UniProtKB - O43824 (GTPB6_HUMAN)
Protein
Putative GTP-binding protein 6
Gene
GTPBP6
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Cofactori
Mg2+PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 308 | MagnesiumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 329 | MagnesiumPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 301 – 308 | GTPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 327 – 331 | GTPPROSITE-ProRule annotation | 5 | |
Nucleotide bindingi | 349 – 352 | GTPPROSITE-ProRule annotation | 4 | |
Nucleotide bindingi | 418 – 421 | GTPPROSITE-ProRule annotation | 4 | |
Nucleotide bindingi | 437 – 439 | GTPPROSITE-ProRule annotation | 3 |
GO - Molecular functioni
- GTP binding Source: ProtInc
- metal ion binding Source: UniProtKB-KW
- ribosome binding Source: GO_Central
Keywordsi
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O43824 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative GTP-binding protein 6Alternative name(s): Pseudoautosomal GTP-binding protein-like |
Gene namesi | Name:GTPBP6 Synonyms:PGPL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30189, GTPBP6 |
MIMi | 300124, gene |
neXtProti | NX_O43824 |
VEuPathDBi | HostDB:ENSG00000178605.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8225 |
OpenTargetsi | ENSG00000178605 |
Miscellaneous databases
Pharosi | O43824, Tdark |
Genetic variation databases
BioMutai | GTPBP6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304798 | 1 – 516 | Putative GTP-binding protein 6Add BLAST | 516 |
Proteomic databases
EPDi | O43824 |
jPOSTi | O43824 |
MassIVEi | O43824 |
PaxDbi | O43824 |
PeptideAtlasi | O43824 |
PRIDEi | O43824 |
ProteomicsDBi | 34343 49190 |
PTM databases
iPTMneti | O43824 |
PhosphoSitePlusi | O43824 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000178605, Expressed in right ovary and 216 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113858, 44 interactors |
IntActi | O43824, 7 interactors |
STRINGi | 9606.ENSP00000316598 |
Miscellaneous databases
RNActi | O43824, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 295 – 459 | Hflx-type GPROSITE-ProRule annotationAdd BLAST | 165 |
Sequence similaritiesi
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0410, Eukaryota |
GeneTreei | ENSGT00390000001397 |
InParanoidi | O43824 |
OMAi | MDTVGFM |
OrthoDBi | 1121388at2759 |
PhylomeDBi | O43824 |
TreeFami | TF315022 |
Family and domain databases
CDDi | cd01878, HflX, 1 hit |
Gene3Di | 3.40.50.11060, 1 hit |
InterProi | View protein in InterPro IPR030394, G_HFLX_dom IPR006073, GTP-bd IPR032305, GTP-bd_M IPR016496, GTPase_HflX IPR025121, GTPase_HflX_N IPR042108, GTPase_HflX_N_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR10229, PTHR10229, 1 hit |
Pfami | View protein in Pfam PF16360, GTP-bdg_M, 1 hit PF13167, GTP-bdg_N, 1 hit PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03156, GTP_HflX, 1 hit |
PROSITEi | View protein in PROSITE PS51705, G_HFLX, 1 hit |
i Sequence
Sequence statusi: Complete.
