Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O43824 (GTPB6_HUMAN)

Entry version 145 (08 May 2019)
Sequence version 4 (28 Mar 2018)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Putative GTP-binding protein 6

Gene

GTPBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi308MagnesiumPROSITE-ProRule annotation1
Metal bindingi329MagnesiumPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi301 – 308GTPPROSITE-ProRule annotation8
Nucleotide bindingi327 – 331GTPPROSITE-ProRule annotation5
Nucleotide bindingi349 – 352GTPPROSITE-ProRule annotation4
Nucleotide bindingi418 – 421GTPPROSITE-ProRule annotation4
Nucleotide bindingi437 – 439GTPPROSITE-ProRule annotation3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTP binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • ribosome binding Source: GO_Central
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative GTP-binding protein 6
Alternative name(s):
Pseudoautosomal GTP-binding protein-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTPBP6
Synonyms:PGPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30189 GTPBP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300124 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43824

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000178605

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GTPBP6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003047981 – 516Putative GTP-binding protein 6Add BLAST516

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43824

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43824

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43824

PeptideAtlas

More...PeptideAtlasi		O43824

PRoteomics IDEntifications database

More...PRIDEi		O43824

ProteomicsDB human proteome resource

More...ProteomicsDBi		49190

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43824

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43824

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178605 Expressed in 203 organ(s), highest expression level in right ovary

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035467
HPA055418

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113858, 20 interactors

Protein interaction database and analysis system

More...IntActi		O43824, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000316598

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43824

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini295 – 459Hflx-type GPROSITE-ProRule annotationAdd BLAST165

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0410 Eukaryota
COG2262 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001397

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000260368

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43824

Identification of Orthologs from Complete Genome Data

More...OMAi		MDTVGFM

Database of Orthologous Groups

More...OrthoDBi		1121388at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43824

TreeFam database of animal gene trees

More...TreeFami		TF315022

Family and domain databases

Conserved Domains Database

More...CDDi		cd01878 HflX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11060, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030394 G_HFLX_dom
IPR032305 GTP-bd_M
IPR006073 GTP_binding_domain
IPR016496 GTPase_HflX
IPR025121 GTPase_HflX_N
IPR042108 GTPase_HflX_N_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR10229 PTHR10229, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16360 GTP-bdg_M, 1 hit
PF13167 GTP-bdg_N, 1 hit
PF01926 MMR_HSR1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006809 GTP-binding_hflX_prd, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03156 GTP_HflX, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51705 G_HFLX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP 
        60         70         80         90        100
WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL 
       110        120        130        140        150
VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK 
       160        170        180        190        200
LIFGKGNFEH LTEKIRGSPD ITCVFLNVER MAAPTKKELE AAWGVEVFDR 
       210        220        230        240        250
FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM 
       260        270        280        290        300
GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV 
       310        320        330        340        350
GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT 
       360        370        380        390        400
IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL 
       410        420        430        440        450
RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE 
       460        470        480        490        500
LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV 
       510 
IISNSAYGKF RKLFPG
Length:516
Mass (Da):56,897
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BCF19A88FB5A984
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14636 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD97132 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA74749 differs from that shown. Reason: Frameshift at position 64.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60D → E in CAA74749 (PubMed:9466997).Curated1
Sequence conflicti61G → R in BAD97132 (Ref. 3) Curated1
Sequence conflicti67G → E in CAA74749 (PubMed:9466997).Curated1
Sequence conflicti70E → K in CAA74749 (PubMed:9466997).Curated1
Sequence conflicti171I → V in AAH14636 (PubMed:15489334).Curated1
Sequence conflicti171I → V in AAP36024 (Ref. 5) Curated1
Sequence conflicti171I → V in CAA74749 (PubMed:9466997).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC126759 Genomic DNA No translation available.
BX000483 Genomic DNA No translation available.
FO681518 Genomic DNA No translation available.
Y14391 mRNA Translation: CAA74749.2 Frameshift.
AK223412 mRNA Translation: BAD97132.1 Different initiation.
BC014636 mRNA Translation: AAH14636.1 Different initiation.
BT007360 mRNA Translation: AAP36024.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS75943.1

NCBI Reference Sequences

More...RefSeqi		NP_036359.3, NM_012227.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326153; ENSP00000316598; ENSG00000178605

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8225

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126759 Genomic DNA No translation available.
BX000483 Genomic DNA No translation available.
FO681518 Genomic DNA No translation available.
Y14391 mRNA Translation: CAA74749.2 Frameshift.
AK223412 mRNA Translation: BAD97132.1 Different initiation.
BC014636 mRNA Translation: AAH14636.1 Different initiation.
BT007360 mRNA Translation: AAP36024.1
CCDSiCCDS75943.1
RefSeqiNP_036359.3, NM_012227.3

3D structure databases

SMRiO43824
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113858, 20 interactors
IntActiO43824, 3 interactors
STRINGi9606.ENSP00000316598

PTM databases

iPTMnetiO43824
PhosphoSitePlusiO43824

Polymorphism and mutation databases

BioMutaiGTPBP6

Proteomic databases

EPDiO43824
jPOSTiO43824
PaxDbiO43824
PeptideAtlasiO43824
PRIDEiO43824
ProteomicsDBi49190

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8225
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326153; ENSP00000316598; ENSG00000178605
GeneIDi8225
KEGGihsa:8225

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8225

GeneCards: human genes, protein and diseases

More...GeneCardsi		GTPBP6
HGNCiHGNC:30189 GTPBP6
HPAiHPA035467
HPA055418
MIMi300124 gene
neXtProtiNX_O43824
OpenTargetsiENSG00000178605

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0410 Eukaryota
COG2262 LUCA
GeneTreeiENSGT00390000001397
HOGENOMiHOG000260368
InParanoidiO43824
OMAiMDTVGFM
OrthoDBi1121388at2759
PhylomeDBiO43824
TreeFamiTF315022

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GTPBP6 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GTPBP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8225

Protein Ontology

More...PROi		PR:O43824

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000178605 Expressed in 203 organ(s), highest expression level in right ovary

Family and domain databases

CDDicd01878 HflX, 1 hit
Gene3Di3.40.50.11060, 1 hit
InterProiView protein in InterPro
IPR030394 G_HFLX_dom
IPR032305 GTP-bd_M
IPR006073 GTP_binding_domain
IPR016496 GTPase_HflX
IPR025121 GTPase_HflX_N
IPR042108 GTPase_HflX_N_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR10229 PTHR10229, 1 hit
PfamiView protein in Pfam
PF16360 GTP-bdg_M, 1 hit
PF13167 GTP-bdg_N, 1 hit
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF006809 GTP-binding_hflX_prd, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03156 GTP_HflX, 1 hit
PROSITEiView protein in PROSITE
PS51705 G_HFLX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTPB6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43824
Secondary accession number(s): H0Y2S1, Q53F77, Q5HYX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 28, 2018
Last modified: May 8, 2019
This is version 145 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again