GTPBP6

Functionⁱ

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Cofactorⁱ

Mg²⁺PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	308	MagnesiumPROSITE-ProRule annotation		1
Metal bindingⁱ	329	MagnesiumPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	301 – 308	GTPPROSITE-ProRule annotation	8
Nucleotide bindingⁱ	327 – 331	GTPPROSITE-ProRule annotation	5
Nucleotide bindingⁱ	349 – 352	GTPPROSITE-ProRule annotation	4
Nucleotide bindingⁱ	418 – 421	GTPPROSITE-ProRule annotation	4
Nucleotide bindingⁱ	437 – 439	GTPPROSITE-ProRule annotation	3

GO - Molecular functionⁱ

GTP binding
Source: ProtInc
Traceable author statementⁱ
- 9466997
metal ion binding Source: UniProtKB-KW
ribosome binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Ligand

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative GTP-binding protein 6 Alternative name(s): Pseudoautosomal GTP-binding protein-like
Gene namesⁱ	Name:GTPBP6 Synonyms:PGPL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178605.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30189 GTPBP6
MIMⁱ	300124 gene
neXtProtⁱ	NX_O43824

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000178605

OpenTargetsⁱ

ENSG00000178605

Polymorphism and mutation databases

BioMutaⁱ	GTPBP6

BioMutaⁱ

GTPBP6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000304798	1 – 516	Putative GTP-binding protein 6Add BLAST		516

Proteomic databases

EPDⁱ	O43824
PaxDbⁱ	O43824
PeptideAtlas More...PeptideAtlasⁱ	O43824
PRIDEⁱ	O43824
ProteomicsDBⁱ	49190

PTM databases

iPTMnetⁱ	O43824
PhosphoSitePlusⁱ	O43824

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000178605 Expressed in 203 organ(s), highest expression level in right ovary
CleanExⁱ	HS_GTPBP6

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035467 HPA055418

HPAⁱ

HPA035467
HPA055418

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	113858, 18 interactors
IntActⁱ	O43824, 2 interactors
STRINGⁱ	9606.ENSP00000316598

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43824
SMRⁱ	O43824
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	295 – 459	Hflx-type GPROSITE-ProRule annotationAdd BLAST		165

Sequence similaritiesⁱ

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0410 Eukaryota COG2262 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001397
HOGENOMⁱ	HOG000260368
HOVERGENⁱ	HBG052970
InParanoidⁱ	O43824
OMAⁱ	MDTVGFM
PhylomeDBⁱ	O43824
TreeFamⁱ	TF315022

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01878 HflX, 1 hit
InterProⁱ	View protein in InterPro IPR030394 G_HFLX_dom IPR032305 GTP-bd_M IPR006073 GTP_binding_domain IPR016496 GTPase_HflX IPR025121 GTPase_HflX_N IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10229 PTHR10229, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16360 GTP-bdg_M, 1 hit PF13167 GTP-bdg_N, 1 hit PF01926 MMR_HSR1, 1 hit
PIRSFⁱ	PIRSF006809 GTP-binding_hflX_prd, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR03156 GTP_HflX, 1 hit
PROSITEⁱ	View protein in PROSITE PS51705 G_HFLX, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O43824-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP 
        60         70         80         90        100
WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL 
       110        120        130        140        150
VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK 
       160        170        180        190        200
LIFGKGNFEH LTEKIRGSPD ITCVFLNVER MAAPTKKELE AAWGVEVFDR 
       210        220        230        240        250
FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM 
       260        270        280        290        300
GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV 
       310        320        330        340        350
GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT 
       360        370        380        390        400
IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL 
       410        420        430        440        450
RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE 
       460        470        480        490        500
LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV 
       510 
IISNSAYGKF RKLFPG

Length:516

Mass (Da):56,897

Last modified:March 28, 2018 - v4

Checksum:ⁱ0BCF19A88FB5A984

GO

Sequence cautionⁱ

The sequence AAH14636 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD97132 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA74749 differs from that shown. Reason: Frameshift at position 64.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	60	D → E in CAA74749 (PubMed:9466997).Curated	1
Sequence conflictⁱ	61	G → R in BAD97132 (Ref. 3) Curated	1
Sequence conflictⁱ	67	G → E in CAA74749 (PubMed:9466997).Curated	1
Sequence conflictⁱ	70	E → K in CAA74749 (PubMed:9466997).Curated	1
Sequence conflictⁱ	171	I → V in AAH14636 (PubMed:15489334).Curated	1
Sequence conflictⁱ	171	I → V in AAP36024 (Ref. 5) Curated	1
Sequence conflictⁱ	171	I → V in CAA74749 (PubMed:9466997).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC126759 Genomic DNA No translation available. BX000483 Genomic DNA No translation available. FO681518 Genomic DNA No translation available. Y14391 mRNA Translation: CAA74749.2 Frameshift. AK223412 mRNA Translation: BAD97132.1 Different initiation. BC014636 mRNA Translation: AAH14636.1 Different initiation. BT007360 mRNA Translation: AAP36024.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS75943.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036359.3, NM_012227.3
UniGeneⁱ	Hs.437145