O43824-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP
60 70 80 90 100
WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL
110 120 130 140 150
VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK
160 170 180 190 200
LIFGKGNFEH LTEKIRGSPD ITCVFLNVER MAAPTKKELE AAWGVEVFDR
210 220 230 240 250
FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM
260 270 280 290 300
GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV
310 320 330 340 350
GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT
360 370 380 390 400
IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL
410 420 430 440 450
RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE
460 470 480 490 500
LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV
510
IISNSAYGKF RKLFPG
Sequence cautioni
The sequence AAH14636 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD97132 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA74749 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | D → E in CAA74749 (PubMed:9466997).Curated | 1 | |
Sequence conflicti | 61 | G → R in BAD97132 (Ref. 3) Curated | 1 | |
Sequence conflicti | 67 | G → E in CAA74749 (PubMed:9466997).Curated | 1 | |
Sequence conflicti | 70 | E → K in CAA74749 (PubMed:9466997).Curated | 1 | |
Sequence conflicti | 171 | I → V in AAH14636 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 171 | I → V in AAP36024 (Ref. 5) Curated | 1 | |
Sequence conflicti | 171 | I → V in CAA74749 (PubMed:9466997).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC126759 Genomic DNA No translation available. BX000483 Genomic DNA No translation available. FO681518 Genomic DNA No translation available. Y14391 mRNA Translation: CAA74749.2 Frameshift. AK223412 mRNA Translation: BAD97132.1 Different initiation. BC014636 mRNA Translation: AAH14636.1 Different initiation. BT007360 mRNA Translation: AAP36024.1 |
CCDSi | CCDS75943.1 |
RefSeqi | NP_036359.3, NM_012227.3 |
Genome annotation databases
Ensembli | ENST00000326153; ENSP00000316598; ENSG00000178605 |
GeneIDi | 8225 |
KEGGi | hsa:8225 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC126759 Genomic DNA No translation available. BX000483 Genomic DNA No translation available. FO681518 Genomic DNA No translation available. Y14391 mRNA Translation: CAA74749.2 Frameshift. AK223412 mRNA Translation: BAD97132.1 Different initiation. BC014636 mRNA Translation: AAH14636.1 Different initiation. BT007360 mRNA Translation: AAP36024.1 |
CCDSi | CCDS75943.1 |
RefSeqi | NP_036359.3, NM_012227.3 |
3D structure databases
SMRi | O43824 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113858, 44 interactors |
IntActi | O43824, 7 interactors |
STRINGi | 9606.ENSP00000316598 |
PTM databases
iPTMneti | O43824 |
PhosphoSitePlusi | O43824 |
Genetic variation databases
BioMutai | GTPBP6 |
Proteomic databases
EPDi | O43824 |
jPOSTi | O43824 |
MassIVEi | O43824 |
PaxDbi | O43824 |
PeptideAtlasi | O43824 |
PRIDEi | O43824 |
ProteomicsDBi | 34343 49190 |
Protocols and materials databases
Antibodypediai | 23297, 36 antibodies |
DNASUi | 8225 |
Genome annotation databases
Ensembli | ENST00000326153; ENSP00000316598; ENSG00000178605 |
GeneIDi | 8225 |
KEGGi | hsa:8225 |
Organism-specific databases
CTDi | 8225 |
DisGeNETi | 8225 |
GeneCardsi | GTPBP6 |
HGNCi | HGNC:30189, GTPBP6 |
MIMi | 300124, gene |
neXtProti | NX_O43824 |
OpenTargetsi | ENSG00000178605 |
VEuPathDBi | HostDB:ENSG00000178605.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0410, Eukaryota |
GeneTreei | ENSGT00390000001397 |
InParanoidi | O43824 |
OMAi | MDTVGFM |
OrthoDBi | 1121388at2759 |
PhylomeDBi | O43824 |
TreeFami | TF315022 |
Enzyme and pathway databases
PathwayCommonsi | O43824 |
Miscellaneous databases
BioGRID-ORCSi | 8225, 25 hits in 118 CRISPR screens |
ChiTaRSi | GTPBP6, human |
GeneWikii | GTPBP6 |
GenomeRNAii | 8225 |
Pharosi | O43824, Tdark |
PROi | PR:O43824 |
RNActi | O43824, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178605, Expressed in right ovary and 216 other tissues |
Family and domain databases
CDDi | cd01878, HflX, 1 hit |
Gene3Di | 3.40.50.11060, 1 hit |
InterProi | View protein in InterPro IPR030394, G_HFLX_dom IPR006073, GTP-bd IPR032305, GTP-bd_M IPR016496, GTPase_HflX IPR025121, GTPase_HflX_N IPR042108, GTPase_HflX_N_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR10229, PTHR10229, 1 hit |
Pfami | View protein in Pfam PF16360, GTP-bdg_M, 1 hit PF13167, GTP-bdg_N, 1 hit PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03156, GTP_HflX, 1 hit |
PROSITEi | View protein in PROSITE PS51705, G_HFLX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GTPB6_HUMAN | |
Accessioni | O43824Primary (citable) accession number: O43824 Secondary accession number(s): H0Y2S1, Q53F77, Q5HYX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | March 28, 2018 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families