 18 interactors
IntActiO43824, 2 interactors
STRINGi9606.ENSP00000316598

PTM databases

iPTMnetiO43824
PhosphoSitePlusiO43824

Polymorphism and mutation databases

BioMutaiGTPBP6

Proteomic databases

EPDiO43824
PaxDbiO43824
PeptideAtlasiO43824
PRIDEiO43824
ProteomicsDBi49190

Protocols and materials databases

DNASUi8225
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326153; ENSP00000316598; ENSG00000178605
GeneIDi8225
KEGGihsa:8225

Organism-specific databases

CTDi8225
EuPathDBiHostDB:ENSG00000178605.13
GeneCardsiGTPBP6
HGNCiHGNC:30189 GTPBP6
HPAiHPA035467
HPA055418
MIMi300124 gene
neXtProtiNX_O43824
OpenTargetsiENSG00000178605
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0410 Eukaryota
COG2262 LUCA
GeneTreeiENSGT00390000001397
HOGENOMiHOG000260368
HOVERGENiHBG052970
InParanoidiO43824
OMAiMDTVGFM
PhylomeDBiO43824
TreeFamiTF315022

Miscellaneous databases

ChiTaRSiGTPBP6 human
GeneWikiiGTPBP6
GenomeRNAii8225
PROiPR:O43824
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178605 Expressed in 203 organ(s), highest expression level in right ovary
CleanExiHS_GTPBP6

Family and domain databases

CDDicd01878 HflX, 1 hit
InterProiView protein in InterPro
IPR030394 G_HFLX_dom
IPR032305 GTP-bd_M
IPR006073 GTP_binding_domain
IPR016496 GTPase_HflX
IPR025121 GTPase_HflX_N
IPR027417 P-loop_NTPase
PANTHERiPTHR10229 PTHR10229, 1 hit
PfamiView protein in Pfam
PF16360 GTP-bdg_M, 1 hit
PF13167 GTP-bdg_N, 1 hit
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF006809 GTP-binding_hflX_prd, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03156 GTP_HflX, 1 hit
PROSITEiView protein in PROSITE
PS51705 G_HFLX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB6_HUMAN
AccessioniPrimary (citable) accession number: O43824
Secondary accession number(s): H0Y2S1, Q53F77, Q5HYX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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