Genome annotation databases

Ensemblⁱ	ENST00000326153; ENSP00000316598; ENSG00000178605
GeneIDⁱ	8225
KEGGⁱ	hsa:8225

Protein	Similar proteins		Species	Score	Length	Source
O43824	cDNA FLJ90047 fis, clone HEMBA1002316, highly similar to GTP-binding protein 6		HUMAN		174	UniRef100_O43824
Uncharacterized protein		GORGO		286
UPI0005D01607		HUMAN		336
UPI0003EB0528		HUMAN		377

Protein	Similar proteins		Species	Score	Length	Source
O43824	cDNA FLJ90047 fis, clone HEMBA1002316, highly similar to GTP-binding protein 6		HUMAN		174	UniRef90_O43824
Uncharacterized protein		GORGO		286
Uncharacterized protein		RHIBE		516
Uncharacterized protein		CERAT		516
Uncharacterized protein		MACFA		516
+11

Protein	Similar proteins		Species	Score	Length	Source
O43824	cDNA FLJ90047 fis, clone HEMBA1002316, highly similar to GTP-binding protein 6		HUMAN		174	UniRef50_O43824
Uncharacterized protein		GORGO		286
Uncharacterized protein		CERAT		516
Uncharacterized protein		RHIBE		516
Uncharacterized protein		MACFA		516
+44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC126759 Genomic DNA No translation available. BX000483 Genomic DNA No translation available. FO681518 Genomic DNA No translation available. Y14391 mRNA Translation: CAA74749.2 Frameshift. AK223412 mRNA Translation: BAD97132.1 Different initiation. BC014636 mRNA Translation: AAH14636.1 Different initiation. BT007360 mRNA Translation: AAP36024.1
CCDSⁱ	CCDS75943.1
RefSeqⁱ	NP_036359.3, NM_012227.3
UniGeneⁱ	Hs.437145

3D structure databases

ProteinModelPortalⁱ	O43824
SMRⁱ	O43824
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113858, 18 interactors
IntActⁱ	O43824, 2 interactors
STRINGⁱ	9606.ENSP00000316598

PTM databases

iPTMnetⁱ	O43824
PhosphoSitePlusⁱ	O43824

Polymorphism and mutation databases

BioMutaⁱ	GTPBP6

BioMutaⁱ

GTPBP6

Proteomic databases

EPDⁱ	O43824
PaxDbⁱ	O43824
PeptideAtlasⁱ	O43824
PRIDEⁱ	O43824
ProteomicsDBⁱ	49190

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8225
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326153; ENSP00000316598; ENSG00000178605
GeneIDⁱ	8225
KEGGⁱ	hsa:8225

Organism-specific databases

CTDⁱ	8225
EuPathDBⁱ	HostDB:ENSG00000178605.13
GeneCardsⁱ	GTPBP6
HGNCⁱ	HGNC:30189 GTPBP6
HPAⁱ	HPA035467 HPA055418
MIMⁱ	300124 gene
neXtProtⁱ	NX_O43824
OpenTargetsⁱ	ENSG00000178605
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0410 Eukaryota COG2262 LUCA
GeneTreeⁱ	ENSGT00390000001397
HOGENOMⁱ	HOG000260368
HOVERGENⁱ	HBG052970
InParanoidⁱ	O43824
OMAⁱ	MDTVGFM
PhylomeDBⁱ	O43824
TreeFamⁱ	TF315022

Miscellaneous databases

ChiTaRSⁱ	GTPBP6 human
GeneWikiⁱ	GTPBP6
GenomeRNAiⁱ	8225
Protein Ontology More...PROⁱ	PR:O43824
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000178605 Expressed in 203 organ(s), highest expression level in right ovary
CleanExⁱ	HS_GTPBP6

Family and domain databases

CDDⁱ	cd01878 HflX, 1 hit
InterProⁱ	View protein in InterPro IPR030394 G_HFLX_dom IPR032305 GTP-bd_M IPR006073 GTP_binding_domain IPR016496 GTPase_HflX IPR025121 GTPase_HflX_N IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10229 PTHR10229, 1 hit
Pfamⁱ	View protein in Pfam PF16360 GTP-bdg_M, 1 hit PF13167 GTP-bdg_N, 1 hit PF01926 MMR_HSR1, 1 hit
PIRSFⁱ	PIRSF006809 GTP-binding_hflX_prd, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR03156 GTP_HflX, 1 hit
PROSITEⁱ	View protein in PROSITE PS51705 G_HFLX, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GTPB6_HUMAN
Accessionⁱ	O43824Primary (citable) accession number: O43824 Secondary accession number(s): H0Y2S1, Q53F77, Q5HYX8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	March 28, 2018
	Last modified:	October 10, 2018
	This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43824 (GTPB6_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Putative GTP-binding protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